- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05283629
nCCR for Chemotherapy Related Cognitive Impairment Randomized Study
Neuroplasticity-Based Cognitive Remediation for Chemotherapy Related Cognitive Impairment Randomized Study
Study Overview
Status
Detailed Description
Successes in breast cancer treatment are resulting in a growing number of cancer survivors. This has broadened the scope of care from treating the disease alone to improving the quality of life of cancer survivors. Chemotherapy-related cognitive impairment (CRCI), often referred to by patients as 'chemobrain,' is a common and highly distressful side effect of chemotherapy often reported by breast cancer survivors. Managing the symptoms of CRCI should be integrated with routine cancer care as these symptoms diminish quality of life, impair work performance, and make it more difficult for patients to follow treatment regimens. CRCI can persist for months to years following cancer treatment. However, there are currently no established treatments for CRCI.
The most commonly reported CRCI symptoms in breast cancer survivors include problems with executive functions. Executive function is a cognitive domain involved in planning, problem-solving, organization, and time management. In order to improve executive dysfunction and quality of life in breast cancer survivors, we propose to use a new brain training program called neuroplasticity-based computerized cognitive remediation (nCCR). The term 'neuroplasticity' refers to the brain's ability to modify, change, and adapt throughout life and in response to experience. Neuroplacticity can be induced through the use of focused brain training that nCCR offers. Past work demonstrates that this neuroscience-guided brain training benefits other patient populations with similar cognitive problems and has shown preliminary success in cancer survivors in a small pilot study. If successful, this treatment could have significant benefits for large numbers of breast cancer survivors.
Study Type
Enrollment (Estimated)
Phase
- Not Applicable
Contacts and Locations
Study Contact
- Name: Nicole T Nguyen, MA
- Phone Number: (615) 327-7030
- Email: nicole.tp.nguyen@vumc.org
Study Contact Backup
- Name: Jennifer N Vega, PhD
- Phone Number: (615) 327-7030
- Email: jennifer.n.vega.1@vumc.org
Study Locations
-
-
Tennessee
-
Nashville, Tennessee, United States, 37212
- Recruiting
- Center for Cognitive Medicine at Vanderbilt University
-
Contact:
- Nicole T Nguyen, MA
- Email: nicole.tp.nguyen@vumc.org
-
Contact:
- Jennifer N Vega, PhD
- Email: jennifer.n.vega.1@vumc.org
-
Principal Investigator:
- Jennifer N Vega, PhD
-
Sub-Investigator:
- Paul A Newhouse, MD
-
Sub-Investigator:
- Sarah S Morimoto, PsyD
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Description
Inclusion Criteria:
All participants will:
- between 35 and 80 years of age
- have been diagnosed with noninvasive or invasive breast cancer
- have undergone treatment with systemic chemotherapy within the last 1- 8 years
- endorse persistent CRCI subjective complaints
- have no active unstable medical condition
- fluent in and able to read English.
Exclusion Criteria:
Participants will be excluded for
- any active neurologic or untreated/non-remitted psychiatric disease, (e.g. active major depression or another major psychiatric disorder as described in DSM-5)
- clinically significant cognitive impairment identified on cognitive screening, diagnosis of mild cognitive impairment or dementia
- history of significant head trauma followed by persistent neurologic deficits
- history of alcohol or substance abuse or dependence within the past 2 years (DSM-5 criteria)
- any significant systemic illness or unstable medical condition which could lead to difficulty complying with the protocol
- Use of any investigational drugs within 30 days or 5 half-lives, whichever is longer, prior to screening
- red-green color blindness
- Use of certain CNS active medications (e.g. antidepressants) will be permitted, provided dosing has been stable for at least 3 months.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Neuroplasticity-based Computerized Cognitive Remediation
Behavioral: Neuroplasticity-based Computerized Cognitive Remediation The nCCR has two major components: Bottom up and Top down training.
|
Behavioral: Neuroplasticity-based Computerized Cognitive Remediation The nCCR has two major components: Bottom up and Top down training.
|
Active Comparator: Education Comparison Control
The education control condition is a learning-based approach that utilizes DVDs on history, art, science, etc.
This active condition is comparable to nCCR in length of exposure, audio-visual presentation, computer use and contact with research staff.
|
The education control condition is a learning-based approach that utilizes DVDs on history, art, science, etc.
This active condition is comparable to nCCR in length of exposure, audio-visual presentation, computer use and contact with research staff.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Assess whether nCCR training produces change in subjective cognitive complaints breast cancer survivors with CRCI.
Time Frame: 6-weeks
|
Paired samples t-tests will be used to assess FACT-Cog PCI Scores. We hypothesize that nCCR treatment will improve FACT-Cog scores in breast cancer patients with persistent CRCI over 6 weeks of treatment compared to the education control group. The primary measure used to assess subjective cognitive performance was the Functional Assessment of Cancer Therapy-Cognitive Function (FACT-Cog) scale and evaluates memory, concentration, mental acuity, verbal fluency, functional interference, and multitasking ability. At baseline and post-treatment visits, participants rated on a 5-point Likert scale how they assessed various aspects of their cognitive functioning over the last 7 days. Higher scores indicate better ratings of cognitive functioning. Higher scores indicate better ratings of cognitive functioning. |
6-weeks
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Assess whether 6-weeks of nCCR training produces change in cognitive performance on neuropsychological measures in breast cancer survivors with CRCI.
Time Frame: 6-weeks
|
Paired samples t-tests will be used to assess Trail Making Test performance. We hypothesize that nCCR treatment will improve Trail Making Test performance in breast cancer patients with persistent CRCI over 6 weeks of treatment compared to the education control group. The Trail Making Test (TMT) is widely used in both research and clinical settings as a test of some aspects of executive function. Subtracting TMT A completion time from that of TMT B (TMT B-A) is thought to allow the relative contributions of visual search and psychomotor speed to be parsed from the more complex executive functions (such as cognitive flexibility) required to alternate between numbers and letters. Lower scores indicated better cognitive functioning. |
6-weeks
|
Collaborators and Investigators
Collaborators
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- 211521
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Chemotherapy-Related Cognitive Impairment
-
Vanderbilt University Medical CenterUniversity of UtahCompletedCancer Survivors | Chemotherapy-related Cognitive ImpairmentUnited States
-
University of AberdeenNHS GrampianRecruiting
-
University Medicine GreifswaldUniversity of GreifswaldRecruitingBreast Cancer | Cognitive ImpairmentGermany
-
University of PittsburghNational Cancer Institute (NCI); National Institutes of Health (NIH)Recruiting
-
Vanderbilt University Medical CenterCompletedBreast Cancer | Chemotherapy-related Cognitive Impairment | Chemo Fog | Chemo Brain | ChemobrainUnited States
-
Jay F. Piccirillo, MDBarnes-Jewish Hospital; Washington University Siteman Cancer CenterCompleted
-
NYU Langone HealthCompletedBreast CancerUnited States
-
Rachel MillerOffice of US Army Medical Research and Material CommandCompletedChemotherapy-induced Cognitive ImpairmentUnited States
-
Posit Science CorporationCompletedBreast Cancer | Memory Disorders | Cognitive SymptomsUnited States
-
University of UtahActive, not recruiting
Clinical Trials on Neuroplasticity-based Computerized Cognitive Remediation
-
Vanderbilt University Medical CenterRecruiting
-
Vanderbilt University Medical CenterUniversity of UtahCompletedCancer Survivors | Chemotherapy-related Cognitive ImpairmentUnited States
-
Stony Brook UniversityNational Multiple Sclerosis SocietyUnknownMultiple SclerosisUnited States
-
Weill Medical College of Cornell UniversityUnknownMajor Depressive Disorder | Major Depressive EpisodeUnited States
-
Assistance Publique Hopitaux De MarseilleCompletedChildren Born Extremely Premature | Disturbance of Visuo-spatial Working MemoryFrance
-
Stony Brook UniversityNovartisCompletedMultiple Sclerosis | Cognitive Deficits | Gilenya Modifying Therapy for MSUnited States
-
Queen's UniversityPfizerCompleted
-
Science and Research Centre KoperAlbert Einstein College of Medicine; University of Primorska; Vrije Universiteit...CompletedEffects of Cognitive Intervention on Cognition, Mobility and Brain Electrocortical Activity (GIBKOP)Cognitive Impairment | Aging | Cognitive Decline | Motor Coordination or FunctionSlovenia
-
NRG OncologyNational Cancer Institute (NCI)RecruitingBreast Cancer | Cognitive ImpairmentsUnited States
-
New York State Psychiatric InstituteNational Institute of Mental Health (NIMH); Columbia UniversityCompletedSchizophrenia | Schizoaffective DisorderUnited States