Effect of Different Anesthetic Techniques for Isolated Systolic Hypertensive Patients of Abdominal Surgery on Postoperative Hospital Stay and Morbidity

In General anesthesia, two main ways of pain control are used intra-operatively, one is opioids, the other is epidural. Many colleges prefer using epidural analgesia because it is potent and more effective , and also the benefits of stress block, less depression of breath. however, the epidural technique often causes more drop of blood pressure, especially in dehydrated patients. The investigators designed the trial to see if the benefit weigh out the potential risk of epidural in isolated hypertensive patients.

Study Overview

• Status: Withdrawn
• Conditions: Postoperative Complications
• Intervention / Treatment: Drug: remifentanil(Ultiva); Drug: epidural infusing 2% lidocaine

• Study Type: Observational
• Phase: Not Applicable

Contacts and Locations

Study Locations

• China
  • Beijing Municipality
    • Beijing, Beijing Municipality, China
      • PKU 1st hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 50 years to 70 years (Adult, Older Adult)
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

adults aged 50-70 with isolated systolic hypertension .

Description

Inclusion Criteria:

- adults aged 50-70 with isolated systolic hypertension .

Exclusion Criteria:

• age < 50 yr, ASA grade IV, severe cardiac or pulmonary insufficiency (FEV1 < 1 litre) , malignant hypertension, psychiatric illness (intake of psychiatric medication other than selective serotonin re-uptake inhibitors), diastolic blood pressure more than 110 mmHg. emergency surgery, coagulopathy, significant renal and hepatic dysfunction (creatinine > 50% or liver enzymes > 50% upper limit of normal values)

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort
patients receive either epidural or non epidural depends on doctor responsible; epidural or non epidural
patients receive epidural depends on doctor responsible; patients receive non epidural depends on doctor responsible

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Length of postoperative hospital stay	days	5 weeks
cardiovascular morbidity	case	2 weeks
respiratory morbidity	case	2 weeks
postoperative renal failure	case	2 weeks

Collaborators and Investigators

• Sponsor: Peking University First Hospital
• Investigators: Study Chair: Dongxin Wang, MD, PKU 1st hospital

Study record dates

Study Major Dates

• Study Start (Estimated): July 2, 2013
• Primary Completion (Estimated): December 2, 2015
• Study Completion (Estimated): December 2, 2015

Study Registration Dates

• First Submitted: June 19, 2013
• First Submitted That Met QC Criteria: June 21, 2013
• First Posted (Estimated): June 24, 2013

Study Record Updates

• Last Update Posted (Actual): May 20, 2026
• Last Update Submitted That Met QC Criteria: May 16, 2026
• Last Verified: May 1, 2026

More Information

Terms related to this study

• Keywords: remifentanil; morbidity; isolated systolic hypertension; epidural combined general anesthesia
• Additional Relevant MeSH Terms: Essential Hypertension; Vascular Diseases; Cardiovascular Diseases; Pathologic Processes; Hypertension; Pathological Conditions, Signs and Symptoms; Isolated Systolic Hypertension; Postoperative Complications; Physiological Effects of Drugs; Molecular Mechanisms of Pharmacological Action; Anti-Arrhythmia Agents; Central Nervous System Depressants; Peripheral Nervous System Agents; Analgesics; Sensory System Agents; Anesthetics; Analgesics, Opioid; Narcotics; Membrane Transport Modulators; Anesthetics, Local; Voltage-Gated Sodium Channel Blockers; Sodium Channel Blockers; Remifentanil; Lidocaine
• Other Study ID Numbers: EPIISO-021