The Effect of Soluble Fiber Dextrin on Subjective and Physiological Markers of Appetite

The Effect of Soluble Fiber Dextrin on Subjective and Physiological Markers of Appetite: a Randomized Trial

This study examines the effect of soluble fiber dextrin on food intake, appetite, and physiological markers of appetite. Adults aged 18-45 years with a BMI were recruited for this study. Participants were given two doses of SFD in the morning and appetite, food intake and physiological markers of appetite were measured over 10 years.

Study Overview

• Status: Completed
• Conditions: Appetitive Behavior
• Intervention / Treatment: Other: Soluble Fiber Dextrin

Detailed Description

Overweight and obesity are leading health problems. The study investigates the effect of a food ingredient from two different sources at two different doses on food intake and appetite markers over a 10 hour period. All participants reported to the laboratory first thing in the morning and remained in the laboratory until after their evening meal. A fixed breakfast was served but the participants were free to eat as much as they liked at lunch and dinner. Blood was taken at regular intervals during the day and assayed for glucose and several hormones related to appetite. Subjective measures of appetite were also collected over the 10 hour test session.

• Study Type: Interventional
• Enrollment (Actual): 50
• Phase: Not Applicable

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 45 years (Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

Description

Inclusion Criteria:

BMI 19.9 - 29.9 Aged 18-45 Find the study foods to be palatable

Exclusion Criteria:

Weight change > 3kg in the past three months Do not regularly consume snacks Presence or history of GI disorders Restrained eater Used medication that influences appetite

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: Randomized
• Interventional Model: Crossover Assignment
• Masking: Double

Number of Arms

5

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Placebo Comparator: Control; Maltodextrin	Other: Soluble Fiber Dextrin; Ingredient based on resistant starch
Experimental: SFD Tapioca 20g; 20g soluble fiber dextrin derived from tapioca	Other: Soluble Fiber Dextrin; Ingredient based on resistant starch
Experimental: SFD Tapioca 40g; 40g soluble fiber dextrin derived from tapioca	Other: Soluble Fiber Dextrin; Ingredient based on resistant starch
Experimental: SFD corn 20g; 40g soluble fiber dextrin derived from corn	Other: Soluble Fiber Dextrin; Ingredient based on resistant starch
Experimental: SFD corn 40g	Other: Soluble Fiber Dextrin; Ingredient based on resistant starch

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Food intake	Food intake measured at lunch and evening meal.	10 hours

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Appetite	Subjective appetite measures using questionnaires at regular intervals over 10 hours,	10 hours
CCK	Plasma CCK measured at regular intervals over 10 hours.	10 hours
GLP-1	Plasma GLP-1 measured at regular intervals over 10 hours.	10 hours
PYY3-36	Plasma PYY3-36 measured at regular intervals over 10 hours.	10 hours
Breath Hydrogen	Breath hydrogen measured at regular intervals over 10 hours.	10 hours

Collaborators and Investigators

• Sponsor: Iowa State University

Study record dates

Study Major Dates

• Study Start (Actual): January 1, 2014
• Primary Completion (Actual): January 1, 2017
• Study Completion (Actual): January 1, 2018

Study Registration Dates

• First Submitted: October 15, 2020
• First Submitted That Met QC Criteria: October 15, 2020
• First Posted (Actual): October 22, 2020

Study Record Updates

• Last Update Posted (Actual): October 22, 2020
• Last Update Submitted That Met QC Criteria: October 15, 2020
• Last Verified: September 1, 2020

More Information

Terms related to this study

• Other Study ID Numbers: SFDISU

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No