Pneumoperitoneum Increases Mean Expiratory Flow Rate: an Observational Study in Healthy-lung Patients

Upon introducing pneumoperitoneum our research team noticed a reduction in expiration time displayed on the screen of the anesthesia machine. Since most respirators do not directly indicate the length of expiratory time and the average expiratory flow rate, we decided to investigate whether pneumoperitoneum really accelerates expiratory flow rate and thus shortens expiratory time.

Study Overview

• Status: Active, not recruiting
• Conditions: Pneumoperitoneum Increases Mean Expiratory Flow Rate
• Intervention / Treatment: Procedure: Abdominal Laparascopy

Detailed Description

Furthermore we also intended to investigate which ventilation parameters these changes can be correlated with, elucidating the factors contributing to the acceleration of expiration..

This study aims to uncover the physiological mechanisms behind alterations in respiratory dynamics during and after pneumoperitoneum, offering valuable insights that may aid in refining ventilation strategies in the context of laparoscopic procedures.

• Study Type: Observational
• Enrollment (Estimated): 67

Contacts and Locations

Study Locations

• Hungary
  • Baranya
    • Pécs, Baranya, Hungary, 7623
      • Department of Anaesthesia and Intensive Care, Medical School, University of Pécs

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: Yes

• Sampling Method: Non-Probability Sample

Study Population

Helthy lung patients, over age 18 years, males and femailes together.

Description

Inclusion Criteria:

• elective laparoscopic abdominal surgery, healthy lung patients, age over 18 years. Obrained, written informed consent to partake in the research.

Exclusion Criteria:

chronic obstructive pulmonary disease, bronchial asthma, silicosis, and those with a history of previous lung surgery, patients under 18 years of age, those who had not provided consent, and pregnant individuals were excluded from the study.

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Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Pneumoperitoneum increases mean expiratory flow rate	Elevated intraabdominal pressure leads to a decrease in respiratory compliance and an increase in peak inspiratory pressure., therefore (consequently), expiration commences with a higher pressure difference.	during surgery
Expiration time would be shortened, resulting in a potentially higher flow rate	We assumed (hypothesized) that the expiration time would be shortened, resulting in a potentially higher flow rate compared to pre-pneumoperitoneum conditions. Additionally, we also conducted calculations to establish correlations between respiratory parameters and the mean increment in expiratory flow rate relative to the baseline.	during surgery

Collaborators and Investigators

• Sponsor: Balázs Sütő

Study record dates

Study Major Dates

• Study Start (Actual): October 1, 2023
• Primary Completion (Estimated): January 31, 2024
• Study Completion (Estimated): January 31, 2024

Study Registration Dates

• First Submitted: January 8, 2024
• First Submitted That Met QC Criteria: January 8, 2024
• First Posted (Actual): January 18, 2024

Study Record Updates

• Last Update Posted (Actual): January 18, 2024
• Last Update Submitted That Met QC Criteria: January 8, 2024
• Last Verified: January 1, 2024

More Information

Terms related to this study

• Keywords: mechanical ventilation; body mass index; chest compliance; pneumoperitoneum; expiratory flow rate, intraabdominal pressure, laparoscopic surgery
• Additional Relevant MeSH Terms: Digestive System Diseases; Peritoneal Diseases; Pneumoperitoneum
• Other Study ID Numbers: 9746 - PTE - 2023

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No