- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01761981
Institutional Registry of Haemorrhagic Hereditary Telangiectasia
The purpose of this study is to create an institutional and population-based registry of Haemorrhagic Hereditary Telangiectasia with a prospective survey based on epidemiological data, risk factors, diagnosis, prognosis, treatment, monitoring and survival.
This study will also describe the occurrence of Haemorrhagic Hereditary Telangiectasia in the population of HIBA in the Central Hospital, as well as the characteristics of clinical presentation and evolution.
Study Overview
Status
Conditions
Detailed Description
Haemorrhagic Hereditary Telangiectasia is a uncommon autosomic hereditary disorder caracterizad for recurrent epistaxis,cutaneomucous telangiectasias and arteriovenous malformations in diferent organs; brain, lung, liver and gastrointestinal are more often afected . Afect one in 5000-8000 individual in worldwide. HHT may produce important morbidity like brain absces, stroke, hemoptisis and cronic ferropenic anemia.
Molecular mechanism of this disorder are complex and still no fully dilucidated. The genes mutated in HHT encode endothelial cell-expressed proteins that mediate signalling by the transforming growth factor (TGF)b superfamily. Endoglin (HHT type I) and ACVRL-1 (HHT type 2) mutations are responsible in more than 80% of the individuals. Mutation of SMAD 4 protein (MADH4)cause HHT in association with juvenile polyposis. HHT may associated with primary pulmonary hypertension en more rare cases.
There arent HHT register in Argentina and Latinamerican population. This registry may gader valious information in order to generate a better diagnosis and treatment of our population and others.
Study Type
Enrollment (Anticipated)
Contacts and Locations
Study Contact
- Name: Marcelo M Serra, MD
- Phone Number: 4419 +541149590200
- Email: marcelo.serra@hospitalitaliano.org.ar
Study Contact Backup
- Name: Diego H Giunta, MD
- Phone Number: 4419 +541149590200
- Email: diego.giunta@hospitalitaliano.org.ar
Study Locations
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-
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Buenos Aires, Argentina, 1081
- Recruiting
- Hospital Italiano de Buenos Aires
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Contact:
- Marcelo M Serra, MD
- Phone Number: 4419 +541149590200
- Email: marcelo.serra@hospitalitaliano.org.ar
-
Contact:
- Diego H Giunta, MD
- Phone Number: 4419 +541149590200
- Email: diego.giunta@hospitalitaliano.org.ar
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-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- ADULT
- OLDER_ADULT
- CHILD
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
- Patients with HHT defined.
- Followed in Unidad HHT of Hospital Italiano de Buenos Aires.
Exclusion Criteria:
1. Denied to participated in the registry or inform consent process.
Study Plan
How is the study designed?
Design Details
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
morbidity
Time Frame: 1 year
|
Control visit every three month
|
1 year
|
Collaborators and Investigators
Investigators
- Principal Investigator: Marcelo M Serra, MD, HHT Center of Excelence Hospital Italiano de Buenos Aires
Publications and helpful links
Study record dates
Study Major Dates
Study Start
Primary Completion (ANTICIPATED)
Study Completion (ANTICIPATED)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (ESTIMATE)
Study Record Updates
Last Update Posted (ESTIMATE)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- 1900
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Haemorrhagic Hereditary Telangiectasia
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University Hospital, EssenCompleted
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Imperial College LondonCompletedHereditary Haemorrhagic Telangiectasia (HHT)United Kingdom
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University Hospital, EssenCompletedHereditary Haemorrhagic Telangiectasia (HHT)Germany
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University Hospital, EssenRecruitingHereditary Haemorrhagic TelangiectasiaGermany
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Hospices Civils de LyonCompleted
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Imperial College LondonCompletedHereditary Haemorrhagic TelangiectasiaUnited Kingdom
-
Hospices Civils de LyonCompletedLiver Transplant | Hereditary Haemorrhagic Telangiectasia
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GlaxoSmithKlineTerminatedTelangiectasia, Hereditary HemorrhagicUnited States, Canada
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St. Paul's Hospital, CanadaUnknown
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Hospices Civils de LyonCompletedPulmonary Arteriovenous Malformations (PAVMs) in Hereditary Haemorrhagic Telangiectasia (HHT) (PAVM)Pulmonary Arteriovenous Malformation | Hereditary Haemorrhagic Telangiectasia | Cerebral Disorder