- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05806606
Effect and Cost Effectiveness of a Dyadic Empowerment-based Heart Failure Management Program for Self-care
The Effects and Cost-effectiveness of a Dyadic Empowerment-based Heart Failure Management Program (De-HF) on Self-care, HRQL and Hospital Readmission: A Randomized Controlled Trial
Global population aging has drastically increased healthcare spending worldwide, with the greatest portion going to hospital and community health services. Heart failure (HF), as the final form of many cardiovascular diseases resulting from insufficient myocardial pumping. Ineffective self-care is consistently identified as the major modifiable risk factor for HF decompensation requiring hospitalization. It refers to an active cognitive process that influence patients' engagement in self-care maintenance, symptom perception and self-care management. However, current studies pay much focus on interventions such as motivational interviewing and behavioural activation to enhance the HF-related self-care and health outcomes which only produces short-term benefits. In fact, the lack of a sustainable effect from the self-care supportive interventions might be related the use of patient-centric design in these studies, which totally ignores the fact that HF management takes place in a dyadic context. To advance, active strategies were adopted to mobilize collaborative effort of the dyad in actual disease management.
This study aims to evaluate the effects and cost-effectiveness of a Dyadic empowerment-based Heart Failure Management Program (De-HF) for self-care, health outcomes, and health service utilization among HF patients who require family support after hospital discharge. The De-HF program is based on the Theory of Dyadic Illness Management to enhance the congruence in illness perception and active dyadic collaboration in managing HF via both face-to-face and online platforms.
Study Overview
Status
Intervention / Treatment
Detailed Description
Study Type
Enrollment (Anticipated)
Phase
- Not Applicable
Contacts and Locations
Study Contact
- Name: Doris Sau Fung YU, PhD
- Phone Number: 39176319
- Email: dyu1@hku.hk
Study Locations
-
-
-
Hong Kong, Hong Kong
- Recruiting
- Department of Medicine, Tseung Kwan O Hospital
-
Contact:
- YU Doris Sau Fung, PhD
- Phone Number: 39176319
- Email: dyu1@hku.hk
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Description
Inclusion Criteria:
- Aged 55 or over
- Confirmed medical diagnosis of Heart Failure by a cardiologist of at least 6 months
- New York Heart Association (NYHA) Class II-IV symptoms
- Discharged home after an admission to the recruitment setting
- Carer co-residing with the patients in the same household
- Carer self-identified as the primary carer for the patients
- Both the patient and the carer having adequate cognitive ability (as indicated by an Abbreviated Test Score of >6)
- Have at least one Smartphone or device to access the online meetings and videos
Exclusion Criteria:
- Not living with primary caregiver
- With end-stage renal disease relying on hemodialysis rather than HF medications to regulate fluid volume.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Supportive Care
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Double
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Dyadic Empowerment-based Heart Failure program (De-HF)
The 16-week De-HF Program is delivered on a dyadic basis.
The program consists of three core elements: i) joint dyadic interview in a home visit (1st-2nd week), ii) five ICT-enhanced empowerment-based modules (3rd-12th week; 2 sessions/ each module), and iii) post-module telephone follow-up (13th-16th week).
The overall aim of the dyadic interview is to understand their usual pattern of collaboration, deficits, strengths and competing concerns in disease management.
This is followed by the empowerment modules with the purpose to help the care dyads to get a consensus in disease interpretation (1st session: Perceptual and Cognitive Empowerment Session) and develop collaborative goal attainment process (2nd Session: Collaborative Gaol-Setting Process).
This will be followed by two bi-weekly telephone calls to the care dyads using a speaker phone to monitor their level of goal attainment for the five modules, and to give further advice and counselling.
|
The 16-week De-HF Program is delivered on a dyadic basis, The program consists of three core elements: i) joint dyadic interview in a home visit (1st-2nd week), ii) five ICT-enhanced empowerment-based modules (3rd-12th week; 2 sessions/ each module), and iii) post-module telephone follow-up (13th-16th week).
The overall aim of the dyadic interview is to understand their usual pattern of collaboration, deficits, strengths and competing concerns in disease management.
This is followed by the empowerment modules with the purpose to help the care dyads to get a consensus in disease interpretation (1st session: Perceptual and Cognitive Empowerment Session) and develop collaborative goal attainment process (2nd Session: Collaborative Gaol-Setting Process).
