- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05281315
Cardiac Magnetic Resonance Features and Outcomes of Patients With Non-Compaction Cardiomyopathy - a Retrospective Follow-up From Pakistan
Study Overview
Status
Conditions
Detailed Description
Left Ventricle Non-Compaction Cardiomyopathy (LVNCC) is a type of myocardial disease characterized by prominent myocardial trabeculae and recesses resulting in two distinct layers of myocardium: compacted layer and the non-compacted layer. It arises due to the failure of left ventricle (LV) maturation and compaction during intra-uterine life (1). As per the position statement from the European Society of Cardiology, LVNCC has been labelled as 'unclassified' type of cardiomyopathy. Clinical course can be complicated by heart failure, thromboembolism, or arrhythmia.
Phenotypic presentation of LVNC can range from extremely thickened layer of non-compacted myocardium to mere presence of prominent trabeculae and recesses albeit a compacted myocardium. Transthoracic echocardiography is the first tool to diagnose LVNC. However, Cardiac Magnetic Resonance (CMR) imaging has emerged as a strong tool to differentiate between LVNCC from mere hyper-trabeculated LV myocardium when echocardiogram is inconclusive (Figure 1 and Video 1). Various criteria have evolved to diagnose LVNC by CMR. Peterson et al defined the end-diastole non-compacted to compacted myocardium ratio of >2.3 to have good sensitivity, specificity, and negative predictive value for differentiating pathological non-compaction from hyper-trabeculation.
With an increase in the use of diagnostic cardiovascular imaging modalities in South-Asian (SA) belt, LVNC is being increasingly diagnosed. The exact prevalence of LVNC in SA is not known and phenotypic CMR characteristics, clinical features, and outcomes of LVNC remain unknown for SA population. This brought us to the need of analysing CMR data of LVNC at our centre.
Study Type
Enrollment (Actual)
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
- Patients > 18 years, referred for CMR for further evaluation of cardiomyopathy.
Exclusion Criteria:
- patients with intracardiac masses, pericardial diseases and congenital heart diseases were excluded from the study.
Study Plan
How is the study designed?
Design Details
- Observational Models: Cohort
- Time Perspectives: Retrospective
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
To evaluate clinical characteristics, cardiac magnetic resonance imaging features, and outcomes of patients with left ventricle non-compaction.
Time Frame: 37 months
|
Evaluating CMR features and looking at outcomes such as all cause mortality, major heart failure or arrhythmia hospitalizations.
|
37 months
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
All cause-mortality, heart failure hospitalization, and arrhythmia hospitalization.
Time Frame: 37 months
|
All cause-mortality, heart failure hospitalization, and arrhythmia hospitalization.
|
37 months
|
Collaborators and Investigators
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 2020-5594-14863
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
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Clinical Trials on Left Ventricle Non-compaction Cardiomyopathy
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University of LeipzigCompletedLeft Ventricular Hypertrophy | Left Ventricular Failure | Left Ventricular Non-compaction CardiomyopathyGermany
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Assistance Publique Hopitaux De MarseilleCompletedLeft Ventricular Non CompactionFrance
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Indiana UniversityAmerican Heart AssociationRecruitingCardiomyopathies | Dilated Cardiomyopathy | Hypertrophic Cardiomyopathy | Arrhythmogenic Right Ventricular Cardiomyopathy | Restrictive Cardiomyopathy | Left Ventricular Non-compaction CardiomyopathyUnited States
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Lawson Health Research InstituteRecruiting
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Stanford UniversityUniversity of Pennsylvania; The Cleveland Clinic; Erasmus Medical Center; Seoul...RecruitingNon-Compaction CardiomyopathyUnited States, Korea, Republic of, Netherlands
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Tomsk National Research Medical Center of the Russian...RecruitingHeart Failure | Left Bundle-Branch Block | Ischemic Cardiomyopathy | Left Ventricular Dysfunction | Left Ventricular Dyssynchrony | Non-ischemic Dilated Cardiomyopathy | Left Ventricle RemodelingRussian Federation
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Tomsk National Research Medical Center of the Russian...Not yet recruitingHeart Failure | Left Bundle-Branch Block | Ischemic Cardiomyopathy | Left Ventricular Dysfunction | Non-ischemic Dilated Cardiomyopathy | Left Ventricle RemodelingRussian Federation
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Beijing Institute of Heart, Lung and Blood Vessel...UnknownDilated Cardiomyopathy | Hypertrophic Cardiomyopathy | Arrhythmogenic Right Ventricular Cardiomyopathy | Restrictive Cardiomyopathy | Left Ventricular Non-compactionChina
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Beijing Institute of Heart, Lung and Blood Vessel...Beijing Anzhen Hospital; Chinese Academy of Medical Sciences, Fuwai HospitalUnknownDilated Cardiomyopathy | Hypertrophic Cardiomyopathy | Arrhythmogenic Right Ventricular Cardiomyopathy | Restrictive Cardiomyopathy | Left Ventricular Non-compactionChina
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University of GroningenUnknownDouble Inlet Left Ventricle
Clinical Trials on Patients were retrospectively enrolled. This was a retrospective study and no intervention was performed.
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Huazhong University of Science and TechnologyRecruitingBladder Cancer | Non-Muscle-Invasive Bladder CancerChina
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Aga Khan University Hospital, PakistanCompleted
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Shanghai Tongji Hospital, Tongji University School...Huashan HospitalCompleted
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First Affiliated Hospital Xi'an Jiaotong UniversityCompletedAcute Aortic DissectionChina
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Boston IVFCompleted
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First Affiliated Hospital Xi'an Jiaotong UniversityCompletedPulmonary Hypertension | Acute Myocardial InfarctionChina
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Zhejiang Cancer HospitalCompletedBreast Cancer | PI3K/AKT/mTOR Pathway Mutation | EverolimusChina
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Shenzhen Center for Disease Control and PreventionCompletedPuberty, Precocious
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Xijing HospitalRecruiting
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Qianfoshan HospitalNot yet recruiting