Serum Folic Acid Status, Genotyping MTHFR 677C-->T, Plasma Homocysteine, DNA Methylation of IGF2 Gene and Microbiota of the Children: Mother-Children Cohort Study

Serum Folic Acid Status, Genotyping MTHFR 677C-->T of the Mother and Serum Folic Acid Status, DNA Methylation of IGF2 Gene of the Children: East Jakarta Cohort Study

Sponsors

Lead Sponsor: Indonesia University

Collaborator: Ministry of Research and Higher Education of Republic Indonesia
United States Agency for International Development (USAID)

Source Indonesia University
Brief Summary

This study is part of the East Jakarta Cohort Study to assess the current micronutrient status of the mothers and their children. The study also includes the assessment of genotyping of MTHFR 677C-->T of the mother and DNA methylation of IGF2 gene of the children.

Detailed Description

The initial study recruited 315 mothers in the public health centre and one district hospital in East Jakarta. The follow-up study is able to re-visit the 127 of them. This also includes 127 peers of the subject that lives in the same neighbourhood. The design of the study is case-cohort design, part study of the existing cohort. The assessment of the follow-up study includes the mother and the children born in the initial study. Anthropometric measurement, socioeconomic data from a structured questionnaire, biomarker assessment, blood pressure were obtained from the subjects.

Overall Status Completed
Start Date August 2, 2018
Completion Date March 16, 2019
Primary Completion Date November 20, 2018
Study Type Observational
Primary Outcome
Measure Time Frame
Serum folic acid status December 2018 - March 2019
Genotyping MTHFR 677C-->T December 2018 - March 2019
DNA methylation of IGF2 gene December 2018 - March 2019
Secondary Outcome
Measure Time Frame
Serum Homocysteine December 2018-March 2019
Serum Adiponectin December 2018-March 2019
Blood pressure December 2018-March 2019
Enrollment 254
Condition
Eligibility

Sampling Method: Non-Probability Sample

Criteria:

Inclusion Criteria:

- participant in the previous study

- apparently healthy

- data complete

- voluntarily to participate

Exclusion Criteria:

- not complete data

- migrate

- refuse to participate in the study

Gender: All

Minimum Age: 3 Years

Maximum Age: 40 Years

Healthy Volunteers: No

Overall Official
Last Name Role Affiliation
Rina RA Agustina, Doctoral Study Director Indonesia University
Location
Facility: Universitas Indonesia
Location Countries

Indonesia

Verification Date

December 2019

Responsible Party

Type: Principal Investigator

Investigator Affiliation: Indonesia University

Investigator Full Name: Lestari Octavia

Investigator Title: MSc

Keywords
Has Expanded Access No
Condition Browse
Arm Group

Label: East Jakarta Cohort Study

Description: One group included in the study was originated from mothers who participated in the first data collection pregnancy. The follow-up study included mothers and their children born as the subject in the follow-up in the study. This study also includes peer of the subjects that lived in the same neighbourhood since the first cohort study and have children in the same age with cohort participant

Patient Data No
Study Design Info

Observational Model: Cohort

Time Perspective: Prospective

Source: ClinicalTrials.gov