- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04215952
Semantic Feature Analysis Treatment for Aphasia
Optimizing and Understanding Semantic Feature Analysis Treatment for Aphasia: A Randomized Controlled Comparative Effectiveness Trial
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
This randomized comparative effectiveness trial examines whether active manipulation of a key component of semantic feature analysis (SFA) treatment for word-finding difficulty in aphasia improves outcomes. 40 study participants will be recruited and randomized to receive one of the two versions of the treatment. The total treatment time will be equated in the two conditions.
Study participants will be housed locally at the Pittsburgh site at no cost and will be eligible to receive reimbursement for travel expenses. During the five-week treatment phase of the study, participants will receive 60 hours of SFA treatment with pre- and post-treatment assessment of their ability to name pictures of treated and untreated, semantically related nouns. Other secondary outcomes, including measures of connected speech and patient-reported communication ability will also be collected. In order to address unresolved questions about the underlying cognitive and neural mechanisms of SFA, participants will also receive concurrent pre- and post-treatment assessment of automatic word processing ability using eye-tracking methods and functional magnetic resonance imaging (fMRI). Participants will also be asked to return to Pittsburgh for two days approximately 2-3 months later for follow-up language, eye-tracking, and fMRI testing.
The language testing results will be used to determine which version of SFA treatment optimizes outcomes. The eye-tracking results will be used to infer whether SFA's positive effects can be attributed to improved activation of lexical-semantic representations, improved ability to inhibit competing representations, or both. The fMRI results will be used to identify the brain networks and activation changes associated with changes in naming ability resulting from SFA. This study will provide theoretically and clinically relevant information about how aphasia treatment should be delivered and the neurocognitive mechanisms underlying its effects.
Study Type
Enrollment (Anticipated)
Phase
- Not Applicable
Contacts and Locations
Study Contact
- Name: Mary Sullivan, B.S.
- Phone Number: 412-360-6472
- Email: mary.sullivan@va.gov
Study Contact Backup
- Name: Alyssa Autenreith, M.A.
- Phone Number: 412-360-6495
- Email: alyssa.autenreith@va.gov
Study Locations
-
-
Pennsylvania
-
Pittsburgh, Pennsylvania, United States, 15240
- Recruiting
- VA Pittsburgh Healthcare System
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- 6 months post-onset of aphasia due to unilateral left-hemisphere (LH) stroke
- Independent in activities of daily living (ADLs) necessary to live in community-based housing or available caregiver to assist with ADLs
- Medically stable and able to tolerate intensive treatment schedule (e.g. no uncontrolled seizures, difficulty breathing, frequent migraines)
- English as a first language
- No participation in any other speech-language treatment during this study, including follow-up period
- Sufficient auditory comprehension abilities demonstrated during screening
- Sufficient naming impairment exhibited during screening
Exclusion Criteria:
- Right Hemisphere stroke
- Neurological disease other than stroke
- Significant psychiatric disorder
- Severe motor speech disorder
- Active substance dependence
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Quadruple
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: SFA Experimental Intervention
A modified version of Semantic Feature Analysis will be administered.
|
On each treatment trial, the clinician will show the participant with aphasia a pictured object and ask them to name it.
The clinician will then guide the participant in verbally generating semantic features for the target, using a chart that specifies five kinds of features: group, use/action, properties, location, and personal associations.
When the participant cannot generate a given feature, cueing or other assistance will be provided.
After feature generation, the clinician will ask the participant to name the picture again and provide cueing if needed.
The clinician will then review the generated features and ask the participant to name the item once more, with cueing if needed.
Finally, the clinician will ask the participant to say a sentence containing the target word and provide cueing if needed.
Treatment will then proceed to the next item.
Participants will receive approximately 20 hours of treatment on each of three 10-item lists, for a total of 60 hours of treatment.
Other Names:
|
Active Comparator: SFA Active Comparator Intervention
A standard version of Semantic Feature Analysis will be administered.
|
On each treatment trial, the clinician will show the participant with aphasia a pictured object and ask them to name it.
The clinician will then guide the participant in verbally generating semantic features for the target, using a chart that specifies five kinds of features: group, use/action, properties, location, and personal associations.
When the participant cannot generate a given feature, cueing or other assistance will be provided.
After feature generation, the clinician will ask the participant to name the picture again and provide cueing if needed.
The clinician will then review the generated features and ask the participant to name the item once more, with cueing if needed.
Finally, the clinician will ask the participant to say a sentence containing the target word and provide cueing if needed.
