Effect of Pneumoperitoneum on Cognitive Function and Regional Cerebral Oxygen Saturation

Effect of Pneumoperitoneum on Cognitive Function and Regional Cerebral Oxygen

Sponsors

Lead Sponsor: Gachon University Gil Medical Center

Source Gachon University Gil Medical Center
Brief Summary

The investigators hypothesized that the pneumoperitoneum with reverse Trendelenburg position could alter the rSO2 and early postoperative cognitive function.

Detailed Description

Laparoscopic gastrectomy requires a reverse-Trendelenburg position and prolonged pneumoperitoneum and it could cause significant changes in cerebral homeostasis and lead to cognitive dysfunction. We compared changes in haemodynamic variables, regional cerebral oxygen saturation, and early postoperative cognitive function in patients undergoing laparoscopic gastrectomy in the reverse Trendelenburg position with those patients that underwent conventional open gastrectomy.

Overall Status Completed
Start Date April 2013
Completion Date July 2014
Primary Completion Date July 2014
Study Type Observational [Patient Registry]
Primary Outcome
Measure Time Frame
MMSE 5days after end of surgery
Enrollment 60
Condition
Eligibility

Sampling Method: Probability Sample

Criteria:

Inclusion Criteria:

- ASA class I or II, aged 20 to 70 yrs

Exclusion Criteria:

- Patients with morbid obesity (body mass index > 30 kg/m2) or a history of cerebrovascular or respiratory disease were excluded.

Gender: All

Minimum Age: 20 Years

Maximum Age: 70 Years

Healthy Volunteers: No

Overall Official
Last Name Role Affiliation
Hyun Jeong Kwak, M.D. Study Director Gachon University Gil Medical Center
Location
Facility: Gachon University Gil Medical Center
Location Countries

Korea, Republic of

Verification Date

December 2015

Responsible Party

Type: Principal Investigator

Investigator Affiliation: Gachon University Gil Medical Center

Investigator Full Name: Hyun Jeong Kwak

Investigator Title: Associate professor

Keywords
Has Expanded Access No
Condition Browse
Arm Group

Label: Open gastrectomy

Description: patient who undergoing open gastrectomy

Label: laparoscopic gastrectomy

Description: patient who undergoing laparoscopic gastrectomy

Acronym rSO2pneumo
Study Design Info

Observational Model: Case-Control

Time Perspective: Prospective

Source: ClinicalTrials.gov