This will be followed by two bi-weekly telephone calls to the care dyads using a speaker phone to monitor their level of goal attainment for the five modules, and to give further advice and counselling.
|
Active Comparator: Dyadic education program
The 16-week HF education program comprises a home visit, five bi-weekly online training sessions, and the subsequent telephone follow-up for the care dyads.
The nurse will first assess how they manage HF in terms of medication compliance, fluid and dietary control, symptom monitoring and responses in a home visit and clarify their major misconceptions in self-care.
This will be followed by five bi-weekly online education sessions on the same topics as the empowerment modules in the De-HF program.
|
The 16-week HF education program comprises a home visit, five bi-weekly online training sessions, and the subsequent telephone follow-up for the care dyads.
The nurse will first assess how they manage HF in terms of medication compliance, fluid and dietary control, symptom monitoring and responses in a home visit and clarify their major misconceptions in self-care.
This will be followed by five bi-weekly online education sessions on the same topics as the empowerment modules in the De-HF program.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Self-Care Heart Failure Index (SCHFI, v.7.2)
Time Frame: Baseline
|
Measure the self-care maintenance, self-care management, and symptom perception of the HF patients.
There are 28 questions are rated from 1 to 5, and one question are rated from 0 to 5. The three subscale scores are transformed to 0-100, with higher scores indicating better self-care attributes.
|
Baseline
|
Self-Care Heart Failure Index (SCHFI, v.7.2)
Time Frame: 16th week
|
Measure the self-care maintenance, self-care management, and symptom perception of the HF patients.
There are 28 questions are rated from 1 to 5, and one question are rated from 0 to 5. The three subscale scores are transformed to 0-100, with higher scores indicating better self-care attributes.
|
16th week
|
Self-Care Heart Failure Index (SCHFI, v.7.2)
Time Frame: 24th week
|
Measure the self-care maintenance, self-care management, and symptom perception of the HF patients.
There are 28 questions are rated from 1 to 5, and one question are rated from 0 to 5. The three subscale scores are transformed to 0-100, with higher scores indicating better self-care attributes.
|
24th week
|
Self-Care Heart Failure Index (SCHFI, v.7.2)
Time Frame: 32nd week
|
Measure the self-care maintenance, self-care management, and symptom perception of the HF patients.
There are 28 questions are rated from 1 to 5, and one question are rated from 0 to 5. The three subscale scores are transformed to 0-100, with higher scores indicating better self-care attributes.
|
32nd week
|
Minnesota Living with Heart Failure (MLHF) questionnaire
Time Frame: Baseline
|
Measure the disease-specific HRQL (primary outcome of the HF patient), covering the physical and emotional health of HF patients.
There are 21 items and each item is rated from 0 to 5, with higher scores indicating poor health.
|
Baseline
|
Minnesota Living with Heart Failure (MLHF) questionnaire
Time Frame: 16th week
|
Measure the disease-specific HRQL (primary outcome of the HF patient), covering the physical and emotional health of HF patients.
There are 21 items and each item is rated from 0 to 5, with higher scores indicating poor health.
|
16th week
|
Minnesota Living with Heart Failure (MLHF) questionnaire
Time Frame: 24th week
|
Measure the disease-specific HRQL (primary outcome of the HF patient), covering the physical and emotional health of HF patients.
There are 21 items and each item is rated from 0 to 5, with higher scores indicating poor health.
|
24th week
|
Minnesota Living with Heart Failure (MLHF) questionnaire
Time Frame: 32nd week
|
Measure the disease-specific HRQL (primary outcome of the HF patient), covering the physical and emotional health of HF patients.
There are 21 items and each item is rated from 0 to 5, with higher scores indicating poor health.
|
32nd week
|
The EuroQoL-5D-5L instruments
Time Frame: Baseline
|
Assess the health-related quality of life of the care dyads and to generate the utility score for cost-effective analysis.
It consists of two parts, with the first part to assess the health status on mobility, self-care, usual activities, pain/discomfort, and anxiety/depression using a 5-level (no problems, slight problems, moderate problems, severe problems and unable to) response set, with "unable to" levels mean a worse situation.
