Calorimetry Guided Nutrition vs. Recommended Daily Intake in Weaning Chronically Ventilated Patients: Double Blind RCT.

A Randomized Controlled Trial to Examine the Efficacy of a Calorimetry Guided Nutritional Plan vs. the Recommended Daily Intake Guided Nutritional Plan in Weaning Chronically Ventilated Patients

In this study, we intend to examine the effectiveness of an indirect calorimetry-guided nutrition plan, compared to the conventional, RDI-guided nutrition plan in mechanically ventilated patients, in terms of success rates of prolonged ventilation weaning, and shorter weaning time period.

Hypotheses: The rates of chronically ventilated patients weaned off invasive ventilation will increase by 15% in the intervention group, and the average weaning period in this group will be reduced by 10 ± 4 days.

Methods: A randomized controlled intervention trial that will include 200 chronically ventilated patients, admitted to the "Reuth" Rehabilitation Hospital, who meet the criteria for weaning from prolonged mechanical ventilation. Patients in the intervention group (n=100) will undergo precise calorimetric measurements using indirect calorimetry and will be administered with a nutrition plan in accordance with these measurements. Nutrition plans of patients in the control group (n=100) will be calculated and administered according to current RDI conventions (up to 24 Kcal/kg/day). In order to assure blinding, patients in the control group will undergo the same calorimetric measurements using indirect calorimetry, however, these results will not be used in any way to determine or influence the nutritional plan.

Study Overview

• Status: Active, not recruiting
• Conditions: Mechanical Ventilation
• Intervention / Treatment: Other: Nutrition and fluid plans prepared using calorimetry-based measurements.

Detailed Description

Background: The number of patients in need of prolonged mechanical ventilation as means of life support is rapidly growing due to advancements in life-saving medical care for critically ill patients, an aging population, and the expanding use of aggressive surgical treatments. Both overfeeding and underfeeding are found to negatively affect the weaning process from mechanical ventilation. The caloric demands of chronically ventilated patients are reduced due to immobility and minimal energy requirements. Nowadays, nutrition plans are determined using the RDI (recommended dietary intake) formula, according to a patient's own weight and height. The RDI formula does not take into account the negligible activity levels of chronically ventilated patients or their deteriorating muscle mass, which is severely reduced due to prolonged periods of inactivity. This, in turn, may lead to increased body fat mass and fluid retention - which are both deleterious to the patients' health and may hinder their weaning from prolonged mechanical ventilation. Calorimetry is an accurate tool for measuring energy expenditures allowing us to assess the actual energy requirements of every patient. In indirect calorimetry, measurements of gas exchange are used to determine oxygen consumption versus the production and release of carbon dioxide. The "Reuth" Rehabilitation Hospital houses 108 chronically ventilated adult patients at a given moment, with turnover rates of 70-80 patients per year. If possible, these patients eventually undergo ventilation weaning. The current success rate for ventilation weaning reaches 55%, with a total duration of approximately two months.

Aim: To increase the success rates of prolonged ventilation weaning, i.e achieve a higher percentage of patients who successfully undergo mechanical ventilation weaning, with a shorter overall weaning time.

Hypotheses: The rates of chronically ventilated patients weaned off invasive ventilation will increase to 70% in the intervention group, and the average weaning period will be reduced by 10 ± 4 days.

Methods: A randomized controlled intervention trial that will include 200 chronically ventilated patients admitted to the "Reuth" Rehabilitation Hospital, who meet the criteria for weaning from prolonged mechanical ventilation. Patients in the intervention group (n=100) will undergo precise calorimetric measurements using indirect calorimetry and will be administered with a nutrition plan in accordance with these measurements. Nutrition plans of patients in the control group (n=100) will be calculated and administered according to current RDI conventions (up to 24 Kcal/kg/day). In order to assure blinding, patients in the control group will undergo the same calorimetric measurements using indirect calorimetry, however, these results will not be used in any way to determine or influence the nutritional plan.

