Evaluation of Non-Compressive Myelopathy in a Sample of Egyptian Patients

An observational study will be conducted in the Department of Neurology at AlAzhar University Hospitals To study the etiological factors of non-compressive myelopathy in a sample of Egyptian patients

Study Overview

• Status: Recruiting
• Conditions: Myelopathy; Non-Compressive
• Intervention / Treatment: Diagnostic test: CSF Examination

Detailed Description

Myelopathy is a collective term referring to any pathologic condition or neurologic deficit related to the spinal cord. Myelopathies are a frequent and potentially disabling neurologic emergency.(Sarbu et al., 2019).

Diseases of the spinal cord often have devastating consequences and imaging studies are indispensable for their diagnosis. The diagnostic approach must be based on the clinical context, the time elapsed since the onset of symptoms and signs, and the imaging findings (Herrera et al., 2020).

Myelopathies may be compressive or non-compressive, regarding to subarachnoid space obstruction (Kundu et al., 2018).

Noncompressive myelopathy (NCM) is described as "spinal cord involvement without detectable clinical and radiological evidence of spinal cord compression causing neurological deficit (Thangaraj et al., 2019).

There have been a few studies that have investigated Noncompressive myelopathy (NCM) in Africa as part of nontraumatic myelopathy. With very few studies focusing on NMOSD, Most of them focus on extrinsic compression and infectious diseases as important causes of myelopathy (Musubire et al., 2021) Comprehensive data on Egyptian patients with Non-compressive myelopathy (NCM) in the light of newer diagnostic criteria and serological tests are lacking. No study has been conducted to study the clinico-radiological profile of Non-compressive myelopathy (NCM) so far. In this study, we are putting an effort to convey our experience on etiological pattern of Non-compressive myelopathy (NCM) with special reference to its radiological features.

• Study Type: Observational
• Enrollment (Anticipated): 50

Contacts and Locations

• Study Contact: Name: Islam S Al-Emam, MSC; Phone Number: +201027759946; Email: eslamsalman211@gmail.com
• Study Contact Backup: Name: Abdel-Ghaffar Iٍ Fayed, Lecturer; Phone Number: +20 111 870 6806; Email: drfayed1984@azhar.edu.eg

Study Locations

• Egypt
  • Cairo, Egypt
    • Recruiting
    • Al-Hussein and Sayed Galal Hospitals
    • Contact: Mohie-eldin T Mohamed, Professor; Phone Number: +20 115 736 3721; Email: mohie-eldin@azhar.edu.eg

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 2 months to 100 years (ADULT, OLDER_ADULT, CHILD)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Patients with acute, subacute, or chronic neurologic dysfunction consistent with myelopathy

Description

Inclusion Criteria:

- Patients with acute, subacute, or chronic neurologic dysfunction (motor and sensory deficit, sphincteric involvement, and a well-defined upper sensory segmental level) consistent with myelopathy (with or without coexisting encephalopathy, neuropathy, or radiculopathy).

Exclusion Criteria:

• 1) Patients of myelopathy who did not undergo magnetic resonance imaging (MRI) of the spinal cord. 2) Spinal cord compression on MRI explaining patient's neurologic dysfunction. 3) History of previous trauma, acute coma and patients with definite cerebral symptoms incompatible with spinal pathology (e.g., aphasia, hemianopia, neglect, facial involvement). 4) Motor neuron disease (MND) 5)Degenerative ataxias.

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
To study the etiological factors of non-compressive myelopathy in a sample of Egyptian patients	study the clinico-radiological profile of Non-compressive myelopathy	6 months

Collaborators and Investigators

• Sponsor: Al-Azhar University
• Investigators: Principal Investigator: Mohie-eldin T Mohamed, Professor, Al-Azhar Faculty of Medicine

Study record dates

Study Major Dates

• Study Start (ACTUAL): January 1, 2022
• Primary Completion (ANTICIPATED): June 30, 2022
• Study Completion (ANTICIPATED): July 31, 2022

Study Registration Dates

• First Submitted: February 17, 2022
• First Submitted That Met QC Criteria: February 17, 2022
• First Posted (ACTUAL): February 25, 2022

Study Record Updates

• Last Update Posted (ACTUAL): February 25, 2022
• Last Update Submitted That Met QC Criteria: February 17, 2022
• Last Verified: February 1, 2022

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Central Nervous System Diseases; Nervous System Diseases; Hematologic Diseases; Spinal Cord Diseases; Bone Marrow Diseases
• Other Study ID Numbers: 0000044

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED
• IPD Plan Description: To study the etiological factors of Non-compressive Myelopathy in a sample of Egyptian patients

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No