The second part as a 0-100 scores VAS to measure perceived health, higher scores mean a better outcome.
|
Baseline
|
The EuroQoL-5D-5L instruments
Time Frame: 16th week
|
Assess the health-related quality of life of the care dyads and to generate the utility score for cost-effective analysis.
It consists of two parts, with the first part to assess the health status on mobility, self-care, usual activities, pain/discomfort, and anxiety/depression using a 5-level (no problems, slight problems, moderate problems, severe problems and unable to) response set, with "unable to" levels mean a worse situation.
The second part as a 0-100 scores VAS to measure perceived health, higher scores mean a better outcome.
|
16th week
|
The EuroQoL-5D-5L instruments
Time Frame: 24th week
|
Assess the health-related quality of life of the care dyads and to generate the utility score for cost-effective analysis.
It consists of two parts, with the first part to assess the health status on mobility, self-care, usual activities, pain/discomfort, and anxiety/depression using a 5-level (no problems, slight problems, moderate problems, severe problems and unable to) response set, with "unable to" levels mean a worse situation.
The second part as a 0-100 scores VAS to measure perceived health, higher scores mean a better outcome.
|
24th week
|
The EuroQoL-5D-5L instruments
Time Frame: 32nd week
|
Assess the health-related quality of life of the care dyads and to generate the utility score for cost-effective analysis.
It consists of two parts, with the first part to assess the health status on mobility, self-care, usual activities, pain/discomfort, and anxiety/depression using a 5-level (no problems, slight problems, moderate problems, severe problems and unable to) response set, with "unable to" levels mean a worse situation.
The second part as a 0-100 scores VAS to measure perceived health, higher scores mean a better outcome.
|
32nd week
|
Shared Care Instrument-Revised (SCI-3)
Time Frame: Baseline
|
Measure the level of shared care in terms of communication, decision-making, and reciprocity of care dyads.
Each item is rated from zero to five (completely agree, mostly agree, slightly agree, slightly disagree, mostly disagree, and completely disagree), with higher scores representing better shared care.
|
Baseline
|
Shared Care Instrument-Revised (SCI-3)
Time Frame: 16th week
|
Measure the level of shared care in terms of communication, decision-making, and reciprocity of care dyads.
Each item is rated from zero to five (completely agree, mostly agree, slightly agree, slightly disagree, mostly disagree, and completely disagree), with higher scores representing better shared care.
|
16th week
|
Shared Care Instrument-Revised (SCI-3)
Time Frame: 24th week
|
Measure the level of shared care in terms of communication, decision-making, and reciprocity of care dyads.
Each item is rated from zero to five (completely agree, mostly agree, slightly agree, slightly disagree, mostly disagree, and completely disagree), with higher scores representing better shared care.
|
24th week
|
Shared Care Instrument-Revised (SCI-3)
Time Frame: 32nd week
|
Measure the level of shared care in terms of communication, decision-making, and reciprocity of care dyads.
Each item is rated from zero to five (completely agree, mostly agree, slightly agree, slightly disagree, mostly disagree, and completely disagree), with higher scores representing better shared care.
|
32nd week
|
Control Attitude Scale Revised (CAS-R)
Time Frame: Baseline
|
Measure the perceived control in disease management.
Each item was rated on a 5-point Likert scale from 1 (strongly disagree) to 5 (strongly agree) and summed to create a total score after two negative items were reverse coded.
The possible total score ranges from 8 to 40 with a higher score indicating higher perceived controllability.
|
Baseline
|
Control Attitude Scale Revised (CAS-R)
Time Frame: 16th week
|
Measure the perceived control in disease management.
Each item was rated on a 5-point Likert scale from 1 (strongly disagree) to 5 (strongly agree) and summed to create a total score after two negative items were reverse coded.
The possible total score ranges from 8 to 40 with a higher score indicating higher perceived controllability.
|
16th week
|
Control Attitude Scale Revised (CAS-R)
Time Frame: 24th week
|
Measure the perceived control in disease management.
Each item was rated on a 5-point Likert scale from 1 (strongly disagree) to 5 (strongly agree) and summed to create a total score after two negative items were reverse coded.
