Eye Movements and Visuo-spatial Perception

Coupling Between Adaptation of Saccadic Eye Movements and Visuo-spatial Perception and Attention Processes: a Behavioural Study in Humans.

This research aims to highlight the key roles of the cerebellar and cortical fronto-parietal networks in the coupling of eye movements with visual perception and visuo-spatial attention.

Study Overview

• Status: Completed
• Conditions: Cerebellum Disease
• Intervention / Treatment: Behavioral: Forward adaptation of reactive saccades; Behavioral: Backward adaptation of reactive saccades; Behavioral: Execution of reactive saccades; Behavioral: Generation of reactive saccades

Detailed Description

The first axe of this research focuses on the role of the cerebellum which has a major contribution to sensorimotor adaptation and more precisely in saccadic adaptation but the nature of this contribution is still debated. A classical assumption stipulates cerebellum has an exclusive action on saccadic burst generator in the brainstem whereas recent data increasingly support the view that cerebellum could also modulates cerebral cortex through a cerebello-thalamo-cortical pathway. On the other hand, several studies have shown that modification of saccade amplitude by saccadic adaptation leads to a distortion of the visual localization of briefly flashed spatial probes but no study to date has tested, the contribution of the cerebellum in these adaptation-induced mislocalizations. The main objective of this axe is to define the role of the cerebellum not only in saccadic adaptation, but also in mislocalizations which occur after adaptation. Moreover, in testing this assumption, arguments in favour -or in disfavor- of the action of the cerebellum on cortical stages dedicated to visuo-spatial perceptual processing will be provided. Besides, variability of cerebellar lesion (or cerebellar dysfunction) location in patients can lead to different pattern in saccadic adaptation and localization task performances. Identification of dissociations between these two abilities in some patients will define more precisely the role of the cerebellum in the coupling between saccadic adaptation and visuo spatial perception as an oculomotor plasticity territory and / or as a territory underlying the error signal coding generating this type of plasticity.

This second axe of this research aims to apply basic findings in healthy subject on the coupling between oculomotor plasticity and spatial attention to patients with parietal lesion, in order to evaluate a rehabilitation procedure for neglect patients. Habchi and colleagues showed that the adaptation of reactive saccades in the left hemifield has a boosting effect on attentional performance in the same hemifield. The coupling between these two mechanisms highlighted in healthy subjects can be used as fundamentals in the elaboration of a rehabilitation procedure for attentional disorders in the neglect syndrome. This syndrome is mainly observed after cerebral lesions in the right hemisphere, and is characterized by very disabling cognitive disorders such as an alteration of the spatial representation of left hemi-space and/or left hemi-body. stimulation of sensorimotor plasticity thanks to prismatic adaptation could be used as a rehabilitation procedure for this syndrome. Being another efficient way to stimulate sensorimotor plasticity, the equip believe that saccadic adaptation can also be used as a rehabilitation procedure for neglect patients. Moreover, due to its tight coupling with visual attention, the benefits of saccadic adaptation could be even stronger and longer lasting than the visuo-manual plasticity induced by prismatic adaptation.

• Study Type: Interventional
• Enrollment (Actual): 24
• Phase: Not Applicable

Contacts and Locations

Study Locations

• France
  • Bron, France, 69500
    • Hospices Civils de Lyon

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 80 years (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Age : from 18 to 80 ans included
• Visual acuity monocularly at distance and near corrected : > 5/10
• Possible understanding of experimental guidelines
• Possible respect for sustained seated position
• Subject covered by social security
• Agreement of the subject

Inclusion Criteria, specific to Axe 1:

• Cerebellar patients - Cerebellar degenerative disease (group A) or stroke (group B, délai depuis l'AVC : delay from the stroke : at least 1 month)

  • Scanner or MRI showing diffuse atrophy (group A) or focal cerebellar lesion (group B)

• Healthy subjects

  • Absence of known ophtalmological or neurological pathology

Inclusion Criteria, specific to Axe 2:

