Risk Factors and Impact of Anesthesia Techniques on Myocardial Infarction Following Transurethral Resection of the Prostate

Risk Factors and Impact of Anesthesia Techniques on Myocardial Infarction Following Transurethral Resection of the Prostate: a Nationwide Database Case Control Study

This study examined the risk factors and the influence of the type of anesthetic used during transurethral resection of the prostate (TURP) on subsequent incidence of myocardial infarction (MI).

Study Overview

• Status: Completed
• Conditions: Myocardial Infarction; Anesthesia; Transurethral Resection of Prostate Syndrome
• Intervention / Treatment: Other: general anesthesia or neuraxial anesthesia

Detailed Description

This study utilized a population-based, nationwide dataset to evaluate the risk factors of MI for patients with benign prostate hypertrophy (BPH) who received TURP. Besides, The study also compared the different effects of general anesthesia (GA) and neuraxial anesthesia (NA) on the incidence of MI within 6 and 12 months after TURP.

• Study Type: Observational
• Enrollment (Actual): 115025

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult; Older Adult
• Accepts Healthy Volunteers: N/A
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Patients receiving TURP

Description

Inclusion Criteria:

• Patients receiving TURP surgery (1998-2012)

Exclusion Criteria:

• Patients without anesthesia records
• Patients receiving both general and neuraxial anesthesia
• Mortality within 12 months of TURP

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Without post-operative myocardial infarction; Patients without post-operative myocardial infarction after first admission for transurethral resection of the prostate	Other: general anesthesia or neuraxial anesthesia
With post-operative myocardial infarction; Patients with post-operative myocardial infarction after first admission for transurethral resection of the prostate	Other: general anesthesia or neuraxial anesthesia

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Postoperative myocardial infarction	Patients experienced myocardial infarction after transurethral resection of the prostate (TURP)	within 6 months after the first admission for TURP
Postoperative myocardial infarction	Patients experienced myocardial infarction after transurethral resection of the prostate (TURP)	within 12 months after the first admission for TURP
Patient's age (year-old) that developed post-TURP myocardial infarction	We analyze age distribution of patients with post-TURP myocardial infarction	within 6 months after the first admission for TURP
Patient's age (year-old) that developed post-TURP myocardial infarction	We analyze age distribution of patients with post-TURP myocardial infarction	within 12 months after the first admission for TURP
Number of patients with pre-operative diagnosed Diabetes Mellitus developing post-TURP myocardial infarction	We analyze pre-operative diagnosed Diabetes Mellitus rate in patients who had myocardial infarction after the surgery of TURP.	within 6 months after the first admission for TURP
Number of patients with pre-operative diagnosed Diabetes Mellitus developing post-TURP myocardial infarction	We analyze pre-operative diagnosed Diabetes Mellitus rate in patients who had myocardial infarction after the surgery of TURP.	within 12 months after the first admission for TURP
Number of patients with pre-operative diagnosed disorders of lipoid metabolism developing post-TURP myocardial infarction	We analyze pre-operative diagnosed disorders of lipoid metabolism rate in patients who had myocardial infarction after the surgery of TURP.	within 6 months after the first admission for TURP
Number of patients with pre-operative diagnosed disorders of lipoid metabolism developing post-TURP myocardial infarction	We analyze pre-operative diagnosed disorders of lipoid metabolism rate in patients who had myocardial infarction after the surgery of TURP.	within 12 months after the first admission for TURP
Number of patients with pre-operative diagnosed gout developing post-TURP myocardial infarction	We analyze pre-operative diagnosed gout rate in patients who had myocardial infarction after the surgery of TURP.	within 6 months after the first admission for TURP
Number of patients with pre-operative diagnosed gout developing post-TURP myocardial infarction	We analyze pre-operative diagnosed gout rate in patients who had myocardial infarction after the surgery of TURP.	within 12 months after the first admission for TURP
Number of patients with pre-operative diagnosed hypertension developing post-TURP myocardial infarction	We analyze pre-operative diagnosed hypertension rate in patients who had myocardial infarction after the surgery of TURP.	within 6 months after the first admission for TURP
Number of patients with pre-operative diagnosed hypertension developing post-TURP myocardial infarction	We analyze pre-operative diagnosed hypertension rate in patients who had myocardial infarction after the surgery of TURP.	within 12 months after the first admission for TURP
Number of patients with pre-operative diagnosed heart disease history developing post-TURP myocardial infarction	We analyze pre-operative diagnosed heart disease rate in patients who had myocardial infarction after the surgery of TURP.	within 6 months after the first admission for TURP
Number of patients with pre-operative diagnosed heart disease history developing post-TURP myocardial infarction	We analyze pre-operative diagnosed heart disease rate in patients who had myocardial infarction after the surgery of TURP.	within 12 months after the first admission for TURP
Number of patients with pre-operative diagnosed stroke history developing post-TURP myocardial infarction	We analyze pre-operative diagnosed stroke rate in patients who had myocardial infarction after the surgery of TURP.	within 6 months after the first admission for TURP
Number of patients with pre-operative diagnosed stroke history developing post-TURP myocardial infarction	We analyze pre-operative diagnosed stroke rate in patients who had myocardial infarction after the surgery of TURP.	within 12 months after the first admission for TURP
Number of patients with pre-operative diagnosed liver cirrhosis history developing post-TURP myocardial infarction	We analyze pre-operative diagnosed liver cirrhosis rate in patients who had myocardial infarction after the surgery of TURP.	within 6 months after the first admission for TURP
Number of patients with pre-operative diagnosed liver cirrhosis history developing post-TURP myocardial infarction	We analyze pre-operative diagnosed liver cirrhosis rate in patients who had myocardial infarction after the surgery of TURP.	within 12 months after the first admission for TURP
Number of patients with pre-operative diagnosed chronic obstructive pulmonary disease developing post-TURP myocardial infarction	We analyze pre-operative diagnosed chronic obstructive pulmonary disease rate in patients who had myocardial infarction after the surgery of TURP.	within 6 months after the first admission for TURP
Number of patients with pre-operative diagnosed chronic obstructive pulmonary disease developing post-TURP myocardial infarction	We analyze pre-operative diagnosed chronic obstructive pulmonary disease rate in patients who had myocardial infarction after the surgery of TURP.	within 12 months after the first admission for TURP
Number of patients with pre-operative diagnosed asthma developing post-TURP myocardial infarction	We analyze pre-operative diagnosed asthma rate in patients who had myocardial infarction after the surgery of TURP.	within 6 months after the first admission for TURP
Number of patients with pre-operative diagnosed asthma developing post-TURP myocardial infarction	We analyze pre-operative diagnosed asthma rate in patients who had myocardial infarction after the surgery of TURP.	within 12 months after the first admission for TURP

