COVID-19 and Acute Invasive Fungal Rhinosinusitis

The Impact of COVID-19 Outbreak on The Incidence of Acute Invasive Fungal Rhinosinusitis

Data for acute invasive rhinosinusitis was obtained from the Otorhinolaryngology departments at our tertiary hospital at the period from January 2017 to December 2020. Then the risk factors of comorbid diseases and fungal types between post-Covid-19 and non-Covid-19 groups regarding the incidence of invasive rhinosinusitis are compared.

Study Overview

• Status: Completed
• Conditions: Covid19
• Intervention / Treatment: Diagnostic test: Fungal rhinosinusitis

• Study Type: Observational
• Enrollment (Actual): 56

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 15 years to 90 years (Child, Adult, Older Adult)
• Accepts Healthy Volunteers: N/A
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Patients of any age and sex medically managed in AlAzhar Hospitals in Egypt for invasive rhinosinusoitis

Description

Inclusion Criteria:

• Patients of any age and sex. invasive rhinosinusoitis diagnosis based on clinical , endoscopic diagnosis
• Positive findings for acute sinusitis on sinus computed tomography (CT) scan in addition to fungal determination by histopathological examination of specimen of affected tissues for detection of the type of fungi.
• Positive PCR was confirmed from the patient's files at the isolation hospitals for COVID 19 group.

Exclusion Criteria:

• Patients who completed management outside our hospital

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Non-COVID19 patients; All acute invasive fungal rhinosinusitis patients managed in our hospital from January 2017 up to February 2020	Diagnostic test: Fungal rhinosinusitis; Pathology examination
COVID19 patients; All acute invasive fungal rhinosinusitis patients managed in our hospital from February 2020 up to December 2020 with positive COVID19 PCR test	Diagnostic test: Fungal rhinosinusitis; Pathology examination

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Fungus detection	Culture and microscopic examination by the light microscope to examine the different types of the fungi using hematoxylin & eosin stain and Periodic acid-Schiff stain which is positive in fungi	2 weeks

Collaborators and Investigators

• Sponsor: Al-Azhar University

Study record dates

Study Major Dates

• Study Start (Actual): January 1, 2017
• Primary Completion (Actual): December 31, 2020
• Study Completion (Actual): December 31, 2020

Study Registration Dates

• First Submitted: March 19, 2021
• First Submitted That Met QC Criteria: March 19, 2021
• First Posted (Actual): March 22, 2021

Study Record Updates

• Last Update Posted (Actual): March 22, 2021
• Last Update Submitted That Met QC Criteria: March 19, 2021
• Last Verified: March 1, 2021

More Information

Terms related to this study

• Keywords: rhinosinusitis; fungal sinusitis
• Additional Relevant MeSH Terms: Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Virus Diseases; Infections; Respiratory Tract Infections; Respiratory Tract Diseases; Pneumonia, Viral; Pneumonia; Lung Diseases; COVID-19
• Other Study ID Numbers: 20- 11- 002

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED
• IPD Plan Description: publication in medical journal

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No