• Stroke patients - ischemic or hemorrhagic stroke

  • Encephalic MRI or CT scan showing an unique lesion
  • Minimal delay of one year after the stroke

Exclusion Criteria:

• Visual acuity monocularly < 5/10
• Language disorder restricting oral and reading comprehension of the study
• Severe disability limiting the maintenance of sitting position and concentration capacities for a period of 30 minutes consecutive
• Poor French language skills
• Non-stabilized medical condition
• Psychotropic medication intake
• Pregnant and / or nursing women
• Subject under guardianship or curatorship
• Subject frequently in healthcare or social care for purposes other than research
• Subject deprived of liberty by a judicial or administrative decision

Exclusion Criteria, specific to Axe 1:

• Cerebellar patients

- Disorders prohibiting the correct performance of the task (tremor, ocular instability)

Exclusion Criteria, specific to Axe 2:

• Stroke patients

• Hemianopsia homonima lateral
• Neurological degenerative disease

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: Randomized
• Interventional Model: Factorial Assignment
• Masking: Single

Number of Arms

5

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: FORWARD (Axe 1)	Behavioral: Forward adaptation of reactive saccades; Protocol of reactive saccade where the target is displaced in the same direction as the saccade in order to induce an adaptive increase of saccade amplitude ('forward adaptation')
Experimental: BACKWARD (Axe 1)	Behavioral: Backward adaptation of reactive saccades; Protocol of reactive saccade where the target is displaced in a direction opposite to the saccade in order to induce an adaptive decrease of saccade amplitude ('backward adaptation')
Experimental: CONTROL (Axe 1)	Behavioral: Execution of reactive saccades; Control protocol of reactive saccade with no displacement of the saccadic target (controlling for non specific factors possibly involved in forward and backward adaptation conditions)
Experimental: ADAPTATION (Axe 2)	Behavioral: Backward adaptation of reactive saccades; Protocol of reactive saccade where the target is displaced in a direction opposite to the saccade in order to induce an adaptive decrease of saccade amplitude ('backward adaptation')
Experimental: CONTROL (Axe 2)	Behavioral: Generation of reactive saccades; Control protocol of reactive saccade with no displacement of the saccadic target (controlling for non specific factors possibly involved in adaptation condition)

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Saccadic adaptation efficiency	〖Adaptation〗_rate= (〖Amplitude 〗_post-〖Amplitude 〗_pre)/〖Amplitude 〗_pre	At time of each experimental session, up to 2 months, since first experimental visit until last visit

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Evolution of localization-task performances	〖Improvement〗_performances= (〖Mislocalization 〗_post-〖Mislocalization 〗_pre)/〖Mislocalization 〗_pre	At time of each experimental session, up to 2 months, since first experimental visit until last visit
Evolution of attentional performances assessed by neuropsychological tests of neglect	〖Improvement〗_performances= (〖Score 〗_post-〖Score〗_pre)/〖Score〗_pre	At time of each experimental session, up to 2 months, since first experimental visit until last visit

Collaborators and Investigators

• Sponsor: Hospices Civils de Lyon
• Investigators: Principal Investigator: Caroline Tilikete, MD, Hospices Civils de Lyon

Study record dates

Study Major Dates

• Study Start (Actual): September 26, 2018
• Primary Completion (Actual): October 2, 2020
• Study Completion (Actual): October 2, 2020

Study Registration Dates

• First Submitted: March 29, 2017
• First Submitted That Met QC Criteria: April 7, 2017
• First Posted (Actual): April 13, 2017

Study Record Updates

• Last Update Posted (Actual): April 21, 2022
• Last Update Submitted That Met QC Criteria: April 20, 2022
• Last Verified: April 1, 2022

More Information

Terms related to this study

• Keywords: cerebellar lesion; saccadic adaptation; spatial localization; visuo spatial perception; eye movements
• Additional Relevant MeSH Terms: Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Cerebellar Diseases
• Other Study ID Numbers: 69HCL17_0109; 2017-A00942-51 (Other Identifier: ID-RCB)

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: No

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No