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Number of patients who had post-operative myocardial infarction after receiving general anesthesia for TURP	Number of patients who had post-operative myocardial infarction after receiving general anesthesia for TURP	within 6 months after the first admission for TURP
Number of patients who had post-operative myocardial infarction after receiving neuraxial anesthesia for TURP	Number of patients who had post-operative myocardial infarction after receiving neuraxial anesthesia for TURP	within 6 months after the first admission for TURP
Number of patients who did not have post-operative myocardial infarction after receiving general anesthesia for TURP	Number of patients who did not have post-operative myocardial infarction after receiving general anesthesia for TURP	within 12 months after the first admission for TURP
Number of patients who did not have post-operative myocardial infarction after receiving neuraxial anesthesia for TURP	Number of patients who did not have post-operative myocardial infarction after receiving neuraxial anesthesia for TURP	within 12 months after the first admission for TURP

Collaborators and Investigators

• Sponsor: Chang Gung Memorial Hospital

Study record dates

Study Major Dates

• Study Start (Actual): January 1, 1998
• Primary Completion (Actual): December 31, 2012
• Study Completion (Actual): March 22, 2016

Study Registration Dates

• First Submitted: July 23, 2019
• First Submitted That Met QC Criteria: August 5, 2019
• First Posted (Actual): August 6, 2019

Study Record Updates

• Last Update Posted (Actual): August 7, 2019
• Last Update Submitted That Met QC Criteria: August 5, 2019
• Last Verified: September 1, 2015

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Ischemia; Pathologic Processes; Necrosis; Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Vascular Diseases; Myocardial Infarction; Infarction; Physiological Effects of Drugs; Central Nervous System Depressants; Anesthetics
• Other Study ID Numbers: 104-6697B

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No