Predicting RadIotherapy ReSponse of Rectal Cancer With MRI and PET (PRISM)

October 26, 2022 updated by: Professor Andrew Kneebone, Royal North Shore Hospital
The purpose of this study is to investigate if PET/CT and MRI scans performed early in treatment and six weeks after treatment can predict the response of rectal cancer following chemotherapy and radiotherapy. This will help doctors to better tailor treatments for rectal cancer in the future.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

Bowel cancer is the second most prevalent cancer in Australia with rectal cancer the most common subgroup, representing 5% of all cancer diagnoses in 2008 [1]. Rectal cancer also accounts for 4.6% of all cancer deaths in New South Wales [1]. All rectal cancer that is T3/4 or node positive on pre-operative assessment should be considered for pre-operative therapy, which has been shown to significantly improve local control compared to postoperative chemoradiation. [2]. Pre-operative chemoradiation is standard pre-operative treatment at the Northern Sydney Cancer Centre with approximately 40 patients/year receiving this treatment. Surgery is normally performed 6-8 weeks following chemoradiation.

One of the unique opportunities with rectal cancer is that histopathological analysis of the resected specimen gives an accurate assessment of the response of the tumour to pre-operative chemoradiation. Those tumours having a pathologic complete response (pCR) are known to have an excellent long-term outcome.

Data from the department of Radiation Oncology at Northern Sydney Cancer Centre demonstrates that only 17% of patients experience a pCR, which is in keeping with other series [4]. In this study of 48 patients, 38% showed evidence of tumour shrinkage 2 weeks into treatment as demonstrated on a Cone Beam CT scan taken during radiotherapy. 44% of these patients demonstrated a pCR following surgery. In the remaining 62%, none of these patients had a pCR. This confirms the principle that early response during radiation based only on gross tumour shrinkage can be a powerful predictor of subsequent response.

Assessing response during Cone Beam CT is very subjective and not possible on all patients. Furthermore it may be possible to better predict those likely to have a complete response with alternate imaging modalities. There is emerging data that functional and microstructural imaging modalities can also be used to predict and assess treatment response prior to, during and following the delivery of pre-operative chemoradiation for locally advanced rectal cancer [5].

Diffusion-weighted magnetic resonance imaging (DWI) is a microstructural imaging technique that characterizes tissue based on differences in the movement of water molecules. These differences can be quantified using the apparent diffusion coefficient (ADC). The ADC has been shown to differentiate post-treatment inflammation and necrosis from recurrent or persistent tumoural tissue in rectal cancer with high specificity [6]. Pre-treatment ADC assessment with DWI has a sensitivity of 100% and specificity of 86% for detection of pCR (p=0.003) whilst treatment induced changes in ADC (measured at week 2 chemoradiation) have a sensitivity and specificity of 100% for predicting pCR (p=0.0006) [5]. Prediction of response should be improved further with the use of PET imaging. A staging 18F-FDG (18F-2-fluoro-2-deoxy-D-glucose fluorodeoxyglucose ) PET/CT has been demonstrated to provide new findings compared to contrast-enhanced CT of the thorax/abdomen/pelvis resulting in a change in the stage of disease and alteration of treatment strategy in 14% of patients [7]. F-FDG PET/CT can be more predictive of histological response and outcome than anatomic imaging alone [8]. Whilst PET Response Criteria in Solid Tumors (PERCIST) has not been shown to have predictive power on the response to neoadjuvant therapy, PET Residual Disease in Solid Tumor (PREDIST) criteria has been shown to correlate to pCR (p = 0.004) [9].

Study Type

Interventional

Enrollment (Actual)

27

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Australia
    • New South Wales
      • St Leonards, New South Wales, Australia, 2065
        • Northern Sydney Cancer Centre, Royal North Shore Hospital

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • Age > 18 years
  • T3/4 or node positive rectal cancer
  • Suitable for pre-operative chemo-irradiation and surgical resection
  • No contraindication to MRI (pacemaker, severe claustrophobia)
  • Gross visible disease on MRI
  • No contraindications to PET/CT
  • Eastern Cooperative Oncology Group (ECOG) performance status 0-2 (Karnofsky Performance Status > 70%)
  • Ability to understand and the willingness to sign a written informed consent document.

Exclusion Criteria:

  • - Previous radiotherapy to pelvis
  • Unable/unwilling to have MRI
  • Unable/unwilling to have PET/CT
  • Pregnancy, lactation or inadequate contraception
  • Known allergic reaction to FDG PET contrast
  • Pacemaker or implanted defibrillator
  • Patients with a history of psychological illness or condition such as to interfere with the patient's ability to understand requirements of the study.
  • Unwilling or unable to give informed consent

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Other
  • Allocation: N/A
  • Interventional Model: Single Group Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Assessing response with MRI + PET.