Treatment will then proceed to the next item.
Participants will receive approximately 20 hours of treatment on each of three 10-item lists, for a total of 60 hours of treatment.
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Confrontation Naming
Time Frame: (1) 1 week prior to intervention; (2) immediately prior to intervention; (3) 1-2 days post intervention (4) 8 to 12 weeks post intervention
|
Change in naming accuracy on 30 treated pictured object nouns and 30 untreated pictured object nouns semantically related to the treated items.
|
(1) 1 week prior to intervention; (2) immediately prior to intervention; (3) 1-2 days post intervention (4) 8 to 12 weeks post intervention
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Nicholas and Brookshire Picture Descriptions
Time Frame: (1) 1 week prior to intervention; (2) immediately prior to intervention; (3) 1-2 days post intervention (4) 8 to 12 weeks post intervention
|
Change in the number of correct information units produced during connected speech in response to the stimuli and procedures described by Nicholas and Brookshire (1993) and Brookshire & Nicholas (1994).
|
(1) 1 week prior to intervention; (2) immediately prior to intervention; (3) 1-2 days post intervention (4) 8 to 12 weeks post intervention
|
Aphasia Communication Outcome Measure (ACOM)
Time Frame: (1) 1 week prior to intervention; (2) immediately prior to intervention; (3) 1-2 days post intervention (4) 8 to 12 weeks post intervention
|
Change in ACOM T-scores derived from the scoring model described by Hula and colleagues (2015).
Higher scores on this scale indicate better self-reported communicative functioning.
The scale was constructed such that the average score is 50 and the standard deviation is 10 points.
The minimum possible score is 15 and the maximum possible score is 85.
|
(1) 1 week prior to intervention; (2) immediately prior to intervention; (3) 1-2 days post intervention (4) 8 to 12 weeks post intervention
|
Visual World Paradigm
Time Frame: (1) 1 week prior to intervention; (2) immediately prior to intervention; (3) 1-2 days post intervention (4) 8 to 12 weeks post intervention
|
Change in the mean proportions of fixations to the target and to the related competitor (compared to unrelated distractor images), averaged across trials.
|
(1) 1 week prior to intervention; (2) immediately prior to intervention; (3) 1-2 days post intervention (4) 8 to 12 weeks post intervention
|
Functional MRI
Time Frame: (1) 1 week prior to intervention; (2) immediately prior to intervention; (3) 1-2 days post intervention (4) 8 to 12 weeks post intervention
|
Changes in task-related blood oxygen level dependent (BOLD) activation, and task-related and resting state functional connectivity
|
(1) 1 week prior to intervention; (2) immediately prior to intervention; (3) 1-2 days post intervention (4) 8 to 12 weeks post intervention
|
Comprehensive Aphasia Test
Time Frame: (1) 1 week prior to intervention; (2) immediately prior to intervention; (3) 1-2 days post intervention (4) 8 to 12 weeks post intervention
|
Change in the Modality Mean T-Score computed from the following six modality subtests: Spoken Language Comprehension, Written Language Comprehension, Repetition, Naming, Reading, and Writing.
|
(1) 1 week prior to intervention; (2) immediately prior to intervention; (3) 1-2 days post intervention (4) 8 to 12 weeks post intervention
|
Philadelphia Naming Test (PNT)
Time Frame: (1) 1 week prior to intervention; (2) immediately prior to intervention; (3) 1-2 days post intervention (4) 8 to 12 weeks post intervention
|
Change in PNT score estimates derived from the item response theory model described by Fergadiotis, Kellough, & Hula (2015).
Scores will be scaled such that the expected average score among persons with aphasia is 50 and the standard deviation is 10, with minimum and maximum possible scores of approximately 20 and 80, respectively.
Higher scores indicate better outcomes.
|
(1) 1 week prior to intervention; (2) immediately prior to intervention; (3) 1-2 days post intervention (4) 8 to 12 weeks post intervention
|
Collaborators and Investigators
Sponsor
Collaborators
Investigators
- Principal Investigator: William D Hula, Ph.D., VA Pittsburgh Healthcare System
- Principal Investigator: Patrick J Doyle, Ph.D., VA Pittsburgh Healthcare System
Publications and helpful links
General Publications
- Nicholas LE, Brookshire RH. A system for quantifying the informativeness and efficiency of the connected speech of adults with aphasia. J Speech Hear Res. 1993 Apr;36(2):338-50. doi: 10.1044/jshr.3602.338.
