- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05881460
Vibrotactile Coordinated Reset: A Non-invasive Treatment for Parkinson's Disease 2
Vibrotactile Coordinated Reset: A Non-invasive Treatment for Parkinson's Disease
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
This vCR study will include a crossover design, where participants are their own control and receive both active stimulation and sham, aiding in understanding true treatment effects from vCR.
Current treatments for PD include medications, surgical measures, or a combination of both. However, long term use of medications can result in intolerable side effects, especially at higher doses. Although DBS is FDA approved and an established method to manage symptoms of PD, it is an invasive and expensive procedure and may not improve all symptoms of PD. The team at Synergic Medical Technologies, Inc. developed a non-invasive method of applying vibrotactile stimulation delivered through the fingertips that has the potential of theoretically disrupting abnormal synchrony in the brain and thus alleviate severity in motor symptoms in people with PD.
The purpose of this study is to test the use of vibrotactile stimulation on 30 participants with PD and vCRs effects on motor ability using the VT Touch.
Study Type
Enrollment (Estimated)
Phase
- Not Applicable
Contacts and Locations
Study Contact
- Name: Jeff Kraakevik, MD
- Phone Number: 503-494-8311
- Email: kraakevi@ohsu.edu
Study Locations
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Oregon
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Portland, Oregon, United States, 97239
- Recruiting
- Oregon Health & Science Institution
-
Contact:
- Jeff Kraakevik, MD
- Phone Number: 503-494-8311
- Email: kraakevi@ohsu.edu
-
Contact:
- Jacquie Ellison
- Phone Number: 503-418-2602
- Email: ellisoia@ohsu.edu
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Adult
- Older Adult
Accepts Healthy Volunteers
Description
Inclusion Criteria:
- Between the ages of 45-85
- Diagnosis of idiopathic Parkinson's disease from movement disorders neurologist with the United Kingdom Brain Bank criteria of bradykinesia and one or more of the following: rest tremor, rigidity, and balance problems not from visual, vestibular, cerebellar, or proprioceptive conditions
- Bilateral, moderate-stage impairment, as defined as Hoehn & Yahr Stages II-IV in the on-medication state
- Able to walk and stand unassisted
- Participants must be on a stable regimen of PD medication (at least 4 weeks prior to enrollment)
- Responsive to levodopa (self-reported)
- Willing to keep exercise and medication regimen as stable as possible for the duration of the study
- Able to provide informed consent
- Independently, or with social support, able to use technology and access virtual meeting if needed to troubleshoot technology
- Participants must speak English and can communicate with staff
- Patients live close to or in the area of where the clinic is located and are able to travel to the clinic for all screening and assessment appointments.
Exclusion Criteria:
Severe depression or suicide ideation (as assessed with Beck Depression Inventory (BDI), BDI <28, and Columbia Suicide Severity Rating scale (SSRS), C-SSRS < 4)
*BDI score > 28, indicating severe depression that precludes ability to adhere to protocol. Any subject with such a score will be referred to a Primary Care Physician (PCP) or physician for further evaluation and management of depression. Individuals with a BDI score of 17-28 will be excluded if any of the following conditions are met: (1) individual is suicidal, (2) is in need of depression treatment modification currently or (3) depressive symptoms likely to interfere with adherence to study protocol. Any subject with such a score will be referred to a PCP or physician for further evaluation and management of depression.
- Presence of other neurological or musculoskeletal disorders as determined by the physician during screening.
- Participation in another drug, device, biologic, or intervention trial concurrently or within the preceding 2-month
- Physical limitations unrelated to Parkinson's disease
- Recent change or addition of psychoactive medications for non-parkinsonian treatments
- Any kind of brain surgery or neurostimulators
- Pregnancy, breastfeeding, or lack of reliable contraception in women of childbearing age
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Crossover Assignment
- Masking: Quadruple
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Active Comparator: Active vibrotactile coordinated reset
Participants will receive active Vibrotactile Coordinated Reset stimulation.
|
Vibrotactile Coordinated Reset delivers vibratory stimulation to the fingertips of each hand.
A specific pattern of vibration to each fingertip is delivered which theoretically disrupts abnormal synchrony in the brain.
Other Names:
|
Sham Comparator: Sham vibrotactile coordinated reset
Participants will receive inactive Vibrotactile Coordinated Reset stimulation.
|
Vibrotactile Coordinated Reset delivers vibratory stimulation to the fingertips of each hand.
An inactive pattern of vibration to each fingertip is delivered which theoretically will not have the effects of active vCR.
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Change in Movement Disorders Society's Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Part 3
Time Frame: baseline, 4 months, 5 months, 9 months
|
Difference in MDS-UPDRS Part 3 from baseline to 4 months between active and sham.
Range is 0-72 (18 items with 4 being max for each item), higher being worse
|
baseline, 4 months, 5 months, 9 months
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Change in gait speed as measured by Ambulatory Parkinson's Disease Monitoring (APDM) Mobility Lab
Time Frame: baseline, 4 months, 5 months, 9 months
|
Difference in APDM gait speed from baseline to 4 months between active and sham
|
baseline, 4 months, 5 months, 9 months
|
Quality of life improvements
Time Frame: baseline, 4 months, 5 months, 9 months
|
Quality of life improvements as measured by the Parkinson's disease Quality of Life questionnaire (PDQ-39)
|
baseline, 4 months, 5 months, 9 months
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Change in freezing severity index
Time Frame: baseline, 4 months, 5 months, 9 months
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Change in freezing severity index quantified during a turning in place task and other gait spatio-temporal parameters
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baseline, 4 months, 5 months, 9 months
|
Collaborators and Investigators
Investigators
- Principal Investigator: Jeff Kraakivk, MD, Oregon Health and Science University
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 25412
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
product manufactured in and exported from the U.S.
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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