- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02172677
The Influence of Collective Schemas on Individual Memory (MULTIBRAIN_1)
November 3, 2017 updated by: Institut National de la Santé Et de la Recherche Médicale, France
ETUDE D'IMAGERIE PAR RESONANCE MAGNETIQUE FONCTIONNELLE CHEZ LE SUJET SAIN DES RELATIONS ENTRE MEMOIRE COLLECTIVE ET INDIVIDUELLE
Schemas describe mental structures storing recurrent and organized pattern of information.
Schemas may have a strong influence on the process of storing and retrieving new information into memory.
Previous approaches in the cognitive neuroscience of memory have entirely focused on the individual dimension of preexisting schemas.
In the real world though, much of our experiences and knowledge are collective or shared.
Such social-cultural frameworks stored in collective memory may also reshape and reconfigure the construction of individual memories.
Attempting to ascertain the influence of collective schema on the neural substrates of individual memories using cutting-edge brain imaging methods represents the challenge that MULTIBRAIN seeks to tackle.
To achieve this goal, we will record brain activity in a group of 24 participants while there are remembering pictures from a tour at the World War II Memorial of Caen.
This study will seek to identify brain areas of the prefrontal cortex encoding the organization of knowledge in collective memory using multivariate analyses of brain patterns of activation, and then to understand how such regions might modulate the recruitment of the hippocampus during episodic memory retrieval using analyses of effective connectivity.
The organization of knowledge in collective memory is measured in parallel through 1) the analysis of French social memory of World War II using a corpus of 100 000 television and radio shows from the National Institute of Audiovisual, and 2) an internet task measuring the organization of individual knowledge in a large group of individuals that will allow to separate shared from non-shared memories of the World War II.
Once collected, these data will help us to understand how collective schemas may reconfigure the organization of individual memories.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Study Type
Interventional
Enrollment (Actual)
27
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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Caen, France, 14074
- GIP Cyceron
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
20 years to 38 years (ADULT)
Accepts Healthy Volunteers
Yes
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Healthy participants between 20 and 38 years old
- Affiliated to the French national health care system
- French native speaker
- Participated in a tour trip at the Memorial of Caen within the last 3 months
- Right-handed
- At least 2 years of education after graduating from high school
- Body mass < 30kg/m2
- Signed written consent form
Exclusion Criteria:
- Pregnancy or intent to get pregnant
- Person deprived of their liberty
- Person hospitalized without consent
- Minor
- Protected adults or people unable to give informed consent
- Person subjected to an exclusion period related to another protocol
- History of neurological or psychiatric disorders or existence of traumatic brain injury with loss of consciousness for more than one hour
- History of cancer with the last 5 years, excluding squamous cell carcinomas
- Alcoholism, antecedents of chronic alcoholism or drugs abuse
- Severe psychiatric disorders (according to DSM V diagnostic criteria) or psychological troubles which could affect participant's judgment
- Use of medication that may interfere with cognitive or cerebral functioning
- Presence of visual or hearing troubles that may compromise participant's ability to participate in the study
- MRI Contraindications
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: BASIC_SCIENCE
- Allocation: NA
- Interventional Model: SINGLE_GROUP
- Masking: NONE
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
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Experimental: Healthy participants
Structural and functional MRI and memory assessment
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Blood Oxigen Level Dependent (BOLD) response as measured with fMRI
Time Frame: 1 hour
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1 hour
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Secondary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Episodic memory performances - % of accuracy
Time Frame: 1 hour
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1 hour
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Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
October 1, 2014
Primary Completion (Actual)
October 14, 2016
Study Completion (Actual)
October 14, 2016
Study Registration Dates
First Submitted
June 16, 2014
First Submitted That Met QC Criteria
June 20, 2014
First Posted (Estimate)
June 24, 2014
Study Record Updates
Last Update Posted (Actual)
November 6, 2017
Last Update Submitted That Met QC Criteria
November 3, 2017
Last Verified
October 1, 2017
More Information
Terms related to this study
Other Study ID Numbers
- C13-46
- 2014-A00126-41 (Registry Identifier: ID RCB)
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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