- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03991117
Lower and Higher Load Resistance Exercise Protocols: Acute Muscle Activation and Skeletal Muscle Hypertrophy
Muscle Fibre Activation is Unaffected by Load and Repetition Duration When Resistance Exercise is Performed to Task Failure
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
PROCEDURES INVOLVED IN THE RESEARCH
The total time commitment of this study will be ~7 hours. Each participant's first visit (familiarization) will include an interview through where the researchers will determine if there are any reasons that the participant cannot take part in the study. The researchers will explain the study protocol and, upon the participant's consent, the investigators will obtain the participant's knee extension maximum voluntary contraction (MVC) on a dynamometer (Biodex, Shirley, USA) and a 1 repetition-maximum (RM) test on a knee extension machine. Following that, the investigators will determine the next two dates (trial days) in which the participant will come in.
The participant will be asked to come in fasted on two separate trial days, each separated by two weeks, after the participant's familiarization visit. The participant will be required to avoid physical activity 48 hours before each of the three visits. There are four conditions in this study, each varying in relative load and speed of contraction. The participant will complete two conditions on each trial day, one with each leg. The conditions include: 80%RM Normal (80N; 1 eccentric: 1 pause: 1 concentric), 80% Slow (80S; 3:1:3), 30% Normal (30N; 1:1:1) and 30% Slow (30S; 3:1:3). Each condition will include three sets to voluntary failure on a knee extension machine. Before and after each set the participant will perform three MVCs on the dynamometer identical to what the participant did on the familiarization day. The investigators will record the participant's rating of perceived exertion and effort via the Borg scale and electromyography (EMG), respectively. The participant will have one biopsy taken pre-training and two, one per condition/leg, one hour post-training.
The REB Project Number for this study is: 802
Study Type
Enrollment (Actual)
Phase
- Not Applicable
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- healthy
- male
- 18-30 years of age
Exclusion Criteria:
- Have any acute or chronic illness such as cardiac, pulmonary, liver, or kidney abnormalities, uncontrolled hypertension, insulin- or non-insulin dependent diabetes or other metabolic disorders-all ascertained through a medical history screening questionnaire
- Experience arthritic conditions
- Smoke tobacco products
- Consume any analgesic or anti-inflammatory drug(s), prescription or non-prescription, chronically
- Have a history of neuromuscular complications
- Are on any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription strength acne medications).
- Have an extensive history of RE training in the year prior to study entry.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Basic Science
- Allocation: Randomized
- Interventional Model: Crossover Assignment
- Masking: Single
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: 80 %1RM, Regular Tempo
Participants performed three sets of unilateral knee extension with a load that was 80 % of their one-repetition maximum (1RM) at a tempo of three seconds per repetition.
|
unilateral knee extensions until fatigue with varying load and speeds of contraction
|
Experimental: 80 %1RM, Slow Tempo
Participants performed three sets of unilateral knee extension with a load that was 80 % of their one-repetition maximum (1RM) at a tempo of seven seconds per repetition.
|
unilateral knee extensions until fatigue with varying load and speeds of contraction
|
Experimental: 30 %1RM, Regular Tempo
Participants performed three sets of unilateral knee extension with a load that was 30 % of their one-repetition maximum (1RM) at a tempo of three seconds per repetition.
|
unilateral knee extensions until fatigue with varying load and speeds of contraction
|
Experimental: 30 %1RM, Slow Tempo
Participants performed three sets of unilateral knee extension with a load that was 30 % of their one-repetition maximum (1RM) at a tempo of seven seconds per repetition.
|
unilateral knee extensions until fatigue with varying load and speeds of contraction
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Concentration of glycogen in muscle fibres
Time Frame: three weeks
|
Histochemical assessment of muscle glycogen via muscle biopsies
|
three weeks
|
Amplitude of electrical activity above the quadriceps muscles
Time Frame: three weeks
|
Surface electromyography assessment via electrodes during the unilateral resistance exercise
|
three weeks
|
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Stuart Phillips, PhD, McMaster University
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- HIREB 0802
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
IPD Plan Description
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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