rTMS-induced Cumulative Pattern of sBDNF in Chronic Schizophrenia

February 15, 2015 updated by: HWANG TAEYOUNG, Jeonbuk Provincial Maeumsarang Hospital

Short-Term Response of Serum Brain-Derived Neurotrophic Factor to Repetitive Transcranial Magnetic Stimulation in Patients With Chronic Schizophrenia

This study aims at investigating the neuroplastic potential and the possible factors affecting rehabilitation in chronic schizophrenia patients on stable medication, by investigating the cumulative pattern of serum BDNF representing the neuroplasticity in the brain, through quantitative stimulus such as rTMS.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

Subjects who have been enrolled for this study will take baseline evaluation for sociodemographic data and serum level of BDNF, plasma Prolaction, and magnesium, etc. And then, weekday regular stimulation through rTMS will be applied on DLPFC of brain. After the completion of stimulation for 2 weeks, the change or response of serum BDNF will be analyzed and compared.

Study Type

Interventional

Enrollment (Actual)

21

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Korea, Republic of
    • Jeonbuk
      • Wanju, Jeonbuk, Korea, Republic of, 565844
        • Jeonbuk Provincial Maeumsarang Hospital

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

25 years to 60 years (ADULT)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • duration of illness over 10 years
  • on stable medication, antipsychotics
  • no change on medication within at least 2 weeks
  • Diagnosis of Schizophrenia according to DSM-IV-TR

Exclusion Criteria:

  • left or both-handedness
  • anticonvulsant use
  • lorazepam equivalent over 3 mg

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: BASIC_SCIENCE
  • Allocation: NA
  • Interventional Model: SINGLE_GROUP
  • Masking: NONE

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
EXPERIMENTAL: repetitive TMS
repetitive TMS is a quantified stimulation method of specifie area of brain, for which CR Technology, TAMAS for repetitive TMS was used.
Device: CR Technology, TAMAS for repetitive TMS
repetitive TMS, lef DLPFC, 20Hz, 100% of MEP, 2weeks

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
change from baseline of serum BDNF concentration
Time Frame: baseline-1 week-2 week-4 week
baseline-1 week-2 week-4 week

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Jeonbuk Provincial Maeumsarang Hospital

Investigators

  • Principal Investigator: TAEYOUNG HWANG, M.D., M.P.H., Jeonbuk Provincial Maeumsarang Hospital

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

August 1, 2011

Primary Completion (ACTUAL)

October 1, 2011

Study Completion (ACTUAL)

November 1, 2011

Study Registration Dates

First Submitted

August 28, 2011

First Submitted That Met QC Criteria

August 30, 2011

First Posted (ESTIMATE)

September 1, 2011

Study Record Updates

Last Update Posted (ESTIMATE)

February 18, 2015

Last Update Submitted That Met QC Criteria

February 15, 2015

Last Verified

February 1, 2015

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • rTMS-sBDNF-SPR-2011

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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