- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04098185
Role of Pleural Fluid Attenuation Value on CT as a Diagnostic Tool in Traumatic Hemothorax
Role of Pleural Fluid Attenuation Value Measurement on Computed Tomography as a Diagnostic Tool for Hemothorax in Traumatic Patients
Study Overview
Detailed Description
Hemothorax is defined as blood accumulation in the pleural space. It is a consequence of blunt trauma in 90% of cases. Hemothorax due to blunt trauma mechanisms e.g traffic accidents,sport accidents and falls are among the commonest injuries of the chest. It is manifested in 30-50% of chest trauma cases. In such cases, bleeding might be caused by damage to pulmonary parenchyma or intercostal arteries associated with or without rib fractures and other chest wall tissue injuries including parietal pleura or other thoracic structures. Although other pleural effusion types may also manifest such as chylothorax in case of chest trauma, however fluid detected in pleural space is usually considered blood unless proven not to be. Despite the clinical and radiological findings provide important data about the content of pleural cavity, however tube thoracostomy and diagnostic thoracocentesis are still required to relieve pressure and characterize the fluid. Tube thoracostomy is an invasive procedure which can lead to immediate procedural injuries, infections and pain which can contribute to respiratory failure in patients with chest wall injury. Although needle thoracocentesis is less invasive than tube thoracostomy, however it carries small but definitive risks such as pneumothorax, bleeding and chest wall hematoma. Since hemothorax is a potentially life threatening, it must be diagnosed quickly and accurately and all these unnecessary complications should be avoided. Chest computed tomography [CT] has been accepted as the gold standard imaging study for evaluating chest trauma and usually performed in patients with grossly severe chest trauma, as it helps to detect even small hemothorax.
CT can also allow for more advanced characterization of pleural fluid and distinguish hemothorax from any other types of effusion by means of scaling Hounsfield units as in literature, any attenuation value for pleural fluid between 35 and 70 HU is considered typically blood, so it can be considered as an important non-invasive diagnostic tool for diagnosis of hemothorax in traumatic patients.
Study Type
Enrollment (Anticipated)
Contacts and Locations
Study Contact
- Name: Ghada Abdelazem Abdelbary, Dr
- Phone Number: 00201098815249
- Email: khalid.kamal1987@yahoo.com
Study Contact Backup
- Name: Eman proffesor Abo Elhamd, Prof Dr
- Phone Number: 00201001980793
- Email: dr.eman_08@yahoo.com
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
- All patients above 18 years old
- History of blunt chest trauma
- Having mild to moderate effusion
- CT chest within 1st 24 hours of trauma
- Patients underwent tube thoracostomy or thoracocentesis
Exclusion Criteria:
- Patients in need of emergency transfer to surgery.
- Hemodynamically stable.
- Patients with penetrating trauma.
- Patients with no need for tube thoracostomy or thoracocentesis.
- Patients with minimal effusion.
- Pregnant females.
Study Plan
How is the study designed?
Design Details
- Observational Models: Cohort
- Time Perspectives: Prospective
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Role of pleural fluid attenuation value measurement on CT as a diagnostic tool for traumatic hemothorax
Time Frame: from 1 December 2019 to 1 December 2020
|
Measurements of pleural effusion attenuation value on CT to diagnose traumatic hemothorax and differentiate it from other types of pleural effusion.
|
from 1 December 2019 to 1 December 2020
|
Collaborators and Investigators
Sponsor
Publications and helpful links
General Publications
- Hooper C, Lee YC, Maskell N; BTS Pleural Guideline Group. Investigation of a unilateral pleural effusion in adults: British Thoracic Society Pleural Disease Guideline 2010. Thorax. 2010 Aug;65 Suppl 2:ii4-17. doi: 10.1136/thx.2010.136978. No abstract available.
- Sridhar S, Raptis C, Bhalla S. Imaging of Blunt Thoracic Trauma. Semin Roentgenol. 2016 Jul;51(3):203-14. doi: 10.1053/j.ro.2015.12.002. Epub 2015 Dec 18. No abstract available.
- Meyer DM. Hemothorax related to trauma. Thorac Surg Clin. 2007 Feb;17(1):47-55. doi: 10.1016/j.thorsurg.2007.02.006.
- Sangster GP, Gonzalez-Beicos A, Carbo AI, Heldmann MG, Ibrahim H, Carrascosa P, Nazar M, D'Agostino HB. Blunt traumatic injuries of the lung parenchyma, pleura, thoracic wall, and intrathoracic airways: multidetector computer tomography imaging findings. Emerg Radiol. 2007 Oct;14(5):297-310. doi: 10.1007/s10140-007-0651-8. Epub 2007 Jul 11.
- Miller LA. Chest wall, lung, and pleural space trauma. Radiol Clin North Am. 2006 Mar;44(2):213-24, viii. doi: 10.1016/j.rcl.2005.10.006.
- Mirvis SE. Imaging of acute thoracic injury: the advent of MDCT screening. Semin Ultrasound CT MR. 2005 Oct;26(5):305-31. doi: 10.1053/j.sult.2005.08.001.
- Romero M, Bachler P. Pseudo-hemothorax at computed tomography due to residual contrast media. Clin Imaging. 2014 May-Jun;38(3):333-5. doi: 10.1016/j.clinimag.2014.01.004. Epub 2014 Jan 16.
- Kaewlai R, Avery LL, Asrani AV, Novelline RA. Multidetector CT of blunt thoracic trauma. Radiographics. 2008 Oct;28(6):1555-70. doi: 10.1148/rg.286085510.
- Gordon CE, Feller-Kopman D, Balk EM, Smetana GW. Pneumothorax following thoracentesis: a systematic review and meta-analysis. Arch Intern Med. 2010 Feb 22;170(4):332-9. doi: 10.1001/archinternmed.2009.548.
- Liu F, Huang YC, Ng YB, Liang JH. Differentiatepleural effusion from hemothorax after bluntchest trauma; comparison of computed tomography attenuation values. Journal of AcuteMedicine 2016; 6: 1-6.
- Cummings KW, Javidan-Nejad C, Bhalla S. Multidetector computed tomography of nonosseous thoracic trauma. Semin Roentgenol. 2014 Apr;49(2):134-42. doi: 10.1053/j.ro.2014.01.002. Epub 2014 Jan 28. No abstract available.
- Bolus D, Morgan D, Berland L. Effective use of the Hounsfield unit in the age of variable energy CT. Abdom Radiol (NY). 2017 Mar;42(3):766-771. doi: 10.1007/s00261-017-1052-4.
Study record dates
Study Major Dates
Study Start (Anticipated)
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- CT in traumatic hemothorax
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
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