Study of the Proteome and Cytokines During Inflammatory Syndromes of Different Etiologies. (Proteome)

The hypotheses of our research are based on the fact that various pathological states, infection, cancer, inflammatory disease, can induce an inflammatory syndrome, through different pathways, even though the clinical presentation can be identical. The identification of biological markers specific to an etiology would therefore allow a faster diagnosis and improve care for patients. We thus took an interest in the three groups of diseases most frequently responsible for an inflammatory syndrome, infections, cancers and auto-immune diseases. To achieve this, various methods will be used.

Study Overview

• Status: Terminated
• Conditions: Inflammatory Disease
• Intervention / Treatment: Other: proteomic analysis

• Study Type: Interventional
• Enrollment (Actual): 97
• Phase: Not Applicable

Contacts and Locations

Study Locations

• France
  • Dijon, France, 21079
    • CHU de Dijon

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 90 years (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

Patients presenting an inflammatory syndrome, defined by elevated C-reactive protein (CRP>50mg/L), whose etiology is related to infection, cancer or an inflammatory disease.

• Patients not on treatment (corticoids, immunosuppressive drugs) during the 7 days preceding inclusion
• Age: 18-90 years
• Patients covered by the National Health Insurance Agency
• signed written informed consent form

Exclusion Criteria:

• - Any patient not meeting the inclusion criteria
• Pregnant patients

Study Plan

How is the study designed?

Design Details

• Allocation: Randomized
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

1

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Other: Patients with inflammatory syndrome	Other: proteomic analysis

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
determination of usual parameters of inflammation	at baseline

Collaborators and Investigators

• Sponsor: Centre Hospitalier Universitaire Dijon

Study record dates

Study Major Dates

• Study Start: March 1, 2010
• Primary Completion (Actual): January 1, 2011
• Study Completion (Actual): February 1, 2012

Study Registration Dates

• First Submitted: July 17, 2013
• First Submitted That Met QC Criteria: July 17, 2013
• First Posted (Estimate): July 19, 2013

Study Record Updates

• Last Update Posted (Estimate): July 19, 2013
• Last Update Submitted That Met QC Criteria: July 17, 2013
• Last Verified: July 1, 2013

More Information

Terms related to this study

• Other Study ID Numbers: Bonnotte PHRC IR 2008