Body Responses to Bean Physical Form and "Beano" (BFE)

Effects of Bean Form and Digestive Enzyme Availability on Postprandial Responses

The aim of this study is to determine the effects of bean physical form (whole versus blended) and Beano on postprandial responses. The postprandial responses the investigators will examine include blood glucose, appetite, metabolic rate, physical symptoms, and mood. To accomplish this aim the investigators will conduct a randomized, placebo-controlled trial in overweight and obese but otherwise healthy (non-diabetic) men and women

Study Overview

• Status: Completed
• Conditions: Appetite and Glucose Responses
• Intervention / Treatment: Other: blended lentils; Other: whole lentils; Other: no lentils

• Study Type: Interventional
• Enrollment (Actual): 14
• Phase: Not Applicable

Contacts and Locations

Study Locations

• United States
  • Indiana
    • West Lafayette, Indiana, United States, 47907
      • Purdue University

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 55 years (Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Aged 18-55 years old
• Body mass index (BMI) 18.5-40 kg/m2
• Generally healthy
• A non-smoker
• Any ethnicity
• Free of chronic diseases and not taking medications or dietary supplements known to affect energy regulation or appetite

Exclusion Criteria:

• Beano drug label warnings including galactosemia, severe liver or kidney disease, allergies or sensitivities to any of the ingredients in Beano
• Peri and postmenopausal women
• Pregnant or lactating women (currently and within the past 1 year)
• Currently dieting or consuming unusual or a medically prescribed diet
• Net weight loss or gain (>5 lbs) within the last six months
• Consuming 1/2c per day or more of legumes, not including peanuts
• Having taken Beano any time in the past 3 months
• Extreme problems digesting beans
• Fasting glucose >126 mg/dl
• Blood pressure >140/90 mmHg
• Moderate intensity or higher intensity exercise > 6 h/wk
• Predicted energy requirement < 2000 kcal/d or >4000 kcal/d

Study Plan

How is the study designed?

Design Details

• Allocation: Randomized
• Interventional Model: Crossover Assignment
• Masking: Double

Number of Arms

6

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: alpha-gal & blended lentils; 3 capsules of alpha-gal taken with blended lentils	Other: blended lentils; blended lentils burritto breakfast
Experimental: alpha-gal & whole lentils; 3 calpsules of alpha-gal taken with whole lentils	Other: whole lentils; whole lentils breakfast burritto
Experimental: alpha-gal & no lentils; 3 capsules of alpha-gal taken with no lentils control	Other: no lentils; No lentils control breakfast burritto
Placebo Comparator: Placebo & blended lentils; 3 capsules of placebo taken with blended lentils	Other: blended lentils; blended lentils burritto breakfast
Placebo Comparator: Placebo & whole lentils; 3 capsules of placebo taken with whole lentils	Other: whole lentils; whole lentils breakfast burritto
Placebo Comparator: Placebo & no lentils; 3 capsules of placebo taken with no lentils control	Other: no lentils; No lentils control breakfast burritto

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Appetite	Subjects were given an appetite questionnaire to complete at time 0, 20, 40, 60, 120 and 180	3 hours

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Blood glucose	Finger prick blood were taken at time 0, 20, 40, 60, 120 and 180 for glucose measurement using a glucometer	3 hours
fasting and postprandial energy expentidure	Fasting energy expenditure was measured for thirty minutes before meal and beano intervensions were given and at postprandial time points 20, 40, 60, 120 and 180, postprandial energy expenditure was measured for 15 minutes at each time point	4 hours
gastrointestinal symptoms	At timepoints 0, 20, 40, 60, 120 and 180, gastroinstinal symptoms were assessed using a questionnaire	3 hours

Collaborators and Investigators

• Sponsor: Purdue University

Publications and helpful links

General Publications

• Anguah KO, Wonnell BS, Campbell WW, McCabe GP, McCrory MA. A blended- rather than whole-lentil meal with or without alpha-galactosidase mildly increases healthy adults' appetite but not their glycemic response. J Nutr. 2014 Dec;144(12):1963-9. doi: 10.3945/jn.114.195545. Epub 2014 Oct 8.

Study record dates

Study Major Dates

• Study Start: August 1, 2011
• Primary Completion (Actual): October 1, 2012
• Study Completion (Actual): October 1, 2012

Study Registration Dates

• First Submitted: April 8, 2014
• First Submitted That Met QC Criteria: April 9, 2014
• First Posted (Estimate): April 10, 2014

Study Record Updates

• Last Update Posted (Estimate): April 10, 2014
• Last Update Submitted That Met QC Criteria: April 9, 2014
• Last Verified: April 1, 2014

More Information

Terms related to this study

• Other Study ID Numbers: 1107011010