The South Texas Aging Registry and Repository (STARR)

The South Texas Aging Registry and Repository (STARR)

This research registry and repository was designed because the investigators want to learn about how to improve the health and quality of life of older adults.

Study Overview

• Status: Recruiting
• Conditions: Aging

Detailed Description

The South Texas Aging Registry and Repository (STARR) is a database and specimen resource of community dwelling adults from the South Texas area who are interested in volunteering for research studies on aging. The goal is to assist in the inclusion of older adults in clinical research studies and to help to increase the quantity and quality of research relating to them. This registry and repository can be used for various purposes ranging from describing the natural history of aging, identifying risk factors for premature aging, and the real-world effectiveness of life-extending therapies. Collection and storage of biological samples and patient-reported data from of Individuals can help advance research and the development of new awareness of basic mechanisms that play a part in healthy aging or premature death.

• Study Type: Observational
• Enrollment (Anticipated): 999

Contacts and Locations

• Study Contact: Name: Sara Espinoza, MD; Phone Number: (210) 617-5197; Email: espinozas2@uthscsa.edu
• Study Contact Backup: Name: Nicolas Musi, MD; Phone Number: (210) 562-6140; Email: Musi@uthscsa.edu

Study Locations

• United States
  • Texas
    • San Antonio, Texas, United States, 78229
      • Recruiting
      • The University of Texas Health Science Center at San Antonio

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: Yes

• Sampling Method: Non-Probability Sample

Study Population

Community dwelling adults from the South Texas area who are interested in volunteering for research studies on aging.

Description

Inclusion Criteria STARR:

-Age 18 years or older

Inclusion Criteria KAPP Sen TMC:

-Age 20 years and older

Exclusion Criteria STARR:

• Inability to provide informed consent
• Pregnancy

Exclusion Criteria KAPP Sen Tissue Mapping Center (TMC) Study:

• Diabetes
• Hypertension with end-organ damage
• BMI>30
• GFR<60 ml/min/1.73 m2
• Cardiovascular disease
• Pancreatitis
• Malignancy other than non-melanoma skin cancers
• Active, uncontrolled pulmonary, hepatic, infectious, gastrointestinal, endocrine, neurologic, or inflammatory disease.
• Chronic use of systemic steroids or use of agents with senolytic activity
• Any disease or condition considered to be exclusionary based on the clinical option and discretion of PI

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort
Primary Study; Community dwelling adults from the South Texas area who are interested in volunteering for research studies on aging. This will facilitate the inclusion of older adults and minority in research studies and help to increase the quantity and quality of research relating to them.
KAPP Sen Tissue Mapping Study; The substudy KAPP Sen TMC will enroll eligible STARR participants to undergo repeat assessments over two years. KAPP Sen TMC is a collaborative effort between UT Health San Antonio, Jackson Laboratory for Genomic Medicine (JAX-GM), Brigham and Women's Hospital, Joslin Diabetes Center, UConn Health Center on Aging and Mayo Clinic to characterize cellular senescence in terms of its presence and heterogeneity in healthy human tissues, as well as its tissue burden, spatial distribution, and biological features in a diverse study population.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Collection of STARR repository data	De-identified repository data and samples will be made available to outside investigators for future studies related to aging	Baseline to one day

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
KAPP Sen TMC repository data	Eligible STARR participants to undergo repeat assessments to characterize cellular senescence	Baseline to one year

Collaborators and Investigators

• Sponsor: The University of Texas Health Science Center at San Antonio
• Investigators: Principal Investigator: Sara Espinoza, MD, University of Texas Health Science Center San Antonio

Study record dates

Study Major Dates

• Study Start (Actual): February 11, 2019
• Primary Completion (Anticipated): December 1, 2029
• Study Completion (Anticipated): December 1, 2030

Study Registration Dates

• First Submitted: April 18, 2023
• First Submitted That Met QC Criteria: April 18, 2023
• First Posted (Actual): April 28, 2023

Study Record Updates

• Last Update Posted (Actual): April 28, 2023
• Last Update Submitted That Met QC Criteria: April 18, 2023
• Last Verified: April 1, 2023

More Information

Terms related to this study

• Keywords: Older adults; Biorepository; Genetic material
• Other Study ID Numbers: HSC20150610H

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: YES

IPD Plan Description

New prospective studies and those involving interacting with human subjects: Participants/research volunteers who agree to be re-contacted will be matched with future studies which they are likely to qualify for based upon information provided by each STARR participant at the time of enrollment and which is gathered using provided samples.

KAPP Sen TMC will support the use of a web-based platform to connect and facilitate entering, sharing, and exchanging data among collaborates. Data will be exported to a web portal developed in conjunction with the CODCC where the research community can request access to molecular data and corresponding biospecimen data, such as clinical, demographic, and biospecimen handling data.

• IPD Sharing Time Frame: Requests from investigators to obtain data/specimens from the repository must be submitted in writing using an official repository request form, along with study protocol and documentation of appropriate approvals. Requests will be reviewed on a monthly basis by members of the Repository Executive Committee. Request to access data or specimens will be processed and entered into the Repository Log by the Repository Coordinator and submitted for review by the Executive Committee each month.
• IPD Sharing Supporting Information Type: STUDY_PROTOCOL; SAP

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No