The possible total score ranges from 8 to 40 with a higher score indicating higher perceived controllability.
|
24th week
|
Control Attitude Scale Revised (CAS-R)
Time Frame: 32nd week
|
Measure the perceived control in disease management.
Each item was rated on a 5-point Likert scale from 1 (strongly disagree) to 5 (strongly agree) and summed to create a total score after two negative items were reverse coded.
The possible total score ranges from 8 to 40 with a higher score indicating higher perceived controllability.
|
32nd week
|
Collaborators and Investigators
Sponsor
Collaborators
Investigators
- Principal Investigator: Doris Sau Fung YU, PhD, The University of Hong Kong
Publications and helpful links
General Publications
- Vellone E, Rebora P, Ausili D, Zeffiro V, Pucciarelli G, Caggianelli G, Masci S, Alvaro R, Riegel B. Motivational interviewing to improve self-care in heart failure patients (MOTIVATE-HF): a randomized controlled trial. ESC Heart Fail. 2020 Jun;7(3):1309-1318. doi: 10.1002/ehf2.12733. Epub 2020 Apr 28.
- Jaarsma T, Hill L, Bayes-Genis A, La Rocca HB, Castiello T, Celutkiene J, Marques-Sule E, Plymen CM, Piper SE, Riegel B, Rutten FH, Ben Gal T, Bauersachs J, Coats AJS, Chioncel O, Lopatin Y, Lund LH, Lainscak M, Moura B, Mullens W, Piepoli MF, Rosano G, Seferovic P, Stromberg A. Self-care of heart failure patients: practical management recommendations from the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail. 2021 Jan;23(1):157-174. doi: 10.1002/ejhf.2008. Epub 2020 Oct 20.
- Yu DS, Lee DT, Stewart S, Thompson DR, Choi KC, Yu CM. Effect of Nurse-Implemented Transitional Care for Chinese Individuals with Chronic Heart Failure in Hong Kong: A Randomized Controlled Trial. J Am Geriatr Soc. 2015 Aug;63(8):1583-93. doi: 10.1111/jgs.13533.
- Riegel B, Barbaranelli C, Carlson B, Sethares KA, Daus M, Moser DK, Miller J, Osokpo OH, Lee S, Brown S, Vellone E. Psychometric Testing of the Revised Self-Care of Heart Failure Index. J Cardiovasc Nurs. 2019 Mar/Apr;34(2):183-192. doi: 10.1097/JCN.0000000000000543.
- Ho CC, Clochesy JM, Madigan E, Liu CC. Psychometric evaluation of the Chinese version of the Minnesota Living with Heart Failure Questionnaire. Nurs Res. 2007 Nov-Dec;56(6):441-8. doi: 10.1097/01.NNR.0000299849.21935.c4.
- Chen S, Zheng S, Wang X, Zhang X, Fa T, Fu L, Zang X, Zhao Y. Linguistic and Psychometric Validation of the Chinese Version of the Control Attitudes Scale-Revised in Patients With Chronic Heart Failure. J Cardiovasc Nurs. 2021 Jul-Aug 01;36(4):349-356. doi: 10.1097/JCN.0000000000000705.
- Groenewegen A, Rutten FH, Mosterd A, Hoes AW. Epidemiology of heart failure. Eur J Heart Fail. 2020 Aug;22(8):1342-1356. doi: 10.1002/ejhf.1858. Epub 2020 Jun 1.
- Ryan CJ, Bierle RS, Vuckovic KM. The Three Rs for Preventing Heart Failure Readmission: Review, Reassess, and Reeducate. Crit Care Nurse. 2019 Apr;39(2):85-93. doi: 10.4037/ccn2019345. Erratum In: Crit Care Nurse. 2019 Oct;39(5):12.
- Jonkman NH, Westland H, Groenwold RH, Agren S, Atienza F, Blue L, Bruggink-Andre de la Porte PW, DeWalt DA, Hebert PL, Heisler M, Jaarsma T, Kempen GI, Leventhal ME, Lok DJ, Martensson J, Muniz J, Otsu H, Peters-Klimm F, Rich MW, Riegel B, Stromberg A, Tsuyuki RT, van Veldhuisen DJ, Trappenburg JC, Schuurmans MJ, Hoes AW. Do Self-Management Interventions Work in Patients With Heart Failure? An Individual Patient Data Meta-Analysis. Circulation. 2016 Mar 22;133(12):1189-98. doi: 10.1161/CIRCULATIONAHA.115.018006. Epub 2016 Feb 12.
