Effects of the Sugar Sucrose on Bodyweight and Energy Intake Over 28 Days in Obese Women

This study partially replicates two previous studies with normal weight women, and overweight women. Both found that women could compensate for sucrose added to the diet in carbonated soft drinks (4 x250ml total1800 kJ per day) when it was given blind over a period of 4 weeks. The hypothesis is that this applies also to obese women, who will not gain weight, increase overall energy intake in the diet, or eat differently whilst consuming sucrose. 42 participants shall be randomly assigned to either be given carbonated drinks that contain sucrose, or drinks that are artificially sweetened.

Study Overview

• Status: Completed
• Conditions: Obesity
• Intervention / Treatment: Dietary supplement: Sucrose; Dietary supplement: Aspartame

• Study Type: Interventional
• Enrollment (Actual): 41
• Phase: Not Applicable

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 20 years to 55 years (Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: Female

Description

Inclusion Criteria:

• Female
• BMI 30-35 kg/m²
• at least one period of dietary restriction of 4 weeks or more in the last 24 months

Exclusion Criteria:

• dislike of popular sweet carbonated drinks
• dieting during the last month
• history of diabetes
• having an eating disorder
• depression,
• being a smoker
• pregnant
• lactating,
• wearing a pacemaker
• currently taking medication for mood or thyroid disorders

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Single

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Sucrose; Receives sucrose	Dietary supplement: Sucrose; Sucrose in carbonated soft drinks (4 x250ml total1800 kJ per day); Other Names: Irn Bru
Placebo Comparator: Aspartame; Receives Aspartame sweetened drinks	Dietary supplement: Aspartame; Intensely sweetened soft drink (no energy content); Other Names: Diet Irn Bru

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Change in body weight from baseline	4 weeks

Secondary Outcome Measures

Outcome Measure	Time Frame
Mean daily dietary intake estimated from unweighed food diaries	4 weeks

Other Outcome Measures

Outcome Measure	Measure Description	Time Frame
Rated Mood	Mood was assessed 4 times per day over the study period	4 weeks

Collaborators and Investigators

• Sponsor: University of Hull

Publications and helpful links

General Publications

• Reid M, Hammersley R, Duffy M, Ballantyne C. Effects on obese women of the sugar sucrose added to the diet over 28 d: a quasi-randomised, single-blind, controlled trial. Br J Nutr. 2014 Feb;111(3):563-70. doi: 10.1017/S0007114513002687. Epub 2013 Oct 29.

Study record dates

Study Major Dates

• Study Start: September 1, 2006
• Primary Completion (Actual): October 1, 2008
• Study Completion (Actual): October 1, 2008

Study Registration Dates

• First Submitted: February 22, 2013
• First Submitted That Met QC Criteria: February 22, 2013
• First Posted (Estimate): February 26, 2013

Study Record Updates

• Last Update Posted (Estimate): January 28, 2016
• Last Update Submitted That Met QC Criteria: January 26, 2016
• Last Verified: January 1, 2016

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Body Weight
• Other Study ID Numbers: MRRH003