- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01979289
Computerized Cognitive Remediation for Geriatric Depression
February 1, 2017 updated by: Weill Medical College of Cornell University
This research study will examine if a targeted computerized cognitive remediation (CCR) training program is better for treating geriatric depression than general computer activity.
We will also examine whether this intervention is related to improvement in cognitive and depressive symptoms.
Elderly patients with depression, who have, and who have not been treated with antidepressant medication for their illness, will be recruited to participate in either a 30 hour cognitive remediation program or general computer activity designed to be both challenging and interesting.
They will be asked to complete between 1 and 3 hours of remediation per day over 4 weeks.
While undergoing the cognitive remediation participants will be asked questions to assess their symptoms of, as well as the severity of, their depression weekly.
This will inform researchers about whether or not the CCR is helping to improve depressive symptoms.
At the end of the CCR study, participants will be given a battery of cognitive tests design to tell investigators whether or not the CCR improved their thinking in a variety of different ways including improving attention, memory, and organization.
Investigators will also determine whether changes in participants' thinking are related to changes in their mood or other depressive symptoms.
It is hoped that information gained from this study will help investigators to better understand the brain processes associated with depression, recovery from depression, and will help inform the development of future alternative treatments for this illness.
Study Overview
Status
Unknown
Intervention / Treatment
Study Type
Interventional
Enrollment (Anticipated)
60
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Contact
- Name: Maria Coluccio, M.A.
- Phone Number: 914-997-4327
Study Contact Backup
- Name: Institute of Geriatric Psychiatry
- Phone Number: 914-997-4331
Study Locations
-
-
New York
-
White Plains, New York, United States, 10605
- Recruiting
- Weill Cornell Medical College
-
Principal Investigator:
- Sarah Shizuko Morimoto, Psy.D.
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
60 years to 89 years (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
Medicated Depressed Participants' Inclusion Criteria
- Age: 60-89 years
- Diagnosis: Major depression, unipolar (by DSM-IV criteria);
- Severity of depression: MADRS >or =15 following at least 8-weeks of controlled antidepressant treatment.
- No plans to change current antidepressant treatment.
Non-Medicated Depressed Participants' Inclusion Criteria
- Age: 60-89 years
- Diagnosis: Major depression, unipolar (by DSM-IV criteria);
- Severity of depression: MADRS >or =15
- No antidepressant treatment within the current episode. -
Exclusion Criteria:
- Psychotic depression by DSM-IV, i.e., presence of delusions with a score higher than 2 (questionable delusion) rated by the Scale for Assessment of Positive Symptoms (SAPS) [47];
- High suicide risk, i.e. intent or plan to attempt suicide in near future;
- Presence of any Axis I psychiatric disorder (other than unipolar major depression) or substance abuse; Axis II diagnosis of antisocial personality (by SCID-P and DSM-IV);
- History of psychiatric disorders other than unipolar major depression or generalized anxiety disorder (bipolar disorder, hypomania, and dysthymia are exclusion criteria);
- Dementia: Mattis Dementia Rating Scale scores below 130 or diagnosis of dementia by DSM-IV; multiple sclerosis, history of head trauma or history of electroconvulsive therapy;
- Amnestic Mild Cognitive Impairment (a-MCI), or Multiple Domain Mild Cognitive Impairment (md-MCI);
- Acute or severe medical illness, i.e., delirium, metastatic cancer, decompensated cardiac, liver or kidney failure, major surgery, stroke or myocardial infarction during the three months prior to entry; or drugs known to cause depression, e.g., reserpine, alpha-methyl-dopa, steroids, sympathomimetics withdrawal;
- Presence of a neurological brain disease and/or history of electroconvulsive therapy;
- Current involvement in psychotherapy;
- Inability to perform any of the ADLs (MAI: ADL subscale) even with assistance, e.g. walking with a cane is not an exclusion criterion;
- Inability to speak English;
- Aphasia;
- Corrected visual acuity < 20/70; Color blindness -
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Double
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Computer Treatment: Active
Computerized Cognitive Remediation: Targeted to underlying cerebral networks associated with remission.
|
|
Active Comparator: Computer Treatment: Control
Computerized Cognitive Remediation: Non-targeted
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Montgomery-Asberg Depression Rating Scale
Time Frame: 4-6 weeks
|
10 item measure to assess the core symptoms and cognitive features of clinical depression
|
4-6 weeks
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Investigators
- Principal Investigator: Sarah Shizuko Morimoto, Psy.D., Weill Medical College of Cornell University
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
August 1, 2012
Primary Completion (Anticipated)
July 1, 2017
Study Completion (Anticipated)
July 1, 2017
Study Registration Dates
First Submitted
October 25, 2013
First Submitted That Met QC Criteria
November 1, 2013
First Posted (Estimate)
November 8, 2013
Study Record Updates
Last Update Posted (Estimate)
February 3, 2017
Last Update Submitted That Met QC Criteria
February 1, 2017
Last Verified
February 1, 2017
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- K23MH095830 (U.S. NIH Grant/Contract)
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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