Staphylokinase and ABO Group Phenotype: New Players in Staphylococcus Aureus Implant-associated Infections Development

Staphylokinase and ABO Group Phenotype: New Players in Staphylococcus Aureus Implant-associated Infections Development

Sponsors

Lead sponsor: Nantes University Hospital

Source Nantes University Hospital
Brief Summary

The purpose of this study is to identify bacterial and/or clinical features involved in the pathogenesis of Staphylococcus aureus implant-associated infections (IAI). Materials & methods: In total, 57 IAI S. aureus and 31 nasal carriage (NC) S. aureus isolates were studied. Staphylococcus aureus genetic background was obtained by microarray analysis. Multilocus sequence typing was performed to determine clonal complexes (CC). Biofilm production was investigated by resazurin and crystal violet methods

Overall Status Completed
Start Date February 2012
Completion Date December 2013
Primary Completion Date September 2012
Study Type Observational
Primary Outcome
Measure Time Frame
biofilm production measurement in the two groups september 2012
Clonal complexes distribution september 2012
IAI and NC nasal carriage isolates genetic background september 2012
Secondary Outcome
Measure Time Frame
biofilm production correlation with genotype december 2013
Correlation between Clonal Complexes distribution , genotype and clinical parameters december 2013
Association of ABO group phenotype and IAI S. aureus genotype december 2013
Enrollment 88
Condition
Intervention

Intervention type: Other

Intervention name: IAI infection

Arm group label: IAI patients group

Intervention type: Other

Intervention name: Staphylococcus aureus nasal carriage infection

Arm group label: control group

Eligibility

Sampling method: Non-Probability Sample

Criteria:

Inclusion Criteria:

- infected patients with S. Aureus IAI infection

- noninfected patients screened for S. aureus nasal colonization at the orthopedic consultation ward

Exclusion Criteria:

- minor

Gender: All

Minimum age: N/A

Maximum age: N/A

Healthy volunteers: No

Verification Date

June 2016

Responsible Party

Responsible party type: Sponsor

Keywords
Has Expanded Access No
Condition Browse
Arm Group

Arm group label: IAI patients group

Description: patients with Staphylococcus aureus of implant-associated infections

Arm group label: control group

Description: patients with Staphylococcus aureus nasal carriage

Patient Data No
Study Design Info

Observational model: Case Control

Time perspective: Retrospective

Source: ClinicalTrials.gov