- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05779319
1000 Eyes Lens Biometry Study: Artificial Intelligence for Intraocular Lens Power Calculation
The 1000 Eyes Lens Power Trial: Introducing Artificial Intelligence to Intraocular Lens Power Calculation
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Cataract surgery is one of the most commonly performed surgeries worldwide and has a high postoperative patient satisfaction rate. Despite significant improvement in measurement methods and artificial lens power calculation formulas, miscalculations and subsequently refractive error still occur after cataract surgery.
Most current artificial lens calculation methods use regression formulas. The concept of artificial intelligence (AI) has only recently found use and only in a rudimentary way. Examples include the Hill-RBF calculator and the Ladas superformula, but at least the "superformula" does not use a true AI approach and the results are no better than those obtained with conventional methods.
The main purpose of the study is to develop an AI approach to improve intraocular lens power calculations. The data will be used for the following analysis:
- To compare the new AI method with conventional and modern formula (main question)
- To compare the refractive error for different eye lengths
- To use a ray tracing method to quantify sources of error in patients with a refractive surprise of at least 1.0 diopter
- To evaluate a novel concept of outlier testing using a modified nonparametric Walsh test
This study will be multi-center and partially prospective. Data from 1000 patients who have already had cataract surgery will be analyzed.
All patients will be invited for a visit to the recruitment clinic and the measurements will be performed.
Study Type
Enrollment (Estimated)
Contacts and Locations
Study Contact
- Name: Nino Hirnschall, MD
- Phone Number: 73411 +435768083
- Email: nino.hirnschall@kepleruniklinikum.at
Study Contact Backup
- Name: Matthias Bolz, MD
- Phone Number: 78409 +435768083
- Email: matthias.bolz@kepleruniklinikum.at
Study Locations
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Upperaustria
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Linz, Upperaustria, Austria, 4020
- Recruiting
- Kepler University Klinik Departement of Opthalmology
-
Contact:
- Leon U Pomberger, Dr.
- Phone Number: +496645891357
- Email: leon.pomberger@kepleruniklinikum.at
-
Contact:
- Nino U Hirnschall, Dr.
- Email: nino.hirnschall@kepleruniklinikum.at
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Sampling Method
Study Population
Description
Inclusion Criteria:
- Pseudophakic (at least one eye): cataract surgery between 4 weeks and 24 months prior to recruitment
- If both eyes would be suitable for the study only the right eye will be included, if only one eye is suitable for the study, this eye will be included
- Pre-operative swept-source OCT biometry available (no ultrasound measurement for axial eye length)
- Uncomplicated cataract surgery
- Age 21 years and older
Exclusion Criteria:
- Multifocal IOLs
- Combined surgery (cataract plus glaucoma/vitreoretinal/corneal surgery)
- Best corrected distance visual acuity below 0.5 Snellen
- In case of pregnancy (pregnancy test will be taken preoperatively in women of reproductive age)
Study Plan
How is the study designed?
Design Details
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
a new artificial intelligence based approach for intraocular lens power calculation
Time Frame: 2 years
|
Developing an artificial intelligence algorithm to predict post-operative refraction
|
2 years
|
Collaborators and Investigators
Investigators
- Principal Investigator: Nino Hirnschall, MD, JKU Linz
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- KUK-Opthalmology-013
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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