- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02463669
The Use of Point-of-Care Ultrasound in the Diagnosis of Acute Infectious Mononucleosis in the Emergency Department
October 4, 2020 updated by: Laurie Robichaud, Jewish General Hospital
The purpose of this study is to determine if splenomegaly on point-of-care ultrasound (POCUS) is an accurate and user-friendly surrogate to the heterophile antibody test and Epstein-Barr Virus (EBV) serologies to diagnose acute mononucleosis infection in patients presenting with sore throat to the Emergency Department (ED).
Study Overview
Status
Terminated
Conditions
Intervention / Treatment
Detailed Description
The investigators seek to determine whether the presence of splenomegaly on POCUS can accurately diagnose acute infectious mononucleosis in symptomatic ED patients, and determine the feasibility of performing point-of-care ultrasound for splenomegaly by emergency physicians in the emergency department setting.
Study Type
Observational
Enrollment (Actual)
200
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
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Quebec
-
Montreal, Quebec, Canada, H3T 1E2
- Jewish General Hospital
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Montreal, Quebec, Canada, H3T 1C4
- CHU Sainte-Justine
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
10 years to 35 years (Child, Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Sampling Method
Non-Probability Sample
Study Population
Convenience sample of patients between July 2016 and October 2017.
Inclusion criteria are patients aged between 10 and 35 year-old presenting to the ED with suspected acute infectious mononucleosis.
Description
Inclusion Criteria:
- Patients aged between 10 and 35 year-old presenting to the ED with suspected acute infectious mononucleosis
Exclusion Criteria:
- Chronic infectious disorders (eg. tuberculosis, malaria, HIV, syphilis)
- Inflammatory disorders (eg. sarcoidosis, amyloidosis, systemic lupus erythematosus, Felty syndrome)
- Proliferative disorders (eg. lymphoma, leukemia, essential thrombocytopenia, polycythemia vera)
- Congestive disorders (eg: cirrhosis, portal hypertension, right heart failure, congenital heart disease)
- Chronic haemolytic anemia (eg. sickle cell, thalassemia, hereditary spherocytosis)
- Storage diseases (eg. Gaucher, Niemann-Pick)
- Splenectomy
- Inability to give informed consent
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Observational Models: Cohort
- Time Perspectives: Prospective
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Presence of splenomegaly (maximal splenic cranio-caudal length) on point-of-care ultrasound
Time Frame: 12 months
|
Splenomegaly is defined as a splenic length of > 11.5 centimetres (cm) for 10-12 year-old patients, > 12 cm for 12-15 year-old patients, > 12 cm for 15-35 year-old female patients, and > 13 cm for 15-35 year-old male patients.
|
12 months
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
April 1, 2016
Primary Completion (Actual)
October 4, 2020
Study Completion (Actual)
October 4, 2020
Study Registration Dates
First Submitted
May 31, 2015
First Submitted That Met QC Criteria
June 3, 2015
First Posted (Estimate)
June 4, 2015
Study Record Updates
Last Update Posted (Actual)
October 6, 2020
Last Update Submitted That Met QC Criteria
October 4, 2020
Last Verified
October 1, 2020
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
- Pathologic Processes
- Virus Diseases
- Immune System Diseases
- Lymphoproliferative Disorders
- Lymphatic Diseases
- Immunoproliferative Disorders
- Disease Attributes
- Hematologic Diseases
- DNA Virus Infections
- Pathological Conditions, Anatomical
- Leukocyte Disorders
- Epstein-Barr Virus Infections
- Herpesviridae Infections
- Hypertrophy
- Emergencies
- Infections
- Communicable Diseases
- Splenomegaly
- Infectious Mononucleosis
Other Study ID Numbers
- POCUSIM01
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Undecided
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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