Study on the Antiaging Effect of Chinese Herb Drink

The purpose of the current study was to check the physiological improvement of SWT on liver and skin and also the antioxidation in healthy adults.

Study Overview

• Status: Completed
• Conditions: Gynecological Disorders
• Intervention / Treatment: Other: Si-Wu-Tang (SWT); Other: placebo

Detailed Description

Background: Si-Wu-Tang (SWT) is a well-known traditional Chinese medicine (TCM) and widely used for treating various gynecological disorders. The purpose of the current study was to check the physiological improvement of SWT on liver and skin and also the antioxidation in healthy adults.

Methods: Sixty healthy voluntary subjects were recruited and assigned into two groups, who drank 125 mL of placebo (n=30) or SWT (n=30) for 6 continuous days per month during the following 6 months and vice versa with one month of washout period in between. During the initial, 3rd, 6th, 10th, and 13th months anthropometric measurements were performed as well as fasting blood samples were drawn for various biochemical assays. Abdominal ultrasonic and skin examination were performed at the initial, 6th and 13th months.

• Study Type: Interventional
• Enrollment (Actual): 60
• Phase: Not Applicable

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 20 years to 80 years (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• healthy adults

Exclusion Criteria:

• exclusion criteria were history of smoking, alcoholism
• pregnant or lactating women,
• chronic diseases, hepatic or renal dysfunction.

Study Plan

How is the study designed?

Design Details

• Allocation: Randomized
• Interventional Model: Crossover Assignment
• Masking: Double

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Si-Wu-Tang (SWT); Subjects are recommended to drink 125 mL of SWT (n=30) for 6 continuous days per month during the following 6 months and vice versa with one month of washout period in between.	Other: Si-Wu-Tang (SWT); The purpose of the current study was to check the physiological improvement of SWT on liver and skin and also the antioxidation in healthy adults.; Other Names: Si-Wu-Tang (SWT) is a Traditional Chinese Medicine formula; Other: placebo; The purpose of the current study was to check the physiological improvement of placebo on liver and skin and also the antioxidation in healthy adults.
Placebo Comparator: placebo; Subjects are recommended to drink 125 mL of Placebo (n=30) for 6 continuous days per month during the following 6 months and vice versa with one month of washout period in between.	Other: Si-Wu-Tang (SWT); The purpose of the current study was to check the physiological improvement of SWT on liver and skin and also the antioxidation in healthy adults.; Other Names: Si-Wu-Tang (SWT) is a Traditional Chinese Medicine formula; Other: placebo; The purpose of the current study was to check the physiological improvement of placebo on liver and skin and also the antioxidation in healthy adults.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Total thiobarbituric acid reactive substances (TBARS)	6 months

Secondary Outcome Measures

Outcome Measure	Time Frame
Glutathione content (GSH)	6 months
Total antioxidant capacity (TEAC)activities.	6 months
Superoxide dismutase (SOD) activity	6 months
GPx and glutathione reductase (GR) activity	6 months
Catalase	6 months
Glutamic oxaloacetic transaminase (GOT)	6 months
Glutamic pyruvic transaminase (GPT)	6 months

Other Outcome Measures

Outcome Measure	Time Frame
Skin sebum content	6 months
Skin hydration	6 months
Skin surface water loss	6 months
Skin melanin index	6 months
Skin elasticity	6 months

Collaborators and Investigators

• Sponsor: Chung Shan Medical University
• Investigators: Study Chair: Chin-Kun Wang, Chung Shan Medical University

Study record dates

Study Major Dates

• Study Start: April 1, 2008
• Primary Completion (Actual): April 1, 2009
• Study Completion (Actual): April 1, 2009

Study Registration Dates

• First Submitted: December 8, 2015
• First Submitted That Met QC Criteria: December 15, 2015
• First Posted (Estimate): December 18, 2015

Study Record Updates

• Last Update Posted (Estimate): December 18, 2015
• Last Update Submitted That Met QC Criteria: December 15, 2015
• Last Verified: December 1, 2015

More Information

Terms related to this study

• Keywords: skin; liver; anthropometric measurements; Si Wu Tang; antioxidation
• Other Study ID Numbers: CS08008