- Brookshire RH, Nicholas LE. Speech sample size and test-retest stability of connected speech measures for adults with aphasia. J Speech Hear Res. 1994 Apr;37(2):399-407. doi: 10.1044/jshr.3702.399.
- Fergadiotis G, Kellough S, Hula WD. Item Response Theory Modeling of the Philadelphia Naming Test. J Speech Lang Hear Res. 2015 Jun 1;58(3):865-877. doi: 10.1044/2015_JSLHR-L-14-0249.
- Hula WD, Doyle PJ, Stone CA, Austermann Hula SN, Kellough S, Wambaugh JL, Ross KB, Schumacher JG, St Jacque A. The Aphasia Communication Outcome Measure (ACOM): Dimensionality, Item Bank Calibration, and Initial Validation. J Speech Lang Hear Res. 2015 Jun;58(3):906-19. doi: 10.1044/2015_JSLHR-L-14-0235.
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- PRO00003086
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Aphasia
-
University of South CarolinaNational Institute on Deafness and Other Communication Disorders (NIDCD)CompletedStroke | Aphasia | Stroke, Ischemic | Aphasia, Broca | Aphasia, Anomic | Aphasia, Global | Aphasia, Fluent | Aphasia, Mixed | Aphasia, Jargon | Aphasia, Expressive | Aphasia, ConductionUnited States
-
University of Texas at AustinUniversity of California, San Francisco; National Institute on Deafness and...Active, not recruitingPrimary Progressive Aphasia | Aphasia | Semantic Dementia | Logopenic Progressive Aphasia | Semantic Memory Disorder | Nonfluent Aphasia, Progressive | Aphasia, ProgressiveUnited States
-
Institute for Bioengineering of CataloniaHospital Universitari Joan XXIII de Tarragona.; Universitat Pompeu FabraCompletedAphasia | Aphasia, Broca | Aphasia, Wernicke | Aphasia, Fluent | Aphasia, NonfluentSpain
-
Flint Rehabilitation Devices, LLCUniversity of TexasCompleted
-
Mayo ClinicNational Institute on Deafness and Other Communication Disorders (NIDCD)RecruitingPrimary Progressive Aphasia | Apraxia of Speech | PPA | Non-fluent Aphasia | Primary Progressive Non-fluent AphasiaUnited States
-
University of California, BerkeleyUniversity of California, San Francisco; California State University, East Bay and other collaboratorsRecruitingAphasia | Aphasia, Acquired | Aphasia Non Fluent | Aphasia, FluentUnited States
-
Mayo ClinicCompletedPrimary Progressive Aphasia | Aphasia | Semantic Dementia | Apraxia of Speech | Primary Progressive Nonfluent Aphasia | PPA | Non-fluent Aphasia | Progressive AphasiaUnited States
-
Montreal Heart InstituteActive, not recruitingNeurodegenerative Diseases | Primary Progressive Aphasia | Semantic Dementia | Logopenic Progressive Aphasia | Non-fluent AphasiaCanada
-
Johns Hopkins UniversityNational Institute on Aging (NIA)RecruitingPrimary Progressive Aphasia | Logopenic Progressive Aphasia | Non-Fluent Primary Progressive AphasiaUnited States, Canada
-
University of British ColumbiaTerminatedPrimary Progressive Nonfluent AphasiaCanada
Clinical Trials on Semantic Feature Analysis Treatment
-
Göteborg UniversityThe Swedish Research Council; Swedish Council for Working Life and Social ResearchCompletedStroke | Multiple Sclerosis | Parkinson Disease | Aphasia | AnomiaSweden
-
Boston University Charles River CampusNational Institute on Deafness and Other Communication Disorders (NIDCD)Recruiting
-
VA Office of Research and DevelopmentCompleted
-
US Department of Veterans AffairsCompletedLanguage Disorders | Aphasia | Speech DisordersUnited States
-
Penn State UniversityCompleted
-
VA Office of Research and DevelopmentUniversity of Washington; Portland State UniversityCompleted
-
Johns Hopkins UniversityNational Institute on Deafness and Other Communication Disorders (NIDCD)Recruiting
-
Medical College of WisconsinRecruitingStroke | AphasiaUnited States
-
Dr. Damian RedfearnRecruitingIschemic Ventricular Tachycardia (VT)Canada
-
Federal State Budgetary Institution, V. A. Almazov...Medicbook LLCCompletedAtrial Fibrillation | Arterial HypertensionRussian Federation