- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02036073
Effect of Erythropoietin on Preterm Brain Injury (EPO)
January 13, 2014 updated by: Huiqing Sun, Zhengzhou Children's Hospital, China
EPO has been safely used for prevent preterm anemia and recent studies have shown the neuroprotective effect.
Our hypothesis is that EPO could prevent preterm brain injury.
The aims of this study include: to investigate the safety and efficacy of EPO by using 500u/kg higher than the dose of anemia treatment (250u/kg); to evaluate the effect of EPO on neurodevelopment in preterm infants; to detect biological indicators and explore the neuroprotective mechanism of EPO.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Detailed Description
Periventricular leukomalacia (PVL) is one of the most common brain injuries that occur in preterm infants, which is related with the development of cerebral palsy.
The current therapy is only supportive to maintain the live sign stable.
There is no effective therapeutic strategy for preterm brain injury.
Erythropoietin (EPO) has been shown to be protective against hypoxic-ischemic and inflammatory injuries in animal models of brain injury, and clinical trials of neonatal hypoxic ischemic brain injury.
Furthermore, recombinant human Epo (rhEpo) has been widely used in preterm infants to prevent or treat the anemia of prematurity during the past decade.
It has been considered to be safe and well tolerated in preterm infants.
However, there is no conclusion yet if the EPO has the effect to prevent preterm brain injury.
The purpose of the study was whether the rhEpo (500 U/kg) given to very preterm infants (gestation age < 32 weeks) within 24h after birth and subsequently each other day for2 week possesses neuroprotective properties.
Very preterm infants with gestational age of < 32 weeks and admit to our NICU are eligible for enrollment.
After informed consent is obtained, infants will be randomly assigned to either EPO group or vehicle group.
The primary short-term outcome measures are brain injury (intraventricular hemorrhage (IVH) and periventricular leukomalacia (PVL)) and ROP.
The long term outcomes are whether rhEpo in very preterm infants finally improves neurodevelopmental outcome at 18 months corrected age.
Study Type
Interventional
Enrollment (Actual)
490
Phase
- Phase 4
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
Henan
-
Zhengzhou, Henan, China, 450053
- Zhengzhou Children'S Hospital
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
1 day to 2 months (Child)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Preterm infants admitted to the NICU with gestational age <32 weeks
- birth weight <1500g and less than 72hours of age
Exclusion Criteria:
1. Infants with genetic metabolic diseases
2. Congenital abnormalities
3. Pneumothorax
4. Grade III-IV intracranial hemorrhage
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Prevention
- Interventional Model: Parallel Assignment
- Masking: Single
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: EPO
In EPO group, the EPO was given by 500IU/kg every other day intravenously for 2 weeks.
Recombinant human erythropoietin was configured by the hospital pharmacy intravenous Center Configuration, melted configured with saline to 1ml/kg solution.
For severe patients, they were started to treat with EPO when their vital signs, blood pressure were stable.
|
rhEPO 500U/kg was injected within 24h after birth, subsequent injection was given each other day fro 2 weeks.
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Incidence of MDI<70
Time Frame: At corrected age of 18 months
|
At corrected age of 18 months
|
Secondary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Incidence of ROP
Time Frame: At the corrected age 42 weeks
|
At the corrected age 42 weeks
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Collaborators
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
January 1, 2009
Primary Completion (Actual)
June 1, 2012
Study Completion (Actual)
December 1, 2013
Study Registration Dates
First Submitted
December 10, 2013
First Submitted That Met QC Criteria
January 13, 2014
First Posted (Estimate)
January 14, 2014
Study Record Updates
Last Update Posted (Estimate)
January 14, 2014
Last Update Submitted That Met QC Criteria
January 13, 2014
Last Verified
January 1, 2014
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- CZZ-EPO
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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