Significance: In the United States, the use of prolonged mechanical ventilation increases by 5.5% annually, while total admissions rates increase by just 1% per year. According to estimates, the total number of patients requiring prolonged mechanical ventilation will be doubled by 2020, reaching 305,898 cases. It is safe to assume that similar trends exist in Israel, where 635 hospital beds are allocated to the ventilated patients. The total monthly admission costs for every ventilated patient in Israel are estimated at 14,140 USD, reaching nine million USD a year. Prolonged mechanical ventilation has a negative impact on both the patient and his family while caring for ventilated patients imposes a heavy burden on the health care system. In this study, we strive to increase the success rates of prolonged ventilation weaning, thereby improving ventilated patients' outcomes and alleviating the hardships inflicted on the patients, their families, and the health care system as a whole.

• Study Type: Interventional
• Enrollment (Estimated): 200
• Phase: Not Applicable

Contacts and Locations

• Study Contact: Name: Maya Elyashiv, MD; Phone Number: +972 (0) 36893710; Email: maya.elyashiv@reuth.org.il
• Study Contact Backup: Name: Mila Fradkin, MPH; Phone Number: +972 (0) 527360561; Email: mila.fradkin@gmail.com

Study Locations

• Israel
  • Tel Aviv, Israel
    • Reuth Rehabilitation Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria:

1. Newly admitted prolonged mechanical ventilation patients on tracheostomy tube ventilation (over 21 days, a minimum of 6 hours a day);
2. Over 18 years of age;
3. PEEP below 8 cm H2O;
4. FiO2 below 60%;

5. Hemodynamically stable:

   • Alert and oriented (does not apply to patients in a vegetative state);
   • Blood pressure at or above 80/50 mmHg;
   • Body temperature - normal around 36.6°C;
   • Heart rate - 40-140 beats per minute;
   • Breath - 10-20 breaths per minute;
6. No active infection (clinically stable patients receiving antibiotic treatment for more than 48 hours following an acute infection may be enrolled in the trial);

Exclusion Criteria:

1. Ventilated patients with PEEP values exceeding 8 cmH2O, which mandates the use of FiO2 values over 60%;

2. Hemodynamically unstable patients:

   • Blood pressure below 80/50 mmHg;
   • Over 140 beats per minute, or less than 40 beats per minute in symptomatic patients;
   • Newly diagnosed fever (over 38.0°C);
3. Patients receiving antibiotics for an active infection, under 48 hours.
4. Blood pH values below 7.3 due to metabolic abnormality;
5. Patients with irreversible advanced musculoskeletal neurodegenerative disorders.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Supportive Care
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Triple

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Intervention group; Patients in this group will be administered nutrition and fluid plans prepared by the department dietitian using calorimetry-based measurements	Other: Nutrition and fluid plans prepared using calorimetry-based measurements.; Nutrition and fluid plans prepared using calorimetry-based measurements.
No Intervention: Control group; Nutrition plans of patients in this group will be calculated by the department dietitian using the standard, currently accepted RDI (recommended dietary intake) formula.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Successful weaning	Rate of successful weaning, i.e. a number of patients successfully weaned from prolonged mechanical ventilation, out of those who underwent weaning attempts.	Within 8 weeks
Time to successful weaning	Time period in days from randomization to one of the studies groups and until successful weaning or 5 failed consecutive weaning attempts.	Within 8 weeks

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Discharge destination following successful weaning	Discharge destination (other department, other hospital, home, nursing home)	Within 8 weeks
Three months survival rates post-weaning	Three months survival rates of patients who underwent successful weaning from mechanical ventilation.	3 months

Other Outcome Measures

Outcome Measure	Measure Description	Time Frame
Twelve months survival rates post-weaning	Twelve months survival rates of patients who underwent successful weaning from mechanical ventilation.	12 months

Collaborators and Investigators

• Sponsor: Reuth Rehabilitation Hospital

Study record dates

Study Major Dates

• Study Start (Actual): December 1, 2019
• Primary Completion (Estimated): July 1, 2023
• Study Completion (Estimated): December 31, 2024

Study Registration Dates

• First Submitted: March 15, 2021
• First Submitted That Met QC Criteria: March 29, 2021
• First Posted (Actual): April 1, 2021

Study Record Updates

• Last Update Posted (Actual): July 11, 2023
• Last Update Submitted That Met QC Criteria: July 10, 2023
• Last Verified: July 1, 2023

More Information

Terms related to this study

• Keywords: Nutrition; Weaning; Mechanical Ventilation
• Other Study ID Numbers: 0014-18-RRH

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No