Hybrid Exercise Training for Weight Loss (DoIT)

October 25, 2021 updated by: Ioannis G. Fatouros, University of Thessaly

The Effects of a Novel Hybrid Exercise Training Program on Body Composition, Body Weight and Energy Balance in Sedentary Overweight/Obese Women

In this study the investigators utilized a novel hybrid HIIT (high intensity interval training) exercise training approach, the Hybrid Interval Training (DoIT) workout that combines interval training, resistance exercise training and functional training in order to test the hypothesis that DoIT will be able to: i) reduce body mass, ii) improve body composition and iii) alter energy balance, of previously inactive, overweight/obese women.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

In a controlled randomized, two-group, repeated measures design, 65 healthy, sedentary, premenopausal overweight or obese women were randomly assigned to one of three groups: (a) a control group (C, N=21) that participated only in measurements, (b) a training group (TR, N=14) that participated in a supervised 40-week DoIT workout exercise training program and (c) a training-detraining group (TRD, N=14). During the first 20 weeks, TR and TRD followed exactly the same training protocol. At the end of this period, TR continued training for 20 more weeks whereas TRD terminated training for 20 weeks (detraining). Anthropometric, metabolic, daily nutritional intake, habitual physical activity and performance measurements were performed in all groups at baseline, at 20 weeks and 40 weeks.

Study Type

Interventional

Enrollment (Actual)

49

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Greece
    • Karies
      • Trikala, Karies, Greece, 42100
        • Exercise Biochemistry Laboratory, School of Physical Education & Sports Sciences, University of Thessaly

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

30 years to 45 years (Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

Female

Description

Inclusion Criteria:

  • (a) were sedentary (<7,500 steps/day; VO2max <30 ml/kg/min), b) premenopausal women aged 30-45 years, c) were overweight or obese class 1 (BMI=25-34.9 kg/m2), d) were non-smokers for ≥6 months before the study, e) not following a diet intervention or using nutritional supplements/medications before (≥6 months) and during the study, f) had no weight loss greater >10% of body mass ≤6 months before the study, g) participated in ≥80% of total exercise sessions, and h) had no symptoms of depression.

Exclusion Criteria:

  • a) a recent febrile illness, b) history of muscle lesion, c) lower limb trauma, d) signs, symptoms or diagnosis of serious health complications or physical disability or other medical condition compromising safe participation in exercise training.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Basic Science
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Control
Participated only in measurements at baseline, at 20 weeks and at 40 weeks.
Behavioral: Control - No training
No training was performed during a 40-week period. Participation only in measurements.
Experimental: Training
Participated in a supervised 40-week DoIT workout exercise training program and in measurements at baseline, at 20 weeks and at 40 weeks.
Behavioral: DoIT workout
A hybrid small-group (5-10 women/session) training modality, that combines interval training, resistance exercise and functional training and performed according to a periodized model of exercise prescription as an alternative approach for weight management. FFIT was performed 3 times/week with 48 hours recovery between sessions for 40 weeks.
Experimental: Training-Detraining
Participated in a supervised 20-week DoIT workout exercise training program and then entered a 20-week detraining period. They also participated in measurements at baseline, at 20 weeks and at 40 weeks.
Behavioral: DoIT workout - Detraining
A hybrid small-group (5-10 women/session) training modality, that combines interval training, resistance exercise and functional training, performed according to a periodized model of exercise prescription for a 20-week period (3 times/week). Immediately after a 20-week detraining period (no training was performed) was followed.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Change in body mass
Time Frame: At baseline, at 20 weeks and at 40 weeks.
At baseline, at 20 weeks and at 40 weeks.
Change in body mass index
Time Frame: At baseline, at 20 weeks and at 40 weeks.
At baseline, at 20 weeks and at 40 weeks.
Change in waist circumference
Time Frame: At baseline, at 20 weeks and at 40 weeks.
At baseline, at 20 weeks and at 40 weeks.
Change in hip circumference
Time Frame: At baseline, at 20 weeks and at 40 weeks.
At baseline, at 20 weeks and at 40 weeks.
Change in waist-to-hip ratio
Time Frame: At baseline, at 20 weeks and at 40 weeks.
At baseline, at 20 weeks and at 40 weeks.
Change in body fat.
Time Frame: At baseline, at 20 weeks and at 40 weeks.
Body fat assessed by whole-body dual-energy X-ray absorptiometry (DXA).
At baseline, at 20 weeks and at 40 weeks.
Change in fat mass
Time Frame: At baseline, at 20 weeks and at 40 weeks.
Fat mass assessed by whole-body dual-energy X-ray absorptiometry (DXA).
At baseline, at 20 weeks and at 40 weeks.
Change in fat-free mass
Time Frame: At baseline, at 20 weeks and at 40 weeks.
Fat-free mass assessed by whole-body dual-energy X-ray absorptiometry (DXA).
At baseline, at 20 weeks and at 40 weeks.
Change in resting metabolic rate
Time Frame: At baseline, at 20 weeks and at 40 weeks.
Measured using a portable open-circuit indirect calorimeter with a ventilated hood system.
At baseline, at 20 weeks and at 40 weeks.
Change in exercise-induced caloric expenditure.
Time Frame: At baseline, at 20 weeks and at 40 weeks.
Measured using a portable indirect calorimetry system
At baseline, at 20 weeks and at 40 weeks.

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Change in maximal strength (1RM)
Time Frame: At baseline, at 20 weeks and at 40 weeks.
Measured bilaterally on a horizontal leg press.
At baseline, at 20 weeks and at 40 weeks.
Change in maximal oxygen consumption (VO2max)
Time Frame: At baseline, at 20 weeks and at 40 weeks.
Assessed by a portable open-circuit spirometry system.
At baseline, at 20 weeks and at 40 weeks.
Change in blood lactate concentration
Time Frame: Pre-exercise, during the exercise and post-exercise at baseline, at 20 weeks and at 40 weeks.
Pre-exercise, during the exercise and post-exercise at baseline, at 20 weeks and at 40 weeks.
Change in habitual physical activity
Time Frame: At baseline, at 20 weeks and at 40 weeks.
Seven-day habitual physical activity was assessed by accelerometry
At baseline, at 20 weeks and at 40 weeks.
Change in dietary intake
Time Frame: At baseline, at 20 weeks and at 40 weeks.
Assessed using 7-day diet recalls
At baseline, at 20 weeks and at 40 weeks.

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University of Thessaly

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

July 1, 2015

Primary Completion (Actual)

July 1, 2016

Study Completion (Actual)

April 1, 2017

Study Registration Dates

First Submitted

April 26, 2017

First Submitted That Met QC Criteria

April 26, 2017

First Posted (Actual)

May 1, 2017

Study Record Updates

Last Update Posted (Actual)

October 28, 2021

Last Update Submitted That Met QC Criteria

October 25, 2021

Last Verified

October 1, 2021

More Information

Terms related to this study

Other Study ID Numbers

  • DoIT-UTH

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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