Effects of Exercise on Cardiac Fat in Women With Obesity: a Pilot Study

Excessive cardiac fat accumulation have been recognized to be associate to increased cardiac and metabolic risk. The aim of this study the effects of exercise in cardiac fat content, cardiac function, physical fitness, and metabolic activity in obesity.

Study Overview

• Status: Completed
• Conditions: Obesity
• Intervention / Treatment: Other: Exercise Intervention

Detailed Description

Excessive cardiac fat accumulation have been recognized to be associate to increased cardiac and metabolic risk. More effective treatments are needed to induce changes in cardiac fat content, body composition, and cardiac fat metabolic activity that result in a reduction in cardiovascular risk in overweight and obese population. Despite this need, little is known about which mode, frequency, and duration of exercise will allow for greater reductions in cardiac fat, improvements in body composition, restoration of a healthy cardiac fat metabolic activity, and improvement on cardiovascular risk markers. The aim of this study the effects of exercise in cardiac fat content, cardiac function, physical fitness, and metabolic activity in obesity.

• Study Type: Interventional
• Enrollment (Actual): 15
• Phase: Not Applicable

Contacts and Locations

Study Locations

• United States
  • Texas
    • Lubbock, Texas, United States, 79423
      • Kinesiology and Sport Management

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 35 years (Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: Female

Description

Inclusion Criteria:

• BMI 30-39.99
• White/Caucasian

Exclusion Criteria:

• Known health problems such as cardiovascular, pulmonary or metabolic disease will be excluded.
• Pregnant females.
• Any adults found taking medications that affect endocrine or cardiovascular function will also be excluded from the study.
• Participants that exercise more than three times per week or strength train more than twice per week.
• Individuals that have poor venous access or have expressed a fear of needles or having blood taken will also be excluded.
• Cigarette smoking (current or those who quit within the previous 6 months
• Hypertension
• Diabetics
• MRI exclusion criteria must be observed: must complete a safety checklist that is designed to identify metal in your body that could pose a hazard during scanning. Some forms of metal are acceptable (e.g., dental fillings after 1970). Tattoos are generally not exclusionary, unless they have been inked with metallic dyes. All metal must be removed from your body. All female subjects, prior to scanning, are required to complete a pregnancy test. Must NOT be claustrophobic or have a history of claustrophobia

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Exercise Intervention; Hight intensity resistance training group	Other: Exercise Intervention; The intervention will consist of 3 weeks of whole body circuit training (resistance training) where participants in the intervention group will perform 7 different exercises. The circuit will consist of 10 repetitions per exercise of 7 exercises: leg press, bent-over row, bench press, squats, dumbbell jump squats with raises, dead-lifts and weighted abdominal crunches, with approximately 30 sec of rest in between each exercise (based on the estimated time needed to move from one position to the next). Each participant will move through the circuit 3 times, with 2 to 3 minutes of rest between each round. Intensity will be 6-7 of RPE at the first set, and 9-10 at the third set.
No Intervention: Control; No-exercise control group

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Changes in Cardiac fat volumes	Cardiac fat volumes will be assessed by means of Magnetic Resonance Imaging	2 assessment points: at baseline and week 4

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Changes in Vascular function	Vascular function will be assessed by means of Arterial Tonometry	2 assessment points: at baseline and week 4
Changes in Cardiorespiratory Function	Cardiorespiratory Function will be assessed on a treadmill test with a 12-lead EKG. Protocol: Modified Bruce (A baseline stage will be added)	2 assessment points: at baseline and week 4
Changes in Muscular Strength	Muscular Strength in upper and lower extremities will be assessed by 1 repetition maximum (1RM) test on Bench Press and Leg Press	2 assessment points: at baseline and week 4
Changes in Body Composition	Body Composition will be assessed using Dual-energy x-ray absorptiometry	2 assessment points: at baseline and week 4
Changes in Diet	Diet will be assessed using the ASA24h recall (http://epi.grants.cancer.gov/asa24/)	5 assessment points: baseline, week 1, 2, 3, and 4
Changes in Spontaneous Physical Activity	Spontaneous Physical Activity will be assessed using accelerometers Actical.	Baseline and week 4
Changes in Oxidative stress markers	Blood will be collected and processed in order to assess oxidative stress markers	5 assessment points: pre-post during session 1, pre-post during session 9, and pre week 4.

Collaborators and Investigators

• Sponsor: Texas Tech University
• Investigators: Principal Investigator: Maria Fernandez del Valle, PhD, Texas Tech University

Study record dates

Study Major Dates

• Study Start: October 1, 2015
• Primary Completion (Actual): May 1, 2016
• Study Completion (Actual): May 1, 2016

Study Registration Dates

• First Submitted: October 14, 2015
• First Submitted That Met QC Criteria: October 27, 2015
• First Posted (Estimate): October 28, 2015

Study Record Updates

• Last Update Posted (Estimate): May 11, 2016
• Last Update Submitted That Met QC Criteria: May 9, 2016
• Last Verified: September 1, 2015

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Overnutrition; Nutrition Disorders; Overweight; Body Weight; Obesity
• Other Study ID Numbers: 504792C