- Buck HG, Harkness K, Wion R, Carroll SL, Cosman T, Kaasalainen S, Kryworuchko J, McGillion M, O'Keefe-McCarthy S, Sherifali D, Strachan PH, Arthur HM. Caregivers' contributions to heart failure self-care: a systematic review. Eur J Cardiovasc Nurs. 2015 Feb;14(1):79-89. doi: 10.1177/1474515113518434. Epub 2014 Jan 6.
- Strachan PH, Currie K, Harkness K, Spaling M, Clark AM. Context matters in heart failure self-care: a qualitative systematic review. J Card Fail. 2014 Jun;20(6):448-55. doi: 10.1016/j.cardfail.2014.03.010. Epub 2014 Apr 13.
- Clark AM, Spaling M, Harkness K, Spiers J, Strachan PH, Thompson DR, Currie K. Determinants of effective heart failure self-care: a systematic review of patients' and caregivers' perceptions. Heart. 2014 May;100(9):716-21. doi: 10.1136/heartjnl-2013-304852. Epub 2014 Feb 18.
- Buck HG, Stromberg A, Chung ML, Donovan KA, Harkness K, Howard AM, Kato N, Polo R, Evangelista LS. A systematic review of heart failure dyadic self-care interventions focusing on intervention components, contexts, and outcomes. Int J Nurs Stud. 2018 Jan;77:232-242. doi: 10.1016/j.ijnurstu.2017.10.007. Epub 2017 Oct 19.
- Lyons KS, Lee CS. The Theory of Dyadic Illness Management. J Fam Nurs. 2018 Feb;24(1):8-28. doi: 10.1177/1074840717745669. Epub 2018 Jan 20.
- Sebern M, Riegel B. Contributions of supportive relationships to heart failure self-care. Eur J Cardiovasc Nurs. 2009 Jun;8(2):97-104. doi: 10.1016/j.ejcnurse.2008.07.004. Epub 2008 Aug 15.
- Srisuk N, Cameron J, Ski CF, Thompson DR. Randomized controlled trial of family-based education for patients with heart failure and their carers. J Adv Nurs. 2017 Apr;73(4):857-870. doi: 10.1111/jan.13192. Epub 2016 Nov 30.
- Sebern MD, Woda A. Shared care dyadic intervention: outcome patterns for heart failure care partners. West J Nurs Res. 2012 Apr;34(3):289-316. doi: 10.1177/0193945911399088. Epub 2011 Mar 7.
- Boczor S, Daubmann A, Eisele M, Blozik E, Scherer M. Quality of life assessment in patients with heart failure: validity of the German version of the generic EQ-5D-5L. BMC Public Health. 2019 Nov 6;19(1):1464. doi: 10.1186/s12889-019-7623-2.
- Tidermark J, Bergstrom G, Svensson O, Tornkvist H, Ponzer S. Responsiveness of the EuroQol (EQ 5-D) and the SF-36 in elderly patients with displaced femoral neck fractures. Qual Life Res. 2003 Dec;12(8):1069-79. doi: 10.1023/a:1026193812514.
- Yu DS, Li PW, Zhang F, Cheng ST, Ng TK, Judge KS. The effects of a dyadic strength-based empowerment program on the health outcomes of people with mild cognitive impairment and their family caregivers: a randomized controlled trial. Clin Interv Aging. 2019 Oct 4;14:1705-1717. doi: 10.2147/CIA.S213006. eCollection 2019.
- Rahmani A, Vahedian-Azimi A, Sirati-Nir M, Norouzadeh R, Rozdar H, Sahebkar A. The Effect of the Teach-Back Method on Knowledge, Performance, Readmission, and Quality of Life in Heart Failure Patients. Cardiol Res Pract. 2020 Nov 23;2020:8897881. doi: 10.1155/2020/8897881. eCollection 2020.
- Wong EL, Cheung AW, Wong AY, Xu RH, Ramos-Goni JM, Rivero-Arias O. Normative Profile of Health-Related Quality of Life for Hong Kong General Population Using Preference-Based Instrument EQ-5D-5L. Value Health. 2019 Aug;22(8):916-924. doi: 10.1016/j.jval.2019.02.014. Epub 2019 Jul 27.
