Rapid and Easy Evaluation of Cardiac Systolic Function by Means of Mitral Valve Movements in the Emergency Department

Left ventricular ejection fraction (LVEF) is a parameter that should be evaluated rapidly to the patients, admitted to the emergency department with shortness of breath. The investigators aimed to investigate correlation between LVEF and 4 different mitral valve movements which alternate to the classical LVEF assessing methods and evaluate these methods can be used or not in the emergency department.

Study Overview

• Status: Completed
• Conditions: Heart; Disease, Mitral(Valve)
• Intervention / Treatment: Other: dyspneic patients

Detailed Description

A prospective observational study was conducted in an acutely dyspneic patients with receiving echocardiagraphy by the chief physicians. Measurements were performed before echocardiography lab by the physician who conducted the survey in the emergency department. In parasternal long axis view mitral valve E-Point Septal Separation (EPSS) M-Mod measurements and mitral valve anterior leaflet and septal distance (P-ALSS) B-Mod measurements and in apical four chamber view mitral valve anterior leaflet and septal distance (A-ALSS) B-Mod measurements and distance between mitral valve anterior and posterior leaflets (MVLS) B-Mod measurements were acquired as the minimum distance in diastole. LVEF of patients were measured by cardiologist. Correlation of the all values between LVEF and sensitivity, specificity, and likelihood probabilities were calculated.

• Study Type: Observational
• Enrollment (Actual): 113

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (ADULT, OLDER_ADULT)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

an acutely dyspneic patients with receiving echocardigraphy by the chief physicians in the emergency department

Description

Inclusion Criteria:

• older than 18 years
• nontraumatic acute dyspneic patients

Exclusion Criteria:

• sigmoid septum
• septal hypertrophia
• mitral stenosis
• mitral valve prothesis
• aortic regurgitation
• regional wall motion defect

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
measuring ejection fraction; ejection fraction in an acute dyspneic patients	Other: dyspneic patients; measuring mitral valve and septal distance in acute dyspneic patients for estimating left ventricular ejection fraction

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Dyspneic patients were evaluated for their left ventricular ejection fraction by new methods with using transthoracic echocardiography.	New methods are described: First measurement is distance between mitral valve anterior leaflet and septum in early diastole in the parasternal long axis view m-mode in millimeter.second measurement is distance between mitral valve anterior leaflet and septum in early diastole in the parasternal long axis view b-mode in millimeter. third is the distance between mitral valve anterior leaflet and septum in the apical four chamber view b-mode in millimeter. forth is the distance between mitral valve anterior and posterior leaflet in apical four chamber b-mode in millimeter.	up to 2 hours after admitting to the emergency department

Collaborators and Investigators

• Sponsor: Bozyaka Training and Research Hospital
• Investigators: Principal Investigator: neslihan siliv, ızmır bozyaka traınıng and research hospital

Publications and helpful links

General Publications

• Secko MA, Lazar JM, Salciccioli LA, Stone MB. Can junior emergency physicians use E-point septal separation to accurately estimate left ventricular function in acutely dyspneic patients? Acad Emerg Med. 2011 Nov;18(11):1223-6. doi: 10.1111/j.1553-2712.2011.01196.x. Epub 2011 Nov 1.
• Weekes AJ, Reddy A, Lewis MR, Norton HJ. E-point septal separation compared to fractional shortening measurements of systolic function in emergency department patients: prospective randomized study. J Ultrasound Med. 2012 Dec;31(12):1891-7. doi: 10.7863/jum.2012.31.12.1891.
• McKaigney CJ, Krantz MJ, La Rocque CL, Hurst ND, Buchanan MS, Kendall JL. E-point septal separation: a bedside tool for emergency physician assessment of left ventricular ejection fraction. Am J Emerg Med. 2014 Jun;32(6):493-7. doi: 10.1016/j.ajem.2014.01.045. Epub 2014 Feb 3.

Study record dates

Study Major Dates

• Study Start: August 1, 2015
• Primary Completion (ACTUAL): September 1, 2015
• Study Completion (ACTUAL): October 1, 2015

Study Registration Dates

• First Submitted: December 22, 2015
• First Submitted That Met QC Criteria: January 14, 2016
• First Posted (ESTIMATE): January 18, 2016

Study Record Updates

• Last Update Posted (ESTIMATE): February 9, 2016
• Last Update Submitted That Met QC Criteria: February 7, 2016
• Last Verified: January 1, 2016

More Information

Terms related to this study

• Keywords: Ejection fraction; mitral valve; e-point septal separation
• Additional Relevant MeSH Terms: Pathologic Processes; Disease Attributes; Emergencies
• Other Study ID Numbers: 06072015

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO