Resistance Training With Blood Flow Restriction

Resistance Training With Blood Flow Restriction for the Lower Extremity Muscles

Blood flow restriction associated with resistance training is suggested to potentiate increases in muscular strength and hypertrophy. This study will compare the effects of resistance training associated with blood flow restriction with a regular resistance training program. Findings of this project will provide important information regarding a promising intervention to potentiate muscle performance.

Study Overview

• Status: Recruiting
• Conditions: Healthy
• Intervention / Treatment: Other: Blood flow restriction; Other: Regular training type 1; Other: Regular training type 2

Detailed Description

The purpose of this study is to determine alterations in motor unit behavior of the tibialis anterior muscles after a resistance exercise program associated with blood flow restriction. Our working hypothesis is that blood flow restriction to working muscles will induce greater changes in muscle activation, lean mass and muscle size compared with a training at same intensity without blood flow restriction.

• Study Type: Interventional
• Enrollment (Estimated): 60
• Phase: Not Applicable

Contacts and Locations

• Study Contact: Name: Hugo Pereira, PhD; Phone Number: 4053252773; Email: hugomax@ou.edu

Study Locations

• United States
  • Oklahoma
    • Norman, Oklahoma, United States, 73071
      • Recruiting
      • University of Oklahoma
      • Contact: Hugo Pereira, PhD; Phone Number: 405-325-2773; Email: hugomax@ou.edu

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult
• Accepts Healthy Volunteers: Yes

Description

Exclusion Criteria:

• presence of neurological diseases,
• presence of metal implants or joint replacement
• any restriction to perform physical activity
• pregnancy

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: None (Open Label)

Number of Arms

3

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Group 1; Strength training associated with blood flow restriction	Other: Blood flow restriction; Strength training of the lower leg muscles using blood flow restriction
Experimental: Group 2; Conventional strength training using high loads	Other: Regular training type 1; Strength training of the lower leg muscles using high loads
Experimental: Group 3; Conventional strength training using low loads	Other: Regular training type 2; Strength training of the lower leg muscles using low loads

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Force	Force of the lower leg muscles using a custom made ergometer	10 sessions (up to 6 weeks)

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Body composition	dual x-ray absorptiometry (DEXA) will be used to assess body composition	Start and end of the protocol

Collaborators and Investigators

• Sponsor: University of Oklahoma
• Investigators: Principal Investigator: Hugo Pereira, PhD, University of Oklahoma

Study record dates

Study Major Dates

• Study Start (Actual): November 1, 2022
• Primary Completion (Estimated): May 31, 2025
• Study Completion (Estimated): September 30, 2026

Study Registration Dates

• First Submitted: April 17, 2023
• First Submitted That Met QC Criteria: May 8, 2023
• First Posted (Actual): May 17, 2023

Study Record Updates

• Last Update Posted (Estimated): December 7, 2023
• Last Update Submitted That Met QC Criteria: November 30, 2023
• Last Verified: November 1, 2023

More Information

Terms related to this study

• Keywords: strength training; body composition; resistance training; blood flow restriction; motor units
• Other Study ID Numbers: 14083

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: YES
• IPD Plan Description: deidentified information can be shared according to instructions of the local institutional review board that reviewed the study
• IPD Sharing Supporting Information Type: STUDY_PROTOCOL

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No