- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04546243
Osteosarcoma With Resectable Pulmonary Metastasis: A Retrospective Study
December 3, 2020 updated by: Peking University People's Hospital
A Retrospective Study Investigating Survival for High-grade Osteosarcoma Patients Who Had Achieved First Complete Surgical Remission (SCR) During Combined-modality Therapy in Two Hospitals Affiliated to Peking University
According to EURAMOS-1, 17% of osteosarcoma patients were considered to have metastases at diagnosis.
In this selected cohort, the reported 5-year EFS from diagnosis of 28% compares well to previous results reported from unselected cohorts of patients with only lung metastases.
Resection of pulmonary metastases from osteosarcoma is a treatment option which has been shown to correlate with survival benefit and cure in select individuals.
These patients are best addressed in a multidisciplinary fashion, with the involvement of a thoracic surgeon with experience in pulmonary metastasectomy.
At the same time, the goal of surgical resection of pulmonary metastases from osteosarcoma is to render the patient completely disease free.
"Tumor debulking" or "cytoreductive surgery" with incomplete resection has not demonstrated any survival benefit for patients with pulmonary metastases.
Thus open thoracotomy is more preferred than VATS.
However over the last decade in China, thoracotomy has not been adopted generally.
More patients had chosen VATS or even hypo-fractionation radiotherapy, such as gamma knife, cyber knife and so on as a local treatment method.
This study aims to investigate the survival of consecutive patients who had achieved a first complete surgical remission (CR) during combined-modality therapy on neoadjuvant or adjuvant PKUPH-OS protocol so as to discuss reasonable local therapy for resectable pulmonary osteosarcoma metastatic lesions.
Study Overview
Status
Completed
Intervention / Treatment
Study Type
Observational
Enrollment (Actual)
127
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
Beijing
-
Beijing, Beijing, China, 100044
- Peking University People's Hospital
-
Beijing, Beijing, China, 100036
- Peking University Shougang Hospital
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
- ADULT
- OLDER_ADULT
- CHILD
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Sampling Method
Non-Probability Sample
Study Population
This report includes all the patients with recurrences from a previously treated cohort of 678 consecutive, newly diagnosed patients with localized or primary metastatic high-grade osteosarcoma of the trunk or limbs registered onto the neoadjuvant studies of Peking University People's Hospital and Peking University Shougang Hospital between the end of 2009 and March 2020.
Intended first-line treatment included pre- and postoperative chemotherapy according to the PKUPH-OS protocol , as well as surgery of all operable lesions.
All protocols prescribed high-dose methotrexate, doxorubicin, cisplatin and ifosfamide in varying combinations.
Description
Inclusion Criteria:
- Histologically confirmed high-grade osteosarcoma reviewed by the Pathology Committee of Peking University People's Hospital
- Pulmonary nodules by Chest CT confirmed by later scan as pulmonary metastasis
- A first complete remission (CR) had been achieved
- Intended first-line treatment included pre- and postoperative chemotherapy according to the PKUPH-OS protocol as well as local therapy of all operable lesions
Exclusion Criteria:
- Lost to follow up
- Patients with severe or uncontrolled medical disorders that could jeopardize the outcomes of the study. These confounding conditions included, cardiac clinical symptoms or disease with left ventricular ejection fraction<50%, and hypertension that could not be well controlled with antihypertensive drugs.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
osteosarcoma patients receiving resections
|
patients received VATS
|
osteosarcoma patients receiving radiotherapy
|
patients received radiotherapy
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
event-free survival
Time Frame: 2 year
|
from local therapy of the pulmonary nodules to any events of progression of disease/last follow-up
|
2 year
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
local recurrence rate
Time Frame: 2 year
|
from local therapy of the pulmonary nodules to local recurrence/last follow-up
|
2 year
|
overall survival
Time Frame: 5 year
|
from local therapy of the pulmonary nodules to death/last follow-up
|
5 year
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Collaborators
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (ACTUAL)
January 1, 2020
Primary Completion (ACTUAL)
October 1, 2020
Study Completion (ACTUAL)
November 1, 2020
Study Registration Dates
First Submitted
September 4, 2020
First Submitted That Met QC Criteria
September 6, 2020
First Posted (ACTUAL)
September 11, 2020
Study Record Updates
Last Update Posted (ACTUAL)
December 4, 2020
Last Update Submitted That Met QC Criteria
December 3, 2020
Last Verified
December 1, 2020
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- PKUPH-sarcoma 13
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
NO
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
product manufactured in and exported from the U.S.
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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