- Sebern MD. Refinement of the Shared Care Instrument-Revised: a measure of a family care interaction. J Nurs Meas. 2008;16(1):43-60. doi: 10.1891/1061-3749.16.1.43.
- Vickerstaff V, Ambler G, King M, Nazareth I, Omar RZ. Are multiple primary outcomes analysed appropriately in randomised controlled trials? A review. Contemp Clin Trials. 2015 Nov;45(Pt A):8-12. doi: 10.1016/j.cct.2015.07.016. Epub 2015 Jul 26.
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- DE-HF
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
IPD Plan Description
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Heart Failure
-
Tufts Medical CenterMetro West Medical CenterCompletedCongestive Heart Failure | Diastolic Heart Failure | Systolic Heart FailureUnited States
-
Abbott Medical DevicesCompletedHeart Failure | Heart Failure, Diastolic | Heart Failure, Systolic | Heart Failure NYHA Class II | Heart Failure NYHA Class III | Heart Failure With Reduced Ejection Fraction | Heart Failure NYHA Class IV | Heart Failure With Normal Ejection Fraction | Heart Failure; With Decompensation | Heart Failure...United States, Canada
-
Manipal UniversityUnknownHeart Failure | Decompensated Heart Failure | Acute Heart Failure | Diastolic Heart Failure | Systolic Heart FailureIndia
-
VA Eastern Colorado Health Care SystemNational Institute on Aging (NIA)CompletedHeart Failure | Heart Failure, Diastolic | Heart Failure, Systolic | Heart Failure With Reduced Ejection Fraction | Heart Failure With Preserved Ejection Fraction | Heart Failure; With Decompensation | Heart Failure,Congestive | Heart Failure AcuteUnited States
-
University Hospital, MontpellierCompletedHeart Failure | Diastolic Heart Failure | Systolic Heart Failure Stage CFrance
-
Wake Forest UniversityCompletedHeart Failure, Congestive | Heart Failure With Preserved Ejection Fraction
-
Wake Forest UniversityNational Institute on Aging (NIA)CompletedHeart Failure, Congestive | Diastolic Heart FailureUnited States
-
Lancaster General HospitalLouise von Hess Medical Research InstituteEnrolling by invitationDiastolic Heart FailureUnited States
-
Giresun UniversityIstanbul University - Cerrahpasa (IUC)RecruitingHeart Failure | Diastolic Heart Failure | Systolic Heart FailureTurkey
-
University of British ColumbiaCanadian Institutes of Health Research (CIHR); Duke University; St. Paul's Hospital... and other collaboratorsActive, not recruitingHeart Diseases | Heart Failure | Transplant; Failure, Heart | Heart Transplant Failure and Rejection | Heart Failure,Congestive | Transplant FailureCanada, United States
Clinical Trials on Dyadic empowerment based heart failure management program
-
University of Colorado, DenverNational Heart, Lung, and Blood Institute (NHLBI)CompletedCongestive Heart Failure | Cardiac FailureUnited States
-
The University of Hong KongChinese University of Hong Kong; Novartis Pharmaceuticals; Biofourmis Singapore...Active, not recruitingHeart Failure With Reduced Ejection FractionHong Kong
-
University College, LondonBritish Society for Heart Failure; National Institute for Cardiovascular Outcomes...UnknownHeart FailureUnited Kingdom
-
Jana CareMassachusetts General HospitalCompletedHeart FailureUnited States
-
The Hong Kong Polytechnic UniversityUnknownChronic PainHong Kong
-
American Heart AssociationRecruiting
-
Radboud University Medical CenterCompleted
-
Hong Kong Metropolitan UniversityThe University of Hong Kong; The Hong Kong Polytechnic University; Health and... and other collaboratorsRecruitingChronic Pain | Elderly | Informal Caregivers | Dyadic InterventionHong Kong
-
University of LeedsNational Institute for Health Research, United KingdomUnknownCongestive Heart Failure | Pacemaker ComplicationUnited Kingdom
-
Cambridge Cardiac Care CentreRecruitingHeart Failure With Reduced Ejection FractionCanada