Study of the Aorta Adaptations to Exercise in Triathletes During Sports Season (CoATri) (CoATri)

Study of the Remodeling of the Ascending Aorta During the Sports Season in Long Distance Triathletes Versus Controls

Regular sustained physical activity creates a cardiac remodelling : it is athlete's heart. In our preliminary work published in 2016, the investigators demonstrated in a small population of triathletes that there is also a vascular remodelling named athlete's artery. Moreover, the investigators know that left ventricle and aorta behave together like a couple. So they want to study by Cardiovascular Magnetic Resonance Imaging the impact of triathlon on the cardiac AND aortic remodelling.

Study Overview

• Status: Completed
• Conditions: Athletes; Vascular Remodeling; Stiffness, Aortic; Magnetic Resonance Imaging, Functional; Cardiac Remodeling, Ventricular
• Intervention / Treatment: Device: Cardiac MRI; Device: Applanation tonometry

• Study Type: Interventional
• Enrollment (Actual): 63
• Phase: Not Applicable

Contacts and Locations

Study Locations

• France
  • Nancy, France, 54000
    • Central Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 39 years (ADULT)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: Male

Description

Inclusion Criteria:

• to be enrolled in a social security plan.
• to have a BMI between 18,5 and 25 kg/m²
• to have received full information on the organization of the research and having signed its informed consent

• to have carried out a clinical screening adapted to the research

  *** Triathlete group:

• to have a minimum performance level: between 2h and 2h45 on an M triathlon during the past year (provide proof),
• to participate in 2018 in a long distance triathlon, i. e. at least distance L

• to have a defined training volume: less than 8 hours per week during the winter months and between 10 and 15 hours per week in preparation of the objective

  ***Control group:

• to have no more than 150 minutes of moderate physical activity per week (footing, brisk walking, cycling, etc.).

Exclusion Criteria:

• Persons referred to in Articles L. 1121-5 to L. 1121-8 and L1122-2 of the Public Health Code
• Cardiovascular history including Ii.e. known heart rhythm disorders
• Chronic disease: diabetes, high blood pressure...
• Long-term drug therapies that may modify cardiovascular remodeling such as Conversion Enzyme Inhibitor, Angiotensin II Receptor Antagonist,
• Active smoking, even if occasional
• Contraindication to MRI

Study Plan

How is the study designed?

Design Details

• Primary Purpose: BASIC_SCIENCE
• Allocation: NON_RANDOMIZED
• Interventional Model: PARALLEL
• Masking: NONE

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
EXPERIMENTAL: Triathletes; Every triathlete will realize three cardiac MRI exams.The second of those will be done at the fitness peak, 2-3 weeks before the main objective of the sports season. Training will be increased between the study beginning and the first MRI, and the second exam. After each cardiac MRI, an applanation tonometry examination will aslo be performed.	Device: Cardiac MRI; Non injected cardiac MRI exam; Device: Applanation tonometry; Applanation tonometry and ECG
EXPERIMENTAL: Controls; Every control subject will also realize three cardiac MRI exams if possible at the same time as the triathletes.They must be not engaged in physical activity more than 150 minutes a week on average. After each cardiac MRI, an applanation tonometry examination will aslo be performed.	Device: Cardiac MRI; Non injected cardiac MRI exam; Device: Applanation tonometry; Applanation tonometry and ECG

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Aortic compliance in triathletes in mm2/mmHG	aortic compliance = pulsed pressure-to-absolute variation of aortic surface ratio	at baseline, at the fitness peak (6 to 10 months later) and at recovery (3 to 6 months after the fitness peak)

Collaborators and Investigators

• Sponsor: Central Hospital, Nancy, France
• Investigators: Principal Investigator: Damien MANDRY, MD,PhD, CHRU de Nancy; Principal Investigator: Anne-Charlotte DUPONT, MD, CHRU de Nancy

Publications and helpful links

General Publications

• Dupont AC, Poussel M, Hossu G, Marie PY, Chenuel B, Felblinger J, Mandry D. Aortic compliance variation in long male distance triathletes: A new insight into the athlete's artery? J Sci Med Sport. 2017 Jun;20(6):539-542. doi: 10.1016/j.jsams.2016.10.009. Epub 2016 Oct 29.

Study record dates

Study Major Dates

• Study Start (ACTUAL): December 1, 2017
• Primary Completion (ACTUAL): March 8, 2019
• Study Completion (ACTUAL): March 8, 2019

Study Registration Dates

• First Submitted: November 22, 2017
• First Submitted That Met QC Criteria: November 28, 2017
• First Posted (ACTUAL): November 29, 2017

Study Record Updates

• Last Update Posted (ACTUAL): February 11, 2020
• Last Update Submitted That Met QC Criteria: February 10, 2020
• Last Verified: January 1, 2019

More Information

Terms related to this study

• Keywords: CMR; Triathletes; Aortic compliance; Aortic distensibility; Ventriculo-atrial coupling
• Additional Relevant MeSH Terms: Pathologic Processes; Pathological Conditions, Anatomical; Ventricular Remodeling; Vascular Remodeling
• Other Study ID Numbers: 2017-A01872-51

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No