Aquatic and Land Aerobic Training, Cardiorespiratory and Metabolic Variables in Cardiorespiratory Diseases

Effects of Aquatic and Land Aerobic Training on Body Composition and Cardiorespiratory and Metabolic Variables in Patients With Cardiorespiratory Diseases

In the pathophysiological process of coronary artery disease (CAD), are present, autonomic dysfunction and reduced functional capacity. Studies showed that physical training (PT) is critical in the treatment of CAD by promoting beneficial effects. Although water based exercises program have been documented in patients with various cardiovascular diseases, the most of studies among patients with CAD used land based exercises programs. OBJECTIVE: To evaluate and compare the effects of aerobic water (WPT) and land (LPT) based PT on autonomic modulation of heart rate (HR), body composition and cardiorespiratory and metabolic variables in patients with CAD. METHODS : 40 men between 50 and 70 years old with CAD diagnosed by coronary angiography showing obstruction greater than 50% and underwent angioplasty will be evaluated in 4 stages; 1) immediately after angioplasty, clinical assessment, body composition analysis and recording of HR and NN intervals during rest. 2) The components of step 1) will be repeated after three month, adding the record of HR and NN before, during and after the Valsalva maneuver, spirometry and cardiopulmonary exercise testing. 3) Volunteers will be randomly divided into two groups, WPT and LPT for 48 sessions. 4) The components of step 2) are repeated after each period of 12 sessions. Thus, it is expected that WPT promote beneficial physiological adaptations in CAD patients with obstruction greater than 50%.

Study Overview

• Status: Unknown
• Conditions: Arteriosclerosis, Coronary
• Intervention / Treatment: Other: Exercise, Aerobic (Water based); Other: Land Group

Detailed Description

1. Immediately after angioplasty, the volunteers will be subject to an assessment (Assessment 0), which will consist of:

   • History: personal data, lifestyle and food, family history, current and previous history of disease.
   • Physical examination: cardiac and lung auscultation,measurement of heart rate (HR), blood pressure (BP), body weight and height.
   • Analysis of body composition by bioelectrical impedance analysis.
   • Registration of HR and NN intervals (NN) during rest, in the supine and sitting positions.
   • biochemical blood tests: complete blood count, blood glucose, total cholesterol, LDL and HDL cholesterol, triglycerides, and C-reactive protein ultrasensitive.
   • Recording of HR and NN during rest in the supine position, sitting, standing and during respiratory sinus arrhythmia maneuver.
2. Three months after the "Assessment 0", the volunteers will be subject to an assessment (initial Assessment) prior to physical training program. Will be repeated all assessments performed in the "Assessment 0" plus the record of HR and R-Ri before, during and after the Valsalva maneuver, spirometry and cardiopulmonary exercise test (CPET). This is a submaximal CPET performed on a treadmill, in order to verify and identify possible changes in hemodynamic, electrocardiographic induced to physical exertion, their aerobic functional capacity as well as to prescribe physical training protocol.
3. After this assessment, the volunteers will be randomly assigned to one of two groups, aerobic water (WPT) or land (LPT) based physical training.
4. Components of "Initial Assessment" will be repeated at the end of each month of physical training (Revaluation 1, 2 and 3) and the end (Final Assessment).

• Study Type: Interventional
• Enrollment (Anticipated): 40
• Phase: Early Phase 1

Contacts and Locations

Study Locations

• Brazil
  • São Paulo
    • Piracicaba, São Paulo, Brazil, 55
      • Universidade Metodista de Piracicaba

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 50 years to 70 years (ADULT, OLDER_ADULT)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: Male

Description

Inclusion Criteria:

• diagnosis by angiography
• sedentaries
• family story of cardiac disease
• obesity

Exclusion Criteria:

• frequent arrhythmias at rest
• triggered by physical effort
• unstable angina
• chronic obstructive pulmonary disease
• insulin-dependent diabet
• renal failure
• sequel of stroke
• uncontrolled hypothyroidism
• water phobia
• skin infections, allergic reactions to chlorine,
• urinary incontinence and
• musculoskeletal and neuromuscular disorders precluding physical tests and training sessions

Study Plan

How is the study designed?

Design Details

• Primary Purpose: TREATMENT
• Allocation: RANDOMIZED
• Interventional Model: PARALLEL
• Masking: DOUBLE

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
EXPERIMENTAL: Exercise, Aerobic (Water based); Patients of this group will be submitted to an aerobic water based physical training	Other: Exercise, Aerobic (Water based); Patients of this group will be submitted to an aerobic water based physical training
ACTIVE_COMPARATOR: Land Group; Patients of this group perform physical training on bicycle.	Other: Land Group; Patients of this group perform physical training on bicycle.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change in autonomic system modulation	Change in autonomic system modulation in assess by comparing the heart rate variability at baseline and after a 16 weeks of aerobic water and land based physical training.	baseline and 16 weeks

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change in body composition	Change in body composition is assess by comparing the body composition at baseline and after a 16 weeks of aerobic water and land based physical training.	16 weeks

Other Outcome Measures

Outcome Measure	Measure Description	Time Frame
Oxygen uptake	Change in oxygen uptake is assessed by comparing the oxygen uptake at baseline and after a 16 weeks of aerobic water and land based physical training.	16 Weeks

Collaborators and Investigators

• Sponsor: Universidade Metodista de Piracicaba

Study record dates

Study Major Dates

• Study Start: September 1, 2014
• Primary Completion (ANTICIPATED): July 1, 2015
• Study Completion (ANTICIPATED): February 1, 2018

Study Registration Dates

• First Submitted: July 15, 2014
• First Submitted That Met QC Criteria: July 23, 2014
• First Posted (ESTIMATE): July 24, 2014

Study Record Updates

• Last Update Posted (ESTIMATE): July 24, 2014
• Last Update Submitted That Met QC Criteria: July 23, 2014
• Last Verified: July 1, 2014

More Information

Terms related to this study

• Keywords: Autonomic Nervous System, Body composition, Oxygen Uptake,; Water Based Physical Training, Land Based Physical Training.
• Additional Relevant MeSH Terms: Heart Diseases; Cardiovascular Diseases; Vascular Diseases; Arterial Occlusive Diseases; Coronary Disease; Coronary Artery Disease; Myocardial Ischemia; Arteriosclerosis
• Other Study ID Numbers: 03/13; 190729/2011-2 (OTHER_GRANT: 190729/2011-2)