Impact of Augmenting Exercise Intensity vs. Frequency

Impact of Augmenting Exercise Intensity vs. Frequency on Peak Work Rate

The purpose of this study is to compare the impact of augmenting exercise intensity and augmenting exercise frequency on peak work rate. Participants will complete exercise tests and provide 8 skeletal muscle samples following a within-subjects randomized crossover design utilizing single-leg cycling. Both training periods will be 4 weeks long and skeletal muscle biopsies will be collected from both legs before and after each training period. All exercise sessions will be supervised, take place in the investigator's laboratory, and occur on stationary bikes.

Study Overview

• Status: Unknown
• Conditions: Exercise Training
• Intervention / Treatment: Behavioral: Frequency comparison; Behavioral: Intensity comparison

• Study Type: Interventional
• Enrollment (Actual): 16
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Canada
  • Ontario
    • Kingston, Ontario, Canada, K7L 3N6
      • Queen's Muscle Physiology Lab in the School of Kinesiology and Health Studies at Queen's University

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 30 years (Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Recreational active (<3 hours per week of aerobic exercise)
• Willing to provide skeletal muscle biopsies

Exclusion Criteria:

• Cardiovascular or metabolic disease
• Athletes or individuals exceeding 3 hours per week of aerobic exercise
• Smokers

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: Randomized
• Interventional Model: Crossover Assignment
• Masking: Single

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Frequency then Intensity; Training period 1: Frequency comparison Training period 2: Intensity comparison	Behavioral: Frequency comparison; One leg assigned to low-frequency low-intensity (3 days per week of 11 x 1 min @ 73% peak work rate interspersed with 1-minute periods of active recovery). The other leg assigned to high-frequency low-intensity (5 days per week of 11 x 1 min @ 73% peak work rate interspersed with 1-minute periods of active recovery).; Behavioral: Intensity comparison; One leg assigned to low-frequency low-intensity (3 days per week of 11 x 1 min @ 73% peak work rate interspersed with 1-minute periods of active recovery). The other leg assigned to low-frequency high-intensity (3 days per week of 8 x 1 min @ 100% peak work rate interspersed with 1-minute periods of active recovery).
Experimental: Intensity then Frequency; Training period 1: Intensity comparison Training period 2: Frequency comparison	Behavioral: Frequency comparison; One leg assigned to low-frequency low-intensity (3 days per week of 11 x 1 min @ 73% peak work rate interspersed with 1-minute periods of active recovery). The other leg assigned to high-frequency low-intensity (5 days per week of 11 x 1 min @ 73% peak work rate interspersed with 1-minute periods of active recovery).; Behavioral: Intensity comparison; One leg assigned to low-frequency low-intensity (3 days per week of 11 x 1 min @ 73% peak work rate interspersed with 1-minute periods of active recovery). The other leg assigned to low-frequency high-intensity (3 days per week of 8 x 1 min @ 100% peak work rate interspersed with 1-minute periods of active recovery).

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Peak work rate	Change in Highest work rate achieved (30s period) during incremental exercise tests	Before exercise training on two days (~7 and 6 days before first training session; ~24 hours apart), and after exercise on two days (~48-96 hours after the last training session; ~24 hours apart)

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Peak oxygen uptake	Change in Highest oxygen uptake achieved (30s period) during incremental exercise tests	Before exercise training on two days (~7 and 6 days before first training session; ~24 hours apart), and after exercise on two days (~48-96 hours after the last training session; ~24 hours apart)
Maximal citrate synthase activity	Change in maximal citrate synthase activity	Before exercise training (~7 days before first training session), and after exercise training (~48-72 hours after the last training session)

Collaborators and Investigators

• Sponsor: Brendon Gurd, PhD
• Collaborators: Queen's University

Study record dates

Study Major Dates

• Study Start (Actual): September 30, 2019
• Primary Completion (Anticipated): April 10, 2020
• Study Completion (Anticipated): April 10, 2020

Study Registration Dates

• First Submitted: March 2, 2020
• First Submitted That Met QC Criteria: March 3, 2020
• First Posted (Actual): March 4, 2020

Study Record Updates

• Last Update Posted (Actual): March 4, 2020
• Last Update Submitted That Met QC Criteria: March 3, 2020
• Last Verified: March 1, 2020

More Information

Terms related to this study

• Other Study ID Numbers: UCD Study

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No