The Lipid Profile of the Skin Surface in Acne (Acne)

May 25, 2017 updated by: University of California, Davis
The purpose of this study is to evaluate the differences in the skin lipid profile of patients with and without acne. Secondly, the goal is to learn more about what the effects of retinoinds (topical and systemic) are on the the skin lipid profile. We hypothesize that the skin lipid profile of subjects with acne will be lower in inflammatory lipids in comparison to subjects without acne.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

Skin lipid profile will be conducted via sebutapes- adhesive tapes that painlessly absorbs sebum from the face. These tapes will be placed on the face for 1 hour. A photograph of the face will be taken during each study visit. A sebumeter will also be used to measure skin sebum secretion rate.

Study Type

Observational

Enrollment (Actual)

30

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United States
    • California
      • Davis, California, United States, 95616
        • Dermatology Research Area
      • Sacramento, California, United States, 95816
        • UC Davis Department of Dermatology

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

12 years to 30 years (ADULT, CHILD)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Sampling Method

Non-Probability Sample

Study Population

Subjects will be from the UC Davis Dermatology Clinic, surrounding dermatology clinics, from the UC Davis undergraduate campus, and from the California State University Sacramento campus.

Description

Inclusion Criteria:

  • age 12 to 30 years
  • have been prescribed tretinoin OR isotretinoin

Exclusion Criteria:

  • those who have taken isotretinoin (systemic)
  • those who used tretinoin or other topical retinoid within two weeks of starting the study
  • those with seborrheic dermatitis, rosacea, or polycystic ovary syndrome
  • those who are pregnant, prisoners, or cognitively impaired
  • those who do not fit the inclusion criteria

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Healthy Group
The subjects in this group do not have a history of acne.
Acne Group, Topical Retinoid
These subjects have been prescribed a topical retinoid for their acne. They will participate in the study for a period of 1 month.
Drug: Tretinoin or Adapalene
Subjects will apply a pea sized amount of topical retinoid cream once daily at night for 30 days. Subjects will return for a follow-up visit.
Other Names:
  • Retin A
Acne Group, Isotretinoin
These subjects have been prescribed isotretinoin for their acne. They will participate in the study for a period of 5-6 months.
Drug: Isotretinoin
Subjects will take one pill once daily for 5 months. Subjects will return after 1 month and after 4-5 months of treatment for skin lipid profiling.
Other Names:
  • Accutane

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Skin lipid profile of acne and healthy patients
Time Frame: baseline visit
Compare the skin lipid profile of acne and healthy patients at baseline
baseline visit

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Skin lipid profile of acne patients after treatment
Time Frame: at 1 month and 4-5 months of treatment
Patients in the topical retinoid group will have their lipids evaluated after 1 month of treatment. Patients in the systemic retinoid (isotretinoin) group will have their lipids evaluated after 1 and 4-5 months of treatment.
at 1 month and 4-5 months of treatment

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University of California, Davis

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Helpful Links

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

November 1, 2013

Primary Completion (Actual)

May 1, 2015

Study Completion (Actual)

July 1, 2015

Study Registration Dates

First Submitted

June 30, 2014

First Submitted That Met QC Criteria

June 30, 2014

First Posted (Estimate)

July 2, 2014

Study Record Updates

Last Update Posted (Actual)

May 30, 2017

Last Update Submitted That Met QC Criteria

May 25, 2017

Last Verified

May 1, 2017

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 531506

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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