Aerobic Exercise in Boys With Duchenne Muscular Dystrophy (DMD)

January 31, 2019 updated by: Aaron Zelikovich, Ann & Robert H Lurie Children's Hospital of Chicago

Evaluating the Impact of Aerobic Exercise in Boys With Duchenne Muscular Dystrophy (DMD)

This research study wants to learn more about Duchenne Muscular Dystrophy (DMD) and exercise. Today it is unknown how exercising impacts boys with DMD. The investigators believe that increasing activity and aerobic exercise may help with heart, lung, and muscle function. The investigators are hoping to compare physical strength and blood samples of boys with DMD to see if there are any differences between kids who exercised more as a child versus those who didn't.

Study Overview

Status

Completed

Conditions

Detailed Description

Recently, the American Academy of Neurology released new guidelines for children with Duchenne Muscular Dystrophy (DMD) with an updated recommendation to include moderate aerobic exercise. Historically, children with DMD were advised to not exercise as it was thought to accelerate muscle loss. Today, there is new data suggesting that moderate aerobic exercise that does not strain muscle may be beneficial and improve a child's quality of life with regard to heart disease, fatigue, and other factors of overall health. Although it is expected that children who exercise will experience health benefits, there is no scientific evidence indicating a positive or negative effect in a DMD population.

This study is trying to understand the role of aerobic exercise in boys with DMD and how it may impact heart, muscle, and lung function using newly identified biomarkers. The goal is to correlate increased aerobic exercise with improved functional outcomes and changes in biomarkers.

The data collected from this study will allow future development and implementation of an innovative and disease-specific home aerobic exercise program that in the future will be recommended to families of children with DMD.

Study Type

Observational

Enrollment (Actual)

43

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United States
    • Illinois
      • Chicago, Illinois, United States, 60611
        • Ann and Robert H. Lurie Children's Hospital of Chicago

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

2 years to 17 years (Child)

Accepts Healthy Volunteers

N/A

Genders Eligible for Study

Male

Sampling Method

Probability Sample

Study Population

The target population is ambulatory and non-ambulatory boys with DMD.

Description

Inclusion Criteria:

  • Ages 2-17 years old with a confirmed diagnosis of DMD. Has an appointment in MDA clinic at the Ann & Robert H. Lurie Children's Hospital of Chicago.

Exclusion Criteria:

  • Is less than two years old and does not have a confirmed diagnosis of DMD.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Duchenne Muscular Dystrophy (DMD)
Enrolls boys with a genetically confirmed diagnosis of DMD.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
microRNA levels
Time Frame: Baseline only
Understanding if there are any differences in microRNA's in boys who are more active versus those who are not.
Baseline only

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Physical therapy assessment - 10 meter run test
Time Frame: Baseline only
Time in seconds that it takes a participant to run 10 meters.
Baseline only
Physical therapy assessment - North Star Ambulatory Assessment
Time Frame: Baseline only
Comparing a standardized test for ambulatory boys with DMD that gives a score out of 34 total points and microRNA levels.
Baseline only
Physical therapy assessment - time to standing from supine
Time Frame: Baseline only
Time in seconds that it takes a participant to stand from a supine position.
Baseline only
Cardiac Assessments: Electrocardiogram (ECG)
Time Frame: Baseline only
Comparing heart rate (BPM), PR interval (msec), QRS (msec), and QT intervals (msec) to microRNA levels.
Baseline only
Cardiac Assessments: Echocardiogram (ECHO)
Time Frame: Baseline only
Comparing ejection fraction (%) and other Left Ventricle systolic and diastolic metrics (cm) and microRNA levels.
Baseline only
Questionnaire: Pediatric Quality of Life: Neuromuscular module
Time Frame: Baseline only
To see if there is any correlation between Quality of Life scores (range from 0 to 100) and microRNA levels. Increased scores indicate a higher quality of life.
Baseline only
Questionnaire: Physical Function Survey
Time Frame: Baseline only
To see if there is any correlation between scores of functional ability (with a range from 0 to 106) and microRNA levels. Higher physical function function scores indicate increased strength.
Baseline only

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Ann & Robert H Lurie Children's Hospital of Chicago

Investigators

  • Principal Investigator: Aaron S Zelikovich, Ann and Robert H. Lurie Children's Hospital of Chicago

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

September 1, 2017

Primary Completion (Actual)

April 30, 2018

Study Completion (Actual)

September 30, 2018

Study Registration Dates

First Submitted

October 9, 2017

First Submitted That Met QC Criteria

October 22, 2017

First Posted (Actual)

October 24, 2017

Study Record Updates

Last Update Posted (Actual)

February 4, 2019

Last Update Submitted That Met QC Criteria

January 31, 2019

Last Verified

January 1, 2019

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • Aerobic Exercise DMD

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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