Pre-operative chemo/RT as per standard treatment. Intensity Modulated Radiotherapy (IMRT) / Volumetric Arc Therapy (VMAT) 45Gray/25 fractions with simultaneous integrated Boost of 50Gray/25 fractions + concurrent capecitabine chemotherapy.

Intervention 1 'Early MRI and PET/CT - 2 weeks after commencing chemo/RT' involves additional Multiparametric MRI + PET/CT 2 weeks into chemo/RT Intervention 2 :\'Late MRI and PET/CT 6 weeks post chemo/RT' involves additional Multiparametric MRI + PET/CT 6 weeks post chemo/RT
Other: Early MRI and PET/CT - 2 weeks after commencing chemo/RT
Patients will have an early MRI and PET/CT - 2 weeks after commencing chemo/RT. A limited range PET/CT will look at parameters: SUVmaxm PERCIST, RECIST 1.1, ΔSUV (PET1-2), ΔSUV (early -late), Glycolytic tumour volume (GTV). MRI T2 (1-3mm slice as per NS Radiology protocol and ESGAR guideline) will look at parameters: DWI & ADC value (preferably on a single camera with reproducible ADC value), Local Staging, MRF involvement, EMVI, nodal status, MR volumetry, and desmoplastic reaction.
Other Names:
  • Imaging
Other: Late MRI and PET/CT 6 weeks post chemo/RT
Patients will have late a MRI and PET/CT 6 weeks post chemo/RT. A whole body PET/CT will look at parameters: SUVmaxm PERCIST, RECIST 1.1, ΔSUV (PET1-2), ΔSUV (early -late), Glycolytic tumour volume (GTV). MRI T2 (1-3mm slice as per NS Radiology protocol and ESGAR guideline) will look at parameters: DWI & ADC value (preferably on a single camera with reproducible ADC value), Local Staging, MRF involvement, EMVI, nodal status, MR volumetry, and desmoplastic reaction.
Other Names:
  • Imaging

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Predictive value of PET/CT and MRI 2 weeks into chemo-irradiation for developing a pathologic complete response at surgery.
Time Frame: 2 years

Predictive value of PET/CT and MRI 2 weeks into chemo-irradiation for developing a pathologic complete response at surgery (Grade 0 - no viable cancer cells seen in the resection specimen).

The standard grading system employed by pathologists at Royal North Shore Hospital will be used to measure tumour regression. This is the system recommended by the RCPA synoptic report for colorectal cancer, based on Ryan R, Gibbons D, Hyland JMP, et al. Pathological response following long-course neoadjuvant chemoradiotherapy for locally advanced rectal cancer. Histopathology 2005; 47:141-6.
2 years

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Feasibility of conducting additional PET and MRI scans at 6 weeks post-treatment.
Time Frame: 2 years
This will be assessed in terms of whether PET and MR imaging approximately 6 weeks after chemo-irradiation adds any additional predictive value to imaging performed 2 weeks into treatment.
2 years
Utility of adding PET scan to the baseline staging of patients
Time Frame: 2 years
This will be measured by whether PET 2 weeks into treatment (combined with already utilised MRI) can independently predict the likelihood of a pathological complete response at surgery.
2 years
Pathologic response according to Tumour Regression Grade (TRG)
Time Frame: 2.5 years
A scoring system will be developed based on the degree of response from the PET and MRI scan at 2 weeks incorporating tumour shrinkage (PET and MR), reduction in SUV (PET) and reduction in diffusion (MR) that can best predict the "responders" and "non-responders".
2.5 years
Impact of pCR rates on long term disease control
Time Frame: 5 years
Measured in terms of loco-regional or distant recurrence by 3 years.
5 years

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Royal North Shore Hospital

Investigators

  • Principal Investigator: Andrew Kneebone, MBBS, Royal North Shore Hospital

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

September 1, 2014

Primary Completion (Actual)

December 1, 2018

Study Completion (Actual)

December 1, 2018

Study Registration Dates

First Submitted

August 13, 2014

First Submitted That Met QC Criteria

September 2, 2014

First Posted (Estimate)

September 8, 2014

Study Record Updates

Last Update Posted (Actual)

October 28, 2022

Last Update Submitted That Met QC Criteria

October 26, 2022

Last Verified

October 1, 2022

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 14-NSCCRO-P001

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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