PAthwAy of Dyspneic patIent in Emergency (PArADIsE) (PArADIsE)

PAthwAy of Dyspneic patIent in Emergency

This is an observational retrospective single-center study (CHRU of Nancy) in patients cared for acute dyspnea by a medical team of the emergencies of the CHRU of Nancy.

The main purpose of the study is to evaluate the outcome of patients cared for acute dyspnea by a medical team of emergencies of CHRU of Nancy.

Study Overview

• Status: Recruiting
• Conditions: Acute Disease; Dyspnea; Cardiac

Detailed Description

This observational retrospective single-center study will be conducted using data from medical records, acquired as part of usual care, patients cared for acute dyspnea in the last 5 years (from the date of authorization of data processing). About 4,000 patients will be affected, including more than 800 patients with acute heart failure.

• Study Type: Observational
• Enrollment (Anticipated): 24000

Contacts and Locations

• Study Contact: Name: Tahar CHOUIHED, MD, PhD; Phone Number: + 33 3 83 15 73 88; Email: t.chouihed@chru-nancy.fr
• Study Contact Backup: Name: Nicolas GIRERD, MD, PhD; Phone Number: +33383157322; Email: n.girerd@chru-nancy.fr

Study Locations

• France
  • Nancy, France, 54000
    • Recruiting
    • CHRU Nancy - Service des Urgences
    • Contact: Tahar CHOUIHED, MD; Phone Number: +33 3 83 85 14 96; Email: t.chouihed@chru-nancy.fr

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

Patients with acute dyspnea cared by a medical team of emergencies of CHRU Nancy in the last 5 years.

Description

Inclusion Criteria:

• Man or women ≥ 18 years
• Patients with acute dyspnea cared by a medical team of the emergencies of CHRU of Nancy.

Exclusion Criteria:

• Cardiorespiratory arrest before the care by a medical team of the emergencies of the CHRU of Nancy.

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort

Patients with acute dyspnea; Patients with acute dyspnea treated by a medical team of emergencies of CHRU of Nancy. All patients admitted to the emergencies in the last 5 years matching the inclusion criteria will be evaluated. About 4,000 patients will be affected, including more than 800 patients with acute heart failure. (Figures based on export of ICD X codes (R06.0: Dyspnea) of patients cared in extra-hospital for acute dyspnea (diagnosis Dyspnea + Heart Failure) over the last 5 years).

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
All cause in-hospital mortality	in the last 5 years

Secondary Outcome Measures

Outcome Measure	Time Frame
Demographic and clinical data of patients cared by a medical team of emergencies	in the last 5 years
Duration of total hospitalization (including emergency stay and conventional hospitalization)	in the last 5 years
The main diagnosis of the initial hospitalization	in the last 5 years
Rate of Brain Natriuretic Peptide (BNP)	in the last 5 years
Administration of non-invasive ventilation and / or diuretics and / or nitrates	in the last 5 years
Administration time of non-invasive ventilation and / or diuretics and / or nitrates	in the last 5 years
Service type admitting the patient after the emergency care (intensive care, cardiology, intensive care cardiology, other ...)	in the last 5 years
Admission time in a service after the emergency care	in the last 5 years
Mortality and re-hospitalization of included patients	in the last 5 years

Collaborators and Investigators

• Sponsor: CHOUIHED Tahar
• Collaborators: Central Hospital, Nancy, France
• Investigators: Principal Investigator: Nicolas GIRERD, MD, Central Hospital, Nancy, France; Principal Investigator: Tahar CHOUIHED, MD, PhD, Central Hospital, Nancy, France

Publications and helpful links

General Publications

• Chouihed T, Bassand A, Duarte K, Jaeger D, Roth Y, Giacomin G, Delaruelle A, Duchanois C, Bannay A, Kobayashi M, Rossignol P, Girerd N. Head-to-head comparison of diagnostic scores for acute heart failure in the emergency department: results from the PARADISE cohort. Intern Emerg Med. 2022 Jun;17(4):1155-1163. doi: 10.1007/s11739-021-02879-6. Epub 2021 Nov 17.
• Chouihed T, Buessler A, Bassand A, Jaeger D, Virion JM, Nace L, Barbe F, Salignac S, Rossignol P, Zannad F, Girerd N. Hyponatraemia, hyperglycaemia and worsening renal function at first blood sample on emergency department admission as predictors of in-hospital death in patients with dyspnoea with suspected acute heart failure: retrospective observational analysis of the PARADISE cohort. BMJ Open. 2018 Mar 30;8(3):e019557. doi: 10.1136/bmjopen-2017-019557.

Study record dates

Study Major Dates

• Study Start (Actual): March 1, 2016
• Primary Completion (Actual): December 1, 2018
• Study Completion (Anticipated): October 25, 2025

Study Registration Dates

• First Submitted: June 6, 2016
• First Submitted That Met QC Criteria: June 10, 2016
• First Posted (Estimate): June 15, 2016

Study Record Updates

• Last Update Posted (Actual): April 18, 2023
• Last Update Submitted That Met QC Criteria: April 14, 2023
• Last Verified: April 1, 2023

More Information

Terms related to this study

• Keywords: emergency; acute heart failure; acute dyspnea
• Additional Relevant MeSH Terms: Pathologic Processes; Respiratory Tract Diseases; Respiration Disorders; Disease Attributes; Signs and Symptoms, Respiratory; Emergencies; Acute Disease; Dyspnea
• Other Study ID Numbers: R2016-08

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO