Effects of Two Physical Exercise Protocols on Cognition and Physical Performances in Elderly Over 80 Years

Effects of Two Physical Exercise Protocols on Cognition and Physical Performances in Oldest Old: a Randomized Controlled Trial

The purpose of this study is to compare the effects of different trainings on cognition and physical performances in elderly over 80 years.

Study Overview

• Status: Completed
• Conditions: Sedentary
• Intervention / Treatment: Other: Resistance training; Other: Multicomponent training

Detailed Description

Purpose: To compare the effects of 16-week multicomponent and resistance trainings on cognition and physical performances related to falls in oldest old people living in community; to analyze the same variables after 6-week detraining. Method: We conducted a randomized controlled trial with 69 community elderly over 80 years, sedentary and without cognitive disorder. Participants were allocated to control, multicomponent training or resistance training group. The multicomponent group performed a protocol involving warm-up, aerobic, strength, balance and cool-down exercises. The resistance group underwent to strength exercises using six machines: leg press, chest press, calf, back extension, abdominal and rowing. The control group did not perform any intervention. The trainings had progressive intensity, lasted 16 weeks and included three 1-hour sessions per week. The participants were evaluated at baseline, at the end of 16-week training and at 6-week detraining. The assessment consisted of anamnesis, depression (Geriatric Depression Scale), cognition (Montreal cognitive assessment), dual task walking (associated to cognitive and motor tasks), balance (unipedal and tandem tests), strength of lower limbs (sit-to-stand test) and history of falls. For statistical analysis by intention to treat, we adopted a significance level of α=0.05.

• Study Type: Interventional
• Enrollment (Actual): 69
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Brazil
  • São Paulo
    • São Carlos, São Paulo, Brazil, 13565-905
      • Universidade Federal de Sao Carlos

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 80 years to 95 years (Older Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• age between 80 and 95 years old
• live in community
• sedentary lifestyle
• ability to walk without help from another person with/without aid walking

Exclusion Criteria:

• any cardiovascular or infectious comorbidity described in the absolute contraindications of the Physical Activity Readiness Medical Examination
• Relative contraindications of cognitive, neurological and/or musculoskeletal comorbidities which make participation in protocols impossible
• Score in mini-state examination mental below the cutoff score designated by education level.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Factorial Assignment
• Masking: None (Open Label)

Number of Arms

3

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Resistance training	Other: Resistance training; The resistance training was subjected to a strength training using weight machines adapted for elderly. The protocol followed three sets of 10 to 12 maximal repetitions, moderate speed (two seconds for the shortening phase and three seconds for the elongation phase) and one minute for rest interval between sets.
Experimental: Multicomponent training	Other: Multicomponent training; The multicomponent training consisted of individuals subjected to a multicomponent exercise program: 5 minute warm up, 20 minutes of aerobic exercise, 15-20 minutes of strength exercises, 10 minutes of coordination, agility and balance exercises and 5 minute of cool-down.
No Intervention: Control Group; The Control Group did not realize any intervention.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Changes from baseline in lower limbs strength after 16 weeks of training and 6 weeks of detraining	Lower limbs strength was assessed by 5 times sit-to-stand test.	Assessed at baseline, after 16 weeks of training and 6 weeks of detraining
Changes from baseline in balance after 16 weeks of training and 6 weeks of detraining	Balance was assessed by unipedal test and tandem test.	Assessed at baseline, after 16 weeks of training and 6 weeks of detraining
Changes from baseline in dual task walking after 16 weeks of training and 6 weeks of detraining	Dual task was assessed by Timed Up and Go test with a cognitive task (speak day of week in reverse order) and motor task (carry a cup of water).	Assessed at baseline, after 16 weeks of training and 6 weeks of detraining
Changes from baseline in cognition after 16 weeks of training and 6 weeks of detraining	Cognition was evaluated by Montreal Cognitive Assessment.	Assessed at baseline, after 16 weeks of training and 6 weeks of detraining.

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Changes from baseline in number of falls after 16 weeks of training and 6 weeks of detraining	Presence of falls was assessed by falls calendar and phone calls.	Assessed at baseline, during 16 weeks of training and 6 weeks of detraining.
Changes from baseline in depression after 16 weeks of training and 6 weeks of detraining	Depression was assessed by abbreviated Geriatric Depression Scale.	Assessed at baseline, during 16 weeks of training and 6 weeks of detraining.

Collaborators and Investigators

• Sponsor: Universidade Federal de Sao Carlos
• Investigators: Principal Investigator: Juliana H Ansai, specialist, Universidade Federal de Sao Carlos

Study record dates

Study Major Dates

• Study Start: August 1, 2012
• Primary Completion (Actual): September 1, 2013
• Study Completion (Actual): September 1, 2013

Study Registration Dates

• First Submitted: October 31, 2013
• First Submitted That Met QC Criteria: November 6, 2013
• First Posted (Estimate): November 14, 2013

Study Record Updates

• Last Update Posted (Estimate): November 14, 2013
• Last Update Submitted That Met QC Criteria: November 6, 2013
• Last Verified: November 1, 2013

More Information

Terms related to this study

• Keywords: Exercise; Balance; Randomized controlled trial; Cognition; aged, 80 and over
• Other Study ID Numbers: Ansai-01