EFFECT OF ANESTHESİA TECHNIQUES ON POSTOPERATİVE COGNİTİVE DYSFUNCTION FOR MMSE AND NSE LEVEL

THE EFFECT OF TOTAL INTRAVENOUS ANESTHESIA AND INHALATION ANESTHESIA TECHNIQUES FOR MINI MENTAL STATE EXAMINATION TEST AND NEURON SPECIFIC ENOLASE LEVEL IN LUMBAR DISK HERNIECTOMY OPERATIONS

The aim of this study is to compare the effects of total intravenous anesthesia and inhalation anesthesia methods on postoperative cognitive dysfunction according to Mini Mental State Examination scores and Neuron Specific Enolase levels in lumbar disc herniectomy operations.

Study Overview

• Status: Unknown
• Conditions: Postoperative Cognitive Dysfunction; NEURON SPECIFIC ENOLASE; MINI MENTAL STATE EXAMINATION TEST
• Intervention / Treatment: Behavioral: POSTOPERATIVE COGNITIVE DYSFUNCTION

• Study Type: Observational
• Enrollment (Anticipated): 80

Contacts and Locations

• Study Contact: Name: UFUK KUYRUKLUYILDIZ; Phone Number: 05325840554; Email: drufuk2001@gmail.com

Study Locations

• Turkey
  • Erzincan, Turkey
    • Recruiting
    • Erzincan Byu
    • Contact: TÜLAY CEREN ÖLMEZTÜRK KARAKURT; Phone Number: 05058616006; Email: ceren_olmezturk_@hotmail.com

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 65 years (ADULT, OLDER_ADULT)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Lumbal disc herniectomy operation is planned for ASA I, II and III risk group between the ages of 18-65.

Description

Inclusion Criteria:

-Lumbal disc herniectomy operation 18-65 age

Exclusion Criteria:

• Patients before and after the coronary artery bypass graft surgery
• patients in the last trimester of pregnancy
• patients with severe heart failure
• liver failure
• kidney failure
• malignant hyperthermia
• lactating patients
• patients with vision or hearing problems
• patients having difficulty in understanding and speaking Turkish
• Parkinson's and Alzheimer's disease
• alcohol and drug addicts
• morbidly obese patients
• intraoperative hypotension, hypertension and hypoxemia

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
TOTAL INTRAVENOUS ANESTHESIA	Behavioral: POSTOPERATIVE COGNITIVE DYSFUNCTION; NEURON SPECIFIC ENOLASE LEVELS IN LUMBAR DISC HERNIECTOMY WITH GENERAL ANESTHESIA MODALITIES
INHALATION ANESTHESIA	Behavioral: POSTOPERATIVE COGNITIVE DYSFUNCTION; NEURON SPECIFIC ENOLASE LEVELS IN LUMBAR DISC HERNIECTOMY WITH GENERAL ANESTHESIA MODALITIES

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
MINI MENTAL STATE EXAMINATION TEST	BELOW 27 SCORE IS ASSOSIATED WITH POSTOPERATIVE COGNITIVE DYSFUNCTION	1 MONTH

Collaborators and Investigators

• Sponsor: Erzincan University
• Investigators: Principal Investigator: TÜLAY CEREN ÖLMEZTÜRK KARAKURT, Erzincan Byu

Publications and helpful links

General Publications

• Goswami U, Babbar S, Tiwari S. Comparative evaluation of the effects of propofol and sevoflurane on cognitive function and memory in patients undergoing laparoscopic cholecystectomy: A randomised prospective study. Indian J Anaesth. 2015 Mar;59(3):150-5. doi: 10.4103/0019-5049.153036.
• Luescher T, Mueller J, Isenschmid C, Kalt J, Rasiah R, Tondorf T, Gamp M, Becker C, Sutter R, Tisljar K, Schuetz P, Marsch S, Hunziker S. Neuron-specific enolase (NSE) improves clinical risk scores for prediction of neurological outcome and death in cardiac arrest patients: Results from a prospective trial. Resuscitation. 2019 Sep;142:50-60. doi: 10.1016/j.resuscitation.2019.07.003. Epub 2019 Jul 12.
• Baysalman HB, Oğuz G, Açıkgöz G, Aksakal FN, Ünver SJJotTA, Dergisi ICS-JTAvR. Total İntravenöz ve Desfluran Anestezilerinin Erken Derlenme ve Kognitif Fonksiyonlara Etkileri. 2011;39(1).

Study record dates

Study Major Dates

• Study Start (ANTICIPATED): March 21, 2020
• Primary Completion (ANTICIPATED): May 21, 2020
• Study Completion (ANTICIPATED): July 21, 2020

Study Registration Dates

• First Submitted: February 19, 2020
• First Submitted That Met QC Criteria: February 19, 2020
• First Posted (ACTUAL): February 20, 2020

Study Record Updates

• Last Update Posted (ACTUAL): February 20, 2020
• Last Update Submitted That Met QC Criteria: February 19, 2020
• Last Verified: February 1, 2020

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Mental Disorders; Pathologic Processes; Postoperative Complications; Neurocognitive Disorders; Cognition Disorders; Cognitive Dysfunction; Postoperative Cognitive Complications
• Other Study ID Numbers: 19/10

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No