Postoperative Analgesic Benefit of iPACK Block in the Anterior Cruciate Ligament Reconstruction Surgery (Liga-PACK)

March 4, 2026 updated by: University Hospital, Toulouse

Postoperative Analgesic Benefit of iPACK Block in the Anterior Cruciate Ligament Reconstruction Surgery, the LIGA-PACK Study

This randomised clinical trial evaluates the analgesia provided by an iPack block associated with an adductor canal block in patients who undergo anterior cruciate ligament reconstruction surgery, compared to an adductor canal block alone. The objective is to prove the superiority of this locoregional anesthesia in terms of analgesia and functional rehabilitation.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

The ideal loco-regional anesthesia for anterior cruciate ligament reconstruction ensuring a satisfying analgesia without compromising an early rehabilitation is still undetermined.

Femoral nerve block has been incriminated in a delayed postoperative mobilization whereas the adductor canal block gives an equivalent analgesia for a better preservation of the quadricipital muscular strength.

The iPACK block (infiltration between the popliteal artery and the capsule of the posterior knee) is a recently described technique. Few studies have assessed the iPACK block in ACL reconstruction, and none were randomized.

This randomized single blind clinical trial compares two groups of 45 patients who undergo ACL reconstruction surgery under general anaesthetic : one receives an iPACK block associated with an adductor canal block, and the other only has an adductor canal block.

Pain scores and opioid consumption are collected after surgery in the recovery room, then by telephone interview at 24 and 48 hours post-surgery. Functional rehabilitation is evaluated by scales (KOOS, LYSHOLM and iKDC) at 3, 6 and 9 months after surgery. Adverse effects, due to anesthesia or opioids, are collected from 30 min after loco-regional anesthesia until the second phone call at 48h post-surgery.

Study Type

Interventional

Enrollment (Actual)

90

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • France
      • Toulouse, France
        • University Hospital of Toulouse

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • Age ≥ 18 years
  • ACL repair surgery under general anesthesia
  • Person affiliated or beneficiary of a social security plan
  • Free, informed and written consent

Exclusion Criteria:

  • Age < 18 years
  • Contraindication to ALR (allergy to local anesthetics, local infection of the puncture site, coagulopathy)
  • Pre-existing opiate dependence
  • Contraindication to non-steroidal anti-inflammatory drugs
  • Pregnant or potentially pregnant women
  • Patients under the protection of adults (guardianship, curatorship or safeguard of justice)
  • Patients whose cognitive state does not allow evaluation by the scales used

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Single

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Active Comparator: adductor canal block
loco-regional analgesia with adductor canal block (ACB) method (for anterior cruciate ligament reconstruction )
Procedure: adductor canal block
loco-regional anesthesia using adductor canal block
Other Names:
  • ACB
Experimental: iPACK block
loco-regional analgesia with iPACK block (infiltration between the popliteal artery and the capsule of the posterior knee) ((for anterior cruciate ligament reconstruction )
Procedure: iPACK block
loco-regional anesthesia using infiltration between the popliteal artery and the capsule of the posterior knee

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Cumulative opioid consumption at 48 hours after surgery
Time Frame: Hours 48
Cumulative opioid consumption in the first 48 hours after anterior cruciate ligament repair surgery
Hours 48

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Cumulative opioid consumption at 2 hours after surgery
Time Frame: Hours 2
Cumulative opioid consumption in the recovery room after anterior cruciate ligament repair surgery
Hours 2
Cumulative opioid consumption at 24 hours after surgery
Time Frame: Hours 24
Cumulative opioid consumption in the first 24 hours after anterior cruciate ligament repair surgery
Hours 24
Cumulative opioid consumption at 3 months
Time Frame: month 3
total opioid consumption at 3 months after anterior cruciate ligament repair surgery
month 3
Maximum pain score in the recovery room
Time Frame: hours 2
Maximum pain score evaluated by the numerical pain scale from 0 to 10 (0 lowest pain score / 10 highest pain score)
hours 2
Maximum pain score at 24 hours after surgery
Time Frame: hours 24
Maximum pain score evaluated by the numerical pain scale from 0 to 10 (0 lowest pain score / 10 highest pain score)
hours 24
Maximum pain score at 48 hours after surgery
Time Frame: hours 48
Maximum pain score evaluated by the numerical pain scale from 0 to 10 (0 lowest pain score / 10 highest pain score)
hours 48

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University Hospital, Toulouse

Investigators

  • Principal Investigator: Fabrice FERRE, MD, University Hospital, Toulouse

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

December 13, 2021

Primary Completion (Actual)

June 30, 2023

Study Completion (Actual)

December 31, 2023

Study Registration Dates

First Submitted

October 20, 2021

First Submitted That Met QC Criteria

November 15, 2021

First Posted (Actual)

November 29, 2021

Study Record Updates

Last Update Posted (Actual)

March 6, 2026

Last Update Submitted That Met QC Criteria

March 4, 2026

Last Verified

March 1, 2026

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • RC31/21/0167
  • 2021-A01226-35 (Other Identifier: ID-RCB)

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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