The Effects of Lutein and Zeaxanthin Supplementation on Vision in Patients With Albinism

Lead Sponsor: Johns Hopkins University

Collaborator: Clark Charitable Foundation Inc.

The LUVIA study is a randomized placebo-controlled trial designed to investigate the effects of lutein and zeaxanthin supplementation on macular pigment and visual function in ocular or oculocutaneous albinism. Lutein and zeaxanthin supplementation will be compared to a placebo (no treatment) gel pill over the period of 12 months, with study visits approximately every 3 months for the first year and a final visit 18 months after enrollment.

Ocular and oculocutaneous albinism represent a spectrum of disorders with absent or significantly diminished amount of melanin either across different body tissues - skin, hair, eye (Oculocutaneous Albinism 1 and 2), or exclusively in eye tissues only (Ocular Albinism 1) .

The functionality and the clinical findings are diverse (the phenotype), and no direct correlation has been established to the underlying mutations (genotype).

The common ocular phenotype includes iris transillumination, foveal hypoplasia, nystagmus, reduced visual acuity, refractive error, photosensitivity and abnormal development of the visual pathways with characteristic abnormal routing of ganglion cell axons in the chiasma, resulting in abnormal visually evoked potentials. Current treatment options are limited to optical methods and low vision aids.

The mechanism of melanin pigment formation in the RPE cells and its role in the visual pathways and structures development is not completely understood, but a correlation was found between the amount of fundus pigmentation and visual function in albino patients. The absent pigmentation within the retinal pigment epithelium (RPE) may thus contribute to visual performance deficits.

The macular pigment (MP) consists of two main carotenoids, lutein and zeaxanthin, which are concentrated in the macular region of the retina. MP is hypothesized to function via a protective mechanism by absorbing blue light incident on the retina thereby reducing oxidative damage to the underlying photoreceptors. It is also thought to improve visual function via reduction of chromatic aberration and glare. It is currently unclear as to how the variability in macular pigment optical density (MPOD) affects congenital retinal conditions. The MP would, however, be a hypothetical and good candidate to improve visual performance - simply by increasing pigmentation, reducing light scatter and thus glare sensitivity.

As this pigment is not produced in the retina, but is absorbed via diet, it can be manipulated by alteration in diet and supplementation thereby providing potential therapy for retinal diseases. It is however necessary first to see if MPOD levels are measurable in this disorder before dietary advice can be provided after completion of the LUVIA study. Further to this, evaluation of both the structural and functional properties of the retina will provide greater insight into the possible function of MP in this retinal disease including whether supplementation would be of benefit.

• Ocular Albinism (OA)
• Oculocutaneous Albinism (OCA)

Intervention Type: Dietary Supplement

Intervention Name: Lutein plus Zeaxanthin

Description: dose: two softgels once a day with a meal

Arm Group Label: Lutein plus Zeaxanthin

Other Name: EyePromise® Lutein + Zeaxanthin (ZeaVision, LLC)

Intervention Type: Dietary Supplement

Intervention Name: Placebo

Description: two softgels once-daily with a meal

Arm Group Label: Placebo softgels

Other Name: placebo softgels

Criteria:

Inclusion Criteria:

- Age of 12 years old and older

- Clinical and/or genetic diagnosis of ocular or oculocutaneous albinism

- Ocular media allowing acceptable visualization of the retina.

- Ocular media allowing acceptable quality of the ocular coherence tomography (OCT) and/or fundus autofluorescence (FAF) scans.

- At least one reliable central macular pigment optical density (MPOD) measurement captured on the enrollment visit in at least one eligible eye

- Best corrected visual acuity of 20/200 or better in one or both eligible eyes (eyes that confirmed to be eligible by the MPOD testing).

Exclusion Criteria:

- Persons taking lutein and/or zeaxanthin supplements over the past 6 months

- Pregnant or planning to become pregnant

- Evidence of present or past retinal macular condition other than congenital foveal hypoplasia

- History of gastrointestinal disease that would interfere with absorption of lutein and zeaxanthin

- Participation in a clinical trial requiring visual testing or administration of a drug (marketed or investigational) within 60 days before entry in the study (the day informed consent is signed)

- Inability to communicate or cooperate with the investigator due to cognitive impairment or poor general health

- Any other condition which, in the opinion of the investigators, is likely to interfere with the successful collection of the measures required for the study

Gender: All

Minimum Age: 12 Years

Maximum Age: N/A

Healthy Volunteers: No

United States

December 2018

Type: Sponsor

• ocular albinism (OA)
• oculocutaneous albinism (OCA)
• macular pigment
• visual function

• Albinism
• Albinism, Oculocutaneous
• Albinism, Ocular

Label: Lutein plus Zeaxanthin

Type: Experimental

Description: Participants randomized to this arm will receive 20 mg of Lutein (L) plus 20 mg of Zeaxanthin (Z) per day: Two pills (10 mg L+ 10 mg Z per pill) for the duration of one year.

Label: Placebo softgels

Type: Placebo Comparator

Description: Participants randomized to this arm will receive two pills per day of placebo-gels corresponding to the active compound in look and feel for the duration of one year

Allocation: Randomized

Intervention Model: Parallel Assignment

Primary Purpose: Treatment

Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)