Investigation of the Efficacies of a Resveratrol Formula on Improvement of Skin Conditions and Inflammatory Related Factors (Resveratrol)

Investigation of the Efficacies of a Resveratrol Formula on Improvement of Skin

To assess a resveratrol formula on improvement of skin conditions and inflammatory cytokines in blood

Study Overview

• Status: Completed
• Conditions: Skin Conditions; Proinflammatory Cytokines
• Intervention / Treatment: Dietary supplement: Resveratrol drink; Dietary supplement: Placebo drink

• Study Type: Interventional
• Enrollment (Actual): 60
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Taiwan
  • Tainan City, Taiwan, 71710
    • Chia Nan University of Pharmacy & Science

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 20 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Healthy volunteers aged above 20 years old

Exclusion Criteria:

• Subject who is not willing to participate in this study.
• Patients with diseases of the skin, heart, liver, kidney, endocrine and other organs and patients with mental illness (according to medical history).
• Subjects who have known cosmetic, drug or food allergies, difficulty in digestive tract absorption or disorder.
• Female who is pregnant or nursing or planning to become pregnant during the course of the study.
• Received facial laser therapy, chemical peeling or UV overexposure in the past 4 weeks.
• Subjects who have large spots (area >3 square centimeter) or abnormal acne.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Prevention
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Single

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Placebo Comparator: Placebo drink	Dietary supplement: Placebo drink; Subjects will consume a bottle of placebo drink for two months.
Experimental: Resveratrol drink	Dietary supplement: Resveratrol drink; Subjects will consume a bottle of resveratrol drink for two months.; Other Names: Grape Yeast Compound Fruit Vegetable Beverage

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
The change of skin moisture	Corneometer® CM825 was utilized to measure skin moisture. Units: arbitrary Corneometer® units 0-120	0, 4, and 8 weeks
The change of skin elasticity	Cutometer® dual MPA 580 was utilized to measure skin elasticity (parameter R2). Units: μm penetration depth into the probe opening, expressed as curves	0, 4, and 8 weeks
The change of skin wrinkles	VISIA Complexion Analysis System was utilized to measure wrinkles. Units: arbitrary units	0, 4, and 8 weeks
The change of skin collagen density	DermaLab® USB - 20 MHz High Freq. Ultrasound probe was utilized to scan and analyze skin collagen density. Units: Intensity score	0, 4, and 8 weeks
The change of skin texture	VISIA Complexion Analysis System was utilized to measure skin texture. Units: arbitrary units	0, 4, and 8 weeks
The change of skin pores	VISIA Complexion Analysis System was utilized to measure skin pores. Units: arbitrary units	0, 4, and 8 weeks
The change of total antioxidant capacity of blood	Total Antioxidant Capacity Assay Kit	0 and 8 weeks
The change of TNF-alpha of blood	ELISA Kit	0 and 8 weeks
The change of IL-6 of blood	ELISA Kit	0 and 8 weeks
The change of IL-17 of blood	ELISA Kit	0 and 8 weeks
The change of IL-1β of blood	ELISA Kit	0 and 8 weeks

Collaborators and Investigators

• Sponsor: TCI Co., Ltd.

Study record dates

Study Major Dates

• Study Start (Actual): September 17, 2020
• Primary Completion (Actual): November 10, 2020
• Study Completion (Actual): December 31, 2020

Study Registration Dates

• First Submitted: June 30, 2020
• First Submitted That Met QC Criteria: June 30, 2020
• First Posted (Actual): July 7, 2020

Study Record Updates

• Last Update Posted (Actual): January 15, 2021
• Last Update Submitted That Met QC Criteria: January 13, 2021
• Last Verified: January 1, 2021

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Pathologic Processes; Disease; Skin Diseases; Physiological Effects of Drugs; Molecular Mechanisms of Pharmacological Action; Enzyme Inhibitors; Platelet Aggregation Inhibitors; Protective Agents; Antioxidants; Resveratrol
• Other Study ID Numbers: 20-0-54-B

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No