- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT06272201
Incisionless Suture Plications in a POSE2.0 Interventional Randomized Obesity Study (INSPIRO)
February 14, 2024 updated by: USGI Medical
Incisionless Suture Plications in a POSE2.0 Interventional Randomized Obesity Study (The INSPIRO Study)
This is a multi-center, open-label, 2-group randomized pivotal study evaluating a minimally invasive weight loss procedure.
The intent is to evaluate the safety and effectiveness of POSE2.0 (sutures placed in the mid + distal body without placement in the fundus), with a moderate intensity diet and exercise program, as compared to diet and exercise alone.
The procedure will be performed using the g-Cath EZ Delivery Catheter with Snowshoe Suture Anchors (AKA g-Cath or g-Cath EZ) and associated devices (g-Prox EZ, g-Lix and Transport), known collectively as the Incisionless Operating Platform (IOP).
Study Overview
Status
Not yet recruiting
Conditions
Intervention / Treatment
Detailed Description
This is a multi-center, open-label, 2-group randomized pivotal study evaluating a minimally invasive weight loss procedure.
The intent is to evaluate the safety and effectiveness of POSE2.0 (g-Cath EZ Snowshoe Suture Anchors placed in the mid + distal body without placement in the fundus), with a moderate intensity diet and exercise program, as compared to diet and exercise alone.
The procedure will be performed using the g-Cath EZ Delivery Catheter with Snowshoe Suture Anchors (AKA g-Cath or g-Cath EZ) and associated devices (g-Prox EZ, g-Lix and Transport), known collectively as the Incisionless Operating Platform (IOP).
Study Type
Interventional
Enrollment (Estimated)
186
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Contact
- Name: VP of Medical Affairs
- Phone Number: 949-369-3890
- Email: info@usgimedical.com
Study Contact Backup
- Name: Director, RA/QA
- Phone Number: 949-369-3890
- Email: tpalmer@usgimedical.com
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
- Adult
- Older Adult
Accepts Healthy Volunteers
No
Description
Inclusion Criteria:
- Provision of signed and dated informed consent form.
- Subject agrees to be compliant with study requirements and adhere to post-operative dietary & exercise recommendations for the duration of the study.
- Subjects between the ages of 22-65 years.
- History or failure with non-surgical weight-loss methods.
- If female, be either post-menopausal, surgically sterile, or agree to practice birth control during year of study and have negative serum HCG at screening/baseline.
- Have a Body Mass Index (BMI) of ≥ 30 and ≤ 50 kg/m².
- Absence of current severe systemic disease (including, but not limited to: coronary artery disease, chronic obstructive pulmonary disease, congestive heart failure, cancer, and chronic renal disease).
- Agrees to forego any additional weight loss interventional procedures or liposuction for 12 months following study enrollment.
- Have not taken any prescription or over-the-counter weight loss medications in the last 6 months, with exception of medications used to manage T2D so long as the subject has been on a stable dose and weight has persisted.
- Residing within a reasonable distance from the Investigator's treating office (~50 miles) and willing and able to travel to the Investigator's office to complete all routine follow-up visits.
Exclusion Criteria:
- History of or intra-operative evidence of prior bariatric, gastric or esophageal surgery.
- Esophageal stricture or other anatomy and/or condition that could preclude passage of endoluminal instruments or procedure execution.
- Moderate gastro-esophageal reflux disease (GERD), defined as symptoms that cause subject severe discomfort, compromise performance of daily activities, and/or condition is not entirely controlled with drug therapy.
- Large hiatal hernia (>3 cm) by history or as determined by pre-enrollment endoscopy.
- Pancreatic insufficiency/disease.
- History of gastroparesis or symptoms that would be suggestive of gastroparesis or generalized dysmotility (e.g., esophago-gastric motility issues and lower esophageal sphincter abnormalities).
- Patients who are known to be pregnant or breast-feeding, or plan to become pregnant in the next 12 months.
