CLIC1 in Patients Presenting PD

Accumulation of Chloride Intracellular Channel 1 (CLIC1) Protein in Circulating Monocyte in Elderly Patients Presenting Postoperative Delirium and Its Predictable Role of Postoperative Delirium

In this study, mononuclear cells, particularly monocytes, were collected from the peripheral blood of elderly patients who underwent orthopedic hip surgery under spinal anesthesia. We then observe the accumulation of chloride intracellular channel 1 (CLIC1), particularly the characteristic accumulation morphology and its function. The purpose of this study is to compare whether there is a difference in the degree and form of cytoplasmic CLIC1 accumulation between the elderly group with postoperative delirium (PD) and the elderly group without postoperative delirium. We'll also confirm whether this is appropriate as a predictor of postoperative delirium. In addition, we will establish a control group for the non-elderly group to check the difference due to aging itself.

Study Overview

• Status: Recruiting
• Conditions: Hip Fractures; Hip Disease
• Intervention / Treatment: Behavioral: Postoperative delirium; Procedure: Hip surgery

• Study Type: Observational
• Enrollment (Anticipated): 90

Contacts and Locations

• Study Contact: Name: Hyo-Seok Na; Phone Number: 821087012913; Email: hsknana@naver.com

Study Locations

• Korea, Republic of
  • Gyeonggi
    • Seongnam, Gyeonggi, Korea, Republic of, 463-707
      • Recruiting
      • Seoul National Univ. Bundang Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 20 years and older (ADULT, OLDER_ADULT)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Probability Sample

Study Population

Patients undergoing hip joint surgery are divided into the old group and the young group.

The old group is further divided into the old with PD group and the old without PD.

Description

Inclusion Criteria:

• Old group: Male or female patients aged 65 years or older who are scheduled to undergo surgery for an orthopedic hip fracture under spinal anesthesia
• Young group: Male or female patients between 20 and 50 years of age who are scheduled to undergo orthopedic hip joint surgery under spinal anesthesia

Exclusion Criteria:

• Patients who are unconscious
• Patients who are unable to communicate

Study Plan

How is the study designed?

Number of groups / cohorts

3

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Old with postoperative delirium	Behavioral: Postoperative delirium; Postoperative delirium; Procedure: Hip surgery; Orthopedic hip joint surgery under spinal anesthesia
Old without postoperative delirium	Procedure: Hip surgery; Orthopedic hip joint surgery under spinal anesthesia
Young	Procedure: Hip surgery; Orthopedic hip joint surgery under spinal anesthesia

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
expression pattern of CLIC1 protein	Immediate after spinal anesthesia

Collaborators and Investigators

• Sponsor: Seoul National University Bundang Hospital

Study record dates

Study Major Dates

• Study Start (ACTUAL): June 27, 2022
• Primary Completion (ANTICIPATED): June 30, 2023
• Study Completion (ANTICIPATED): June 30, 2023

Study Registration Dates

• First Submitted: July 1, 2022
• First Submitted That Met QC Criteria: July 1, 2022
• First Posted (ACTUAL): July 6, 2022

Study Record Updates

• Last Update Posted (ACTUAL): August 3, 2022
• Last Update Submitted That Met QC Criteria: August 1, 2022
• Last Verified: August 1, 2022

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Fractures, Bone; Wounds and Injuries; Leg Injuries; Femoral Fractures; Hip Injuries; Hip Fractures
• Other Study ID Numbers: B-2109-706-302

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No