- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04245306
Pilot Evaluation of a New Computerized Test for Pragmatic Inferences in Children With ASD (TIPI)
March 23, 2022 updated by: Hôpital le Vinatier
Pilot Evaluation of a New Computerized Test for Pragmatic Inferences in Children With Autism Spectrum Disorder Aged 8-12 Years Old
This study aims to evaluate the relevance of a new computerized test for pragmatic inferences (TIPi) in children aged 8 to 12 YO, presenting a typical development, autism spectrum disorders or another neurodevelopmental condition.
Study Overview
Status
Recruiting
Conditions
Intervention / Treatment
Detailed Description
By virtue of pragmatic inference-making, a listener can go above and beyond the linguistic meaning of the speaker's utterance in order to understand what the speaker intended to communicate.
Such inferences allow the listener to understand inter alia irony, metaphor, indirect requests, scalar and ad-hoc implicatures.
Autistic individuals have typically been described, by clinicians and language specialists, as tending towards having a literal understanding of language and as being deficient with respect to understanding a speaker's intended meaning, and these difficulties have a major impact on quality of life and social participation.
Therefore, assessing these abilities seems essential, both for diagnosis purpose and to draw a clear description of an individual's functioning profile.
Yet, no tool is available for children aged 8 to 12 in French.
A new test named TIPi has been developed to resolve this issue.
This new test is computerized and runs in a touch pad.
The main goal of the present study is to evaluate the ability of the TIPi to discriminate autism spectrum disorders (ASD) children from typically developing (TD) children.
Secondary goals are (i) to measure the typical development of these abilities in TD children in this age range, (ii) to assess the developmental link these skills might have with other cognitive of language abilities (mentalizing, cognitive flexibility, core language skills, central coherence), and (iii) to compare the pragmatic profile of ASD children with another neurodevelopmental condition: developmental language disorder, in order to test the relevance of this test for differential diagnosis.
Study Type
Interventional
Enrollment (Anticipated)
200
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Contact
- Name: Nicolas PETIT
- Phone Number: +33 0437915256
- Email: nicolas.petit@ch-le-vinatier.fr
Study Locations
-
-
-
Bron, France, 69678
- Recruiting
- CH Le Vinatier
-
Contact:
- Nicolas PETIT
- Phone Number: +33 04 37 91 52 84
- Email: nicolas.petit@ch-le-vinatier.fr
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
8 years to 12 years (Child)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Age between 8 and 12 years old
- Native French speaker
- Informed consent of the parents and children
- [For ASD group] Diagnosis of ASD provided by a trained and entitled clinician
- [For DLD group] Diagnosis of DLD provided by a trained and entitled clinician
- [For ASD and DLD groups] IQ above 70
Exclusion Criteria:
- Uncorrected visual impairment
- Uncorrected auditory impairment
- Motor disability preventing the use of a touch pad
- [For the TD group] Diagnosis of any neurodevelopmental or psychiatric condition
- [For ASD group] Diagnosis of language disorder of attention disorder (ADHD)
- [For DLD group] Diagnosis of ASD or ADHD
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Diagnostic
- Allocation: Non-Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Children with Autism Spectrum Disorders
A group of 25 children with autism spectrum disorders (ASD)
|
Computerized tests
|
Active Comparator: Typically Developing children
A larger group of 150 typically developing children (TD)
|
Computerized tests
|
Experimental: Children with Developmental Language Disorders
A group of 25 children with developmental language disorders (DLD)
|
Computerized tests
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Discrimination power of the measure assessed by the dissociation of the developmental trajectories of children with ASD compared to TD children in the composite score of the TIPi.
Time Frame: One day
|
The dissociation between the developmental trajectories of these two groups will be assessed by comparing the coefficients of the linear regressions linking performance in the TIPi (composite score) and chronological age in these two groups.
|
One day
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Sensitivity of the TIPi composite score (measuring pragmatic inferencing) to typical development in the targeted age range: 8 to 12 years oldin the targeted age range: 8 to 12 years old
Time Frame: One day
|
Sensitivity to age of the TIPi composite score is assessed by the alpha coefficient of the regression analysis linking the composite score to chronological age in the TD group.
|
One day
|
The TIPi composite score provides additional information compared to other cognitive assessments typically provided in the global assessment of children with ASD
Time Frame: One day
|
The predictive power of the best fitted multiple regression model explaining this measure by - jointly - performances in language task, mentalizing task, cognitive flexibility task, central coherence task and age (this predictive power being measured by the adjusted R2 of the model).
|
One day
|
Discrimination power of the measure assessed by the dissociation of the developmental trajectories of children with ASD compared to children with DLD in the composite score of the TIPi.
Time Frame: One day
|
The dissociation between the developmental trajectories of these two groups will be assessed by comparing the coefficients of the linear regressions linking performance in the TIPi (composite score) and chronological age in these two groups.
|
One day
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
February 7, 2020
Primary Completion (Actual)
February 7, 2020
Study Completion (Anticipated)
February 7, 2023
Study Registration Dates
First Submitted
January 17, 2020
First Submitted That Met QC Criteria
January 27, 2020
First Posted (Actual)
January 28, 2020
Study Record Updates
Last Update Posted (Actual)
March 24, 2022
Last Update Submitted That Met QC Criteria
March 23, 2022
Last Verified
July 1, 2021
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 2019-A01721-56
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
No
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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