- History of a known diagnosis or pre-existing symptom of rheumatoid arthritis, scleroderma, system lupus, or other autoimmune connective tissue disorder.
- Immunosuppressive medications or systemic steroids (i.e., oral prednisone) within 6 months of Visit 1. Intranasal/inhaled steroids are acceptable.
- Unable or unwilling to avoid use of aspirin and/or non-steroidal anti-inflammatory drugs (NSAIDs), or other medications known to be gastric irritants beginning two weeks prior to enrollment and throughout the entire study.
- History of inflammatory disease of the GI tract; coagulation disorders; hepatic insufficiency or cirrhosis.
- Active gastric erosion, lesion, or gastric/duodenal ulcer.
- History of or current platelet or coagulation dysfunction, such as hemophilia.
- History or present use of insulin or insulin derivatives for treatment of diabetes.
- Patients with type II diabetes mellitus on oral agents (not injectables) with HgA1c > 9 at the time of enrollment.
- Active smoker or someone who has been a smoker in the 6 months leading up to the study.
- Portal hypertension and/or varices.
- Patient has a history of drug or alcohol abuse or positive at screening for drug use.
- Patient is currently using marijuana/cannabis for either medicinal or recreational use, or has plans to start using over the next 12 months.
- Present or history of psychosis, bipolar disease, obsessive-compulsive disorder, binge eating, and/or other eating disorders after pre-enrollment history and medical /psychological assessment.
- Beck Depression Inventory (Short) Score ≥ 12, and/or uncontrolled depression after pre-enrollment psychological and medical assessment.
- Patient score >2 in any of the identified symptoms in the nausea/vomiting or bloating/distension domains on the Gastroparesis Cardinal Symptom Index (GCSI).
- Non-ambulatory or has significant impairment of mobility (i.e. cannot ambulate for 30 minutes).
- Known hormonal or genetic cause for obesity including untreated hypothyroidism (TSH >5.0 U/ml).
- Present or history of chronic abdominal pain.
- Participating in another clinical study that could compromise compliance with the POSE2.0 study (must be cleared with investigator and USGI Medical).
- Subjects with a personal history of allergic/anaphylactic reactions including hypersensitivity to the drugs or materials that will be utilized in the study procedure.
- Any other medical condition that would not permit elective endoscopy such as poor general health or history and/or symptoms of severe renal, hepatic, cardiac, and/or pulmonary disease, and/or physician's assessment that the subject is not an appropriate candidate.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Treatment
POSE2.0 Treatment with Lifestyle Modification
|
POSE2.0 (g-Cath EZ snowshoe suture anchors placed in the mid + distal body without placement in the fundus), with a moderate intensity diet and exercise program
|
No Intervention: Control
Lifestyle Modification alone
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Percentage of total body weight loss (%TBWL) following randomization
Time Frame: 12 months
|
To be deemed effective, the difference in %TBWL between the treatment group minus the control group must be significantly greater than 5%.
|
12 months
|
Responder rate of at least 50% in the POSE2.0 treatment group
Time Frame: 12 months
|
Responder defined as >5% TBWL
|
12 months
|
Safety- Incidence of device and procedure related adverse events through 12 months
Time Frame: 12 months
|
Incidence of device and procedure related adverse events through 12 months defined as Clavien-Dindo Class III or greater.
|
12 months
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Principal Investigator: Barham Abu Dayyeh, MD, MPH, Mayo Clinic
- Principal Investigator: Erik Wilson, MD, University of Texas Medical School at Houston
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Estimated)
November 1, 2024
Primary Completion (Estimated)
August 1, 2026
Study Completion (Estimated)
August 1, 2026
Study Registration Dates
First Submitted
February 14, 2024
First Submitted That Met QC Criteria
February 14, 2024
First Posted (Actual)
February 22, 2024
Study Record Updates
Last Update Posted (Actual)
February 22, 2024
Last Update Submitted That Met QC Criteria
February 14, 2024
Last Verified
February 1, 2024
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 50620 TPR
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
